Recent Advances in the Heterologous Biosynthesis of Natural Products from <i>Streptomyces</i>

Recent Advances in the Heterologous Biosynthesis of Natural Products from <i>Streptomyces</i>

<i>Streptