GILT: shaping the MHC class II-restricted peptidome and CD4+ T cell-mediated immunity
The MHC class II-restricted antigen processing pathway generates peptide:MHC complexes in the endocytic pathway for the activation of CD4+ T cells. Gamma-interferon-inducible lysosomal thiol reductase (GILT) reduces protein disulfide bonds in the endocytic compartment, thereby exposing buried epito...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00429/full |
| _version_ | 1818112631028842496 |
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| author | Karen Taraszka Hastings |
| author_facet | Karen Taraszka Hastings |
| author_sort | Karen Taraszka Hastings |
| collection | DOAJ |
| description | The MHC class II-restricted antigen processing pathway generates peptide:MHC complexes in the endocytic pathway for the activation of CD4+ T cells. Gamma-interferon-inducible lysosomal thiol reductase (GILT) reduces protein disulfide bonds in the endocytic compartment, thereby exposing buried epitopes for MHC class II binding and presentation. T cell hybridoma responses and elution of MHC class II bound peptides have identified GILT-dependent epitopes, GILT-independent epitopes, and epitopes that are more efficiently presented in the absence of GILT termed GILT-prevented epitopes. GILT-mediated alteration in the MHC class II-restricted peptidome modulates T cell development in the thymus and peripheral tolerance and influences the pathogenesis of autoimmunity. Recent studies suggest an emerging role for GILT in the response to pathogens and cancer survival. |
| first_indexed | 2024-12-11T03:22:00Z |
| format | Article |
| id | doaj.art-ab424a32aae24b7baea5f117306cef60 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T03:22:00Z |
| publishDate | 2013-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ab424a32aae24b7baea5f117306cef602022-12-22T01:22:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-12-01410.3389/fimmu.2013.0042968386GILT: shaping the MHC class II-restricted peptidome and CD4+ T cell-mediated immunityKaren Taraszka Hastings0University of Arizona College of Medicine PhoenixThe MHC class II-restricted antigen processing pathway generates peptide:MHC complexes in the endocytic pathway for the activation of CD4+ T cells. Gamma-interferon-inducible lysosomal thiol reductase (GILT) reduces protein disulfide bonds in the endocytic compartment, thereby exposing buried epitopes for MHC class II binding and presentation. T cell hybridoma responses and elution of MHC class II bound peptides have identified GILT-dependent epitopes, GILT-independent epitopes, and epitopes that are more efficiently presented in the absence of GILT termed GILT-prevented epitopes. GILT-mediated alteration in the MHC class II-restricted peptidome modulates T cell development in the thymus and peripheral tolerance and influences the pathogenesis of autoimmunity. Recent studies suggest an emerging role for GILT in the response to pathogens and cancer survival.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00429/fullAutoimmunityantigen processing and presentationtumor immunityGILTMHC class II |
| spellingShingle | Karen Taraszka Hastings GILT: shaping the MHC class II-restricted peptidome and CD4+ T cell-mediated immunity Frontiers in Immunology Autoimmunity antigen processing and presentation tumor immunity GILT MHC class II |
| title | GILT: shaping the MHC class II-restricted peptidome and CD4+ T cell-mediated immunity |
| title_full | GILT: shaping the MHC class II-restricted peptidome and CD4+ T cell-mediated immunity |
| title_fullStr | GILT: shaping the MHC class II-restricted peptidome and CD4+ T cell-mediated immunity |
| title_full_unstemmed | GILT: shaping the MHC class II-restricted peptidome and CD4+ T cell-mediated immunity |
| title_short | GILT: shaping the MHC class II-restricted peptidome and CD4+ T cell-mediated immunity |
| title_sort | gilt shaping the mhc class ii restricted peptidome and cd4 t cell mediated immunity |
| topic | Autoimmunity antigen processing and presentation tumor immunity GILT MHC class II |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00429/full |
| work_keys_str_mv | AT karentaraszkahastings giltshapingthemhcclassiirestrictedpeptidomeandcd4tcellmediatedimmunity |