A Case-Control Analysis of the Impact of Venous Thromboembolic Disease on Quality of Life of Patients with Cancer: Quality of Life in Cancer (Qca) Study
Although there is published research on the impact of venous thromboembolism (VTE) on quality of life (QoL), this issue has not been thoroughly investigated in patients with cancer—particularly using specific questionnaires. We aimed to examine the impact of acute symptomatic VTE on QoL of...
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MDPI AG
2019-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/1/75 |
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| author | Lucia Marin-Barrera Andres J. Muñoz-Martin Eduardo Rios-Herranz Ignacio Garcia-Escobar Carmen Beato Carme Font Estefania Oncala-Sibajas Alfonso Revuelta-Rodriguez Maria Carmen Areses Victor Rivas-Jimenez Maria Angeles Moreno-Santos Aitor Ballaz-Quincoces Juan-Bosco Lopez-Saez Iria Gallego Teresa Elias-Hernandez Maria Isabel Asensio-Cruz Leyre Chasco-Eguilaz Gonzalo Garcia-Gonzalez Purificacion Estevez-Garcia Remedios Otero Jorge Lima-Alvarez Luis Jara-Palomares |
| author_facet | Lucia Marin-Barrera Andres J. Muñoz-Martin Eduardo Rios-Herranz Ignacio Garcia-Escobar Carmen Beato Carme Font Estefania Oncala-Sibajas Alfonso Revuelta-Rodriguez Maria Carmen Areses Victor Rivas-Jimenez Maria Angeles Moreno-Santos Aitor Ballaz-Quincoces Juan-Bosco Lopez-Saez Iria Gallego Teresa Elias-Hernandez Maria Isabel Asensio-Cruz Leyre Chasco-Eguilaz Gonzalo Garcia-Gonzalez Purificacion Estevez-Garcia Remedios Otero Jorge Lima-Alvarez Luis Jara-Palomares |
| author_sort | Lucia Marin-Barrera |
| collection | DOAJ |
| description | Although there is published research on the impact of venous thromboembolism (VTE) on quality of life (QoL), this issue has not been thoroughly investigated in patients with cancer—particularly using specific questionnaires. We aimed to examine the impact of acute symptomatic VTE on QoL of patients with malignancies. This was a multicenter, prospective, case-control study conducted in patients with cancer either with (cases) or without (controls) acute symptomatic VTE. Participants completed the EORTC QLQ-C30, EQ-5D-3L, PEmb-QoL, and VEINES-QOL/Sym questionnaires. Statistically significant and clinically relevant differences in terms of global health status were examined. Between 2015 and 2018, we enrolled 425 patients (128 cases and 297 controls; mean age: 60.2 ± 18.4 years). The most common malignancies were gastrointestinal (23.5%) and lung (19.8%) tumors. We found minimally important differences in global health status on the EQ-5D-3L (cases versus controls: 0.55 versus 0.77; mean difference: −0.22) and EORTC QLQ-C30 (47.7 versus 58.4; mean difference: −10.3) questionnaires. There were minimally important differences on the PEmb-QoL questionnaire (44.4 versus 23; mean difference: −21.4) and a significantly worse QoL on the VEINES-QOL/Sym questionnaire (42.7 versus 51.7; mean difference: −9). In conclusion, we showed that acute symptomatic VTE adversely affects the QoL of patients with malignancies. |
| first_indexed | 2024-03-12T19:48:25Z |
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| id | doaj.art-ab46065c4b024f46be47fee4679dbedb |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T19:48:25Z |
| publishDate | 2019-12-01 |
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| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ab46065c4b024f46be47fee4679dbedb2023-08-02T03:24:52ZengMDPI AGCancers2072-66942019-12-011217510.3390/cancers12010075cancers12010075A Case-Control Analysis of the Impact of Venous Thromboembolic Disease on Quality of Life of Patients with Cancer: Quality of Life in Cancer (Qca) StudyLucia Marin-Barrera0Andres J. Muñoz-Martin1Eduardo Rios-Herranz2Ignacio Garcia-Escobar3Carmen Beato4Carme Font5Estefania Oncala-Sibajas6Alfonso Revuelta-Rodriguez7Maria Carmen Areses8Victor Rivas-Jimenez9Maria Angeles Moreno-Santos10Aitor Ballaz-Quincoces11Juan-Bosco Lopez-Saez12Iria Gallego13Teresa Elias-Hernandez14Maria Isabel Asensio-Cruz15Leyre Chasco-Eguilaz16Gonzalo Garcia-Gonzalez17Purificacion Estevez-Garcia18Remedios Otero19Jorge Lima-Alvarez20Luis Jara-Palomares21Respiratory Department, Medical Surgical Unit of Respiratory Diseases, Hospital Virgen del Rocio, CIBERES, 41013 Sevilla, SpainMedical Oncology Department, Hospital General Universitario Gregorio Marañón, 28009 Madrid, SpainHematology and Hemotherapy Department, Hospital Universitario Virgen de Valme, 41701 Sevilla, SpainMedical Oncology Department, HGU de Ciudad Real, 13003 Ciudad Real, SpainMedical Oncology Department, Hospital Universitario Virgen Macarena, 41009 Sevilla, SpainMedical Oncology Department, DIBAPS/Translational Genomics and Targeted Therapeutics in Solid Tumors, Hospital Clínic, 08036 Barcelona, SpainEmergency Department, Hospital Virgen Macarena, 41009 Sevilla, SpainMedical Oncology Department, Hospital Universitario Central de Asturias, 33611 Oviedo, SpainMedical Oncology Department, Hospital de Orense, 32616 Orense, SpainMedical Oncology Department, Hospital de Jerez de la Frontera, 11407 Cádiz, SpainMedical Oncology Department, H. U. Puerto Real, 11510 Cádiz, SpainRespiratory Department, Hospital de Galdakao-Usansolo, 48960 Bizkaia, SpainInternal Medicine Unit. H. U. Puerto Real, 11510 Cádiz, SpainMedical Oncology Department, Hospital General Universitario Gregorio Marañón, 28009 Madrid, SpainRespiratory Department, Medical Surgical Unit of Respiratory Diseases, Hospital Virgen del Rocio, CIBERES, 41013 Sevilla, SpainRespiratory Department, Medical Surgical Unit of Respiratory Diseases, Hospital Virgen del Rocio, CIBERES, 41013 Sevilla, SpainRespiratory Department, Hospital de Galdakao-Usansolo, 48960 Bizkaia, SpainMedical Oncology Department, Hospital General Universitario Gregorio Marañón, 28009 Madrid, SpainMedical Oncology Department, Hospital Virgen del Rocio, 41013 Sevilla, SpainRespiratory Department, Medical Surgical Unit of Respiratory Diseases, Hospital Virgen del Rocio, CIBERES, 41013 Sevilla, SpainRespiratory Department, Hospital Universitario Virgen de Valme, 41701 Sevilla, SpainRespiratory Department, Medical Surgical Unit of Respiratory Diseases, Hospital Virgen del Rocio, CIBERES, 41013 Sevilla, SpainAlthough there is published research on the impact of venous thromboembolism (VTE) on quality of life (QoL), this issue has not been thoroughly investigated in patients with cancer—particularly using specific questionnaires. We aimed to examine the impact of acute symptomatic VTE on QoL of patients with malignancies. This was a multicenter, prospective, case-control study conducted in patients with cancer either with (cases) or without (controls) acute symptomatic VTE. Participants completed the EORTC QLQ-C30, EQ-5D-3L, PEmb-QoL, and VEINES-QOL/Sym questionnaires. Statistically significant and clinically relevant differences in terms of global health status were examined. Between 2015 and 2018, we enrolled 425 patients (128 cases and 297 controls; mean age: 60.2 ± 18.4 years). The most common malignancies were gastrointestinal (23.5%) and lung (19.8%) tumors. We found minimally important differences in global health status on the EQ-5D-3L (cases versus controls: 0.55 versus 0.77; mean difference: −0.22) and EORTC QLQ-C30 (47.7 versus 58.4; mean difference: −10.3) questionnaires. There were minimally important differences on the PEmb-QoL questionnaire (44.4 versus 23; mean difference: −21.4) and a significantly worse QoL on the VEINES-QOL/Sym questionnaire (42.7 versus 51.7; mean difference: −9). In conclusion, we showed that acute symptomatic VTE adversely affects the QoL of patients with malignancies.https://www.mdpi.com/2072-6694/12/1/75neoplasmquality of lifevenous thromboembolismpulmonary embolismvenous thrombosis |
| spellingShingle | Lucia Marin-Barrera Andres J. Muñoz-Martin Eduardo Rios-Herranz Ignacio Garcia-Escobar Carmen Beato Carme Font Estefania Oncala-Sibajas Alfonso Revuelta-Rodriguez Maria Carmen Areses Victor Rivas-Jimenez Maria Angeles Moreno-Santos Aitor Ballaz-Quincoces Juan-Bosco Lopez-Saez Iria Gallego Teresa Elias-Hernandez Maria Isabel Asensio-Cruz Leyre Chasco-Eguilaz Gonzalo Garcia-Gonzalez Purificacion Estevez-Garcia Remedios Otero Jorge Lima-Alvarez Luis Jara-Palomares A Case-Control Analysis of the Impact of Venous Thromboembolic Disease on Quality of Life of Patients with Cancer: Quality of Life in Cancer (Qca) Study Cancers neoplasm quality of life venous thromboembolism pulmonary embolism venous thrombosis |
| title | A Case-Control Analysis of the Impact of Venous Thromboembolic Disease on Quality of Life of Patients with Cancer: Quality of Life in Cancer (Qca) Study |
| title_full | A Case-Control Analysis of the Impact of Venous Thromboembolic Disease on Quality of Life of Patients with Cancer: Quality of Life in Cancer (Qca) Study |
| title_fullStr | A Case-Control Analysis of the Impact of Venous Thromboembolic Disease on Quality of Life of Patients with Cancer: Quality of Life in Cancer (Qca) Study |
| title_full_unstemmed | A Case-Control Analysis of the Impact of Venous Thromboembolic Disease on Quality of Life of Patients with Cancer: Quality of Life in Cancer (Qca) Study |
| title_short | A Case-Control Analysis of the Impact of Venous Thromboembolic Disease on Quality of Life of Patients with Cancer: Quality of Life in Cancer (Qca) Study |
| title_sort | case control analysis of the impact of venous thromboembolic disease on quality of life of patients with cancer quality of life in cancer qca study |
| topic | neoplasm quality of life venous thromboembolism pulmonary embolism venous thrombosis |
| url | https://www.mdpi.com/2072-6694/12/1/75 |
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