A composite score based on immune-related gene prognostic index and m6A risk score of head and neck squamous cell carcinoma
Background: Immunotherapy has been demonstrated favorable in head and neck squamous cell carcinoma (HNSCC). Studies indicated that immune-related gene prognostic index (IRGPI) was a robust signature, and N6-methyladenosine (m6A) methylation had a significant impact on the tumor immune microenvironme...
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| Format: | Article |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2023.1061569/full |
| _version_ | 1811168233993011200 |
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| author | Yizhou Yang Yizhou Yang Yizhou Yang Zeman Cai Kaichun Huang Mei Li Xiao Wang Xiao Wang Xiao Wang Yinbing Lin Yinbing Lin Yinbing Lin Sijie Chen Sijie Chen Sijie Chen Zhining Yang Zhining Yang Zhixiong Lin Zhixiong Lin Zhixiong Lin |
| author_facet | Yizhou Yang Yizhou Yang Yizhou Yang Zeman Cai Kaichun Huang Mei Li Xiao Wang Xiao Wang Xiao Wang Yinbing Lin Yinbing Lin Yinbing Lin Sijie Chen Sijie Chen Sijie Chen Zhining Yang Zhining Yang Zhixiong Lin Zhixiong Lin Zhixiong Lin |
| author_sort | Yizhou Yang |
| collection | DOAJ |
| description | Background: Immunotherapy has been demonstrated favorable in head and neck squamous cell carcinoma (HNSCC). Studies indicated that immune-related gene prognostic index (IRGPI) was a robust signature, and N6-methyladenosine (m6A) methylation had a significant impact on the tumor immune microenvironment (TIME) and immunotherapy of head and neck squamous cell carcinoma. Thus, combining indicated that immune-related gene prognostic index with m6A status should offer a better predictive power for immune responses.Methods: Head and neck squamous cell carcinoma samples from the cancer genome atlas (TCGA, n = 498) and gene expression omnibus database (GSE65858, n = 270) were used in this study. Cox regression analysis was used to construct the indicated that immune-related gene prognostic index through immune-related hub genes which were identified by weighted gene co-expression network analysis (WGCNA). The m6A risk score was constructed by least absolute shrinkage and selection operator (LASSO) regression analysis. Principal component analysis was used to construct a composite score, and systematically correlate subgroups according to tumor immune microenvironment cell-infiltrating characteristics.Results: A composite score was determined based on indicated that immune-related gene prognostic index and m6A risk score. Head and neck squamous cell carcinoma patients in the cancer genome atlas were divided into four subgroups: A (IRGPI-High&m6A-risk-High, n = 127), B (IRGPI-High&m6A-risk-Low, n = 99), C (IRGPI-Low&m6A-risk-High, n = 99), and D (IRGPI-Low&m6A-risk-Low, n = 128), and overall survival (OS) was significantly different between subgroups (p < 0.001). The characteristics of tumor immune microenvironment cell infiltration in the four subgroups were significantly different in subgroups (p < 0.05). The receiver operating characteristic (ROC) curves show the predictive value of composite score for overall survival was superior to other scores.Conclusion: The composite score is a promising prognostic signature which might distinguish immune and molecular characteristics, predict prognosis, and guide more effective immunotherapeutic strategies for head and neck squamous cell carcinoma. |
| first_indexed | 2024-04-10T16:23:47Z |
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| language | English |
| last_indexed | 2024-04-10T16:23:47Z |
| publishDate | 2023-02-01 |
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| series | Frontiers in Genetics |
| spelling | doaj.art-ab41fa870e094ec59e08862bb0d7104b2023-02-09T10:26:43ZengFrontiers Media S.A.Frontiers in Genetics1664-80212023-02-011410.3389/fgene.2023.10615691061569A composite score based on immune-related gene prognostic index and m6A risk score of head and neck squamous cell carcinomaYizhou Yang0Yizhou Yang1Yizhou Yang2Zeman Cai3Kaichun Huang4Mei Li5Xiao Wang6Xiao Wang7Xiao Wang8Yinbing Lin9Yinbing Lin10Yinbing Lin11Sijie Chen12Sijie Chen13Sijie Chen14Zhining Yang15Zhining Yang16Zhixiong Lin17Zhixiong Lin18Zhixiong Lin19Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaNasopharyngeal Carcinoma Research Center of Shantou University Medical College, Shantou, Guangdong, ChinaShantou University Medical College, Shantou, Guangdong, ChinaDepartment of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaDepartment of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaDepartment of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaDepartment of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaNasopharyngeal Carcinoma Research Center of Shantou University Medical College, Shantou, Guangdong, ChinaShantou University