GILT: shaping the MHC class II-restricted peptidome and CD4+ T cell-mediated immunity

GILT: shaping the MHC class II-restricted peptidome and CD4+ T cell-mediated immunity

The MHC class II-restricted antigen processing pathway generates peptide:MHC complexes in the endocytic pathway for the activation of CD4+ T cells. Gamma-interferon-inducible lysosomal thiol reductase (GILT) reduces protein disulfide bonds in the endocytic compartment, thereby exposing buried epito...

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Bibliographic Details
Main Author:	Karen Taraszka Hastings
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2013-12-01
Series:	Frontiers in Immunology
Subjects:	Autoimmunity antigen processing and presentation tumor immunity GILT MHC class II
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00429/full

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