Novel autoantibodies in rheumatoid arthritis
Rheumatoid factor and antibodies against cyclic citrullinated peptides represent a diagnostic hallmark in rheumatoid arthritis (RA). However, over the last decades many other autoantibodies have been identified. Several proteins can trigger an aberrant autoimmune response in their native form while...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2019-04-01
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| Series: | Reumatismo |
| Subjects: | |
| Online Access: | https://www.reumatismo.org/index.php/reuma/article/view/1102 |
| _version_ | 1818532941007945728 |
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| author | A.F. Bonifacio A. Alunno G.M.C. La Paglia E. Valentini M.C. Leone E. Bartoloni Roberto Gerli |
| author_facet | A.F. Bonifacio A. Alunno G.M.C. La Paglia E. Valentini M.C. Leone E. Bartoloni Roberto Gerli |
| author_sort | A.F. Bonifacio |
| collection | DOAJ |
| description | Rheumatoid factor and antibodies against cyclic citrullinated peptides represent a diagnostic hallmark in rheumatoid arthritis (RA). However, over the last decades many other autoantibodies have been identified. Several proteins can trigger an aberrant autoimmune response in their native form while others acquire this feature after post-translational modifications such as citrullination, carbamylation or acetylation. It is of interest that also the enzymes catalyzing such post-translational modifications (e.g. the protein arginine deiminases) can transform themselves into autoantibodies in RA. The purpose of this review article is to provide an overview of relevant literature published over the last years regarding novel autoantibodies and their possible diagnostic and prognostic significance in RA. |
| first_indexed | 2024-12-11T17:52:06Z |
| format | Article |
| id | doaj.art-ab43ab30d90e4582b04e63e81cfe9e02 |
| institution | Directory Open Access Journal |
| issn | 0048-7449 2240-2683 |
| language | English |
| last_indexed | 2024-12-11T17:52:06Z |
| publishDate | 2019-04-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Reumatismo |
| spelling | doaj.art-ab43ab30d90e4582b04e63e81cfe9e022022-12-22T00:56:11ZengPAGEPress PublicationsReumatismo0048-74492240-26832019-04-0171110.4081/reumatismo.2019.1102Novel autoantibodies in rheumatoid arthritisA.F. Bonifacio0A. Alunno1G.M.C. La Paglia2E. Valentini3M.C. Leone4E. Bartoloni5Roberto Gerli6Rheumatology Unit, Department of Medicine, University of PerugiaRheumatology Unit, Department of Medicine, University of PerugiaRheumatology Unit, Department of Medicine, University of PerugiaRheumatology Unit, Department of Medicine, University of PerugiaRheumatology Unit, Department of Medicine, University of PerugiaRheumatology Unit, Department of Medicine, University of PerugiaRheumatology Unit, Department of Medicine, University of PerugiaRheumatoid factor and antibodies against cyclic citrullinated peptides represent a diagnostic hallmark in rheumatoid arthritis (RA). However, over the last decades many other autoantibodies have been identified. Several proteins can trigger an aberrant autoimmune response in their native form while others acquire this feature after post-translational modifications such as citrullination, carbamylation or acetylation. It is of interest that also the enzymes catalyzing such post-translational modifications (e.g. the protein arginine deiminases) can transform themselves into autoantibodies in RA. The purpose of this review article is to provide an overview of relevant literature published over the last years regarding novel autoantibodies and their possible diagnostic and prognostic significance in RA.https://www.reumatismo.org/index.php/reuma/article/view/1102Rheumatoid arthritisAutoantibodiesCitrullination. |
| spellingShingle | A.F. Bonifacio A. Alunno G.M.C. La Paglia E. Valentini M.C. Leone E. Bartoloni Roberto Gerli Novel autoantibodies in rheumatoid arthritis Reumatismo Rheumatoid arthritis Autoantibodies Citrullination. |
| title | Novel autoantibodies in rheumatoid arthritis |
| title_full | Novel autoantibodies in rheumatoid arthritis |
| title_fullStr | Novel autoantibodies in rheumatoid arthritis |
| title_full_unstemmed | Novel autoantibodies in rheumatoid arthritis |
| title_short | Novel autoantibodies in rheumatoid arthritis |
| title_sort | novel autoantibodies in rheumatoid arthritis |
| topic | Rheumatoid arthritis Autoantibodies Citrullination. |
| url | https://www.reumatismo.org/index.php/reuma/article/view/1102 |
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