Medical College, Shantou, Guangdong, ChinaDepartment of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaNasopharyngeal Carcinoma Research Center of Shantou University Medical College, Shantou, Guangdong, ChinaShantou University Medical College, Shantou, Guangdong, ChinaDepartment of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaNasopharyngeal Carcinoma Research Center of Shantou University Medical College, Shantou, Guangdong, ChinaShantou University Medical College, Shantou, Guangdong, ChinaDepartment of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaNasopharyngeal Carcinoma Research Center of Shantou University Medical College, Shantou, Guangdong, ChinaDepartment of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaNasopharyngeal Carcinoma Research Center of Shantou University Medical College, Shantou, Guangdong, ChinaShantou University Medical College, Shantou, Guangdong, ChinaBackground: Immunotherapy has been demonstrated favorable in head and neck squamous cell carcinoma (HNSCC). Studies indicated that immune-related gene prognostic index (IRGPI) was a robust signature, and N6-methyladenosine (m6A) methylation had a significant impact on the tumor immune microenvironment (TIME) and immunotherapy of head and neck squamous cell carcinoma. Thus, combining indicated that immune-related gene prognostic index with m6A status should offer a better predictive power for immune responses.Methods: Head and neck squamous cell carcinoma samples from the cancer genome atlas (TCGA, n = 498) and gene expression omnibus database (GSE65858, n = 270) were used in this study. Cox regression analysis was used to construct the indicated that immune-related gene prognostic index through immune-related hub genes which were identified by weighted gene co-expression network analysis (WGCNA). The m6A risk score was constructed by least absolute shrinkage and selection operator (LASSO) regression analysis. Principal component analysis was used to construct a composite score, and systematically correlate subgroups according to tumor immune microenvironment cell-infiltrating characteristics.Results: A composite score was determined based on indicated that immune-related gene prognostic index and m6A risk score. Head and neck squamous cell carcinoma patients in the cancer genome atlas were divided into four subgroups: A (IRGPI-High&m6A-risk-High, n = 127), B (IRGPI-High&m6A-risk-Low, n = 99), C (IRGPI-Low&m6A-risk-High, n = 99), and D (IRGPI-Low&m6A-risk-Low, n = 128), and overall survival (OS) was significantly different between subgroups (p < 0.001). The characteristics of tumor immune microenvironment cell infiltration in the four subgroups were significantly different in subgroups (p < 0.05). The receiver operating characteristic (ROC) curves show the predictive value of composite score for overall survival was superior to other scores.Conclusion: The composite score is a promising prognostic signature which might distinguish immune and molecular characteristics, predict prognosis, and guide more effective immunotherapeutic strategies for head and neck squamous cell carcinoma.https://www.frontiersin.org/articles/10.3389/fgene.2023.1061569/fullhead and neck squamous cell carcinomam6Aimmunotherapytumor immune microenvironmentprognosis |
| spellingShingle | Yizhou Yang Yizhou Yang Yizhou Yang Zeman Cai Kaichun Huang Mei Li Xiao Wang Xiao Wang Xiao Wang Yinbing Lin Yinbing Lin Yinbing Lin Sijie Chen Sijie Chen Sijie Chen Zhining Yang Zhining Yang Zhixiong Lin Zhixiong Lin Zhixiong Lin A composite score based on immune-related gene prognostic index and m6A risk score of head and neck squamous cell carcinoma Frontiers in Genetics head and neck squamous cell carcinoma m6A immunotherapy tumor immune microenvironment prognosis |
| title | A composite score based on immune-related gene prognostic index and m6A risk score of head and neck squamous cell carcinoma |
| title_full | A composite score based on immune-related gene prognostic index and m6A risk score of head and neck squamous cell carcinoma |
| title_fullStr | A composite score based on immune-related gene prognostic index and m6A risk score of head and neck squamous cell carcinoma |
| title_full_unstemmed | A composite score based on immune-related gene prognostic index and m6A risk score of head and neck squamous cell carcinoma |
| title_short | A composite score based on immune-related gene prognostic index and m6A risk score of head and neck squamous cell carcinoma |
| title_sort | composite score based on immune related gene prognostic index and m6a risk score of head and neck squamous cell carcinoma |
| topic | head and neck squamous cell carcinoma m6A immunotherapy tumor immune microenvironment prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2023.1061569/full |
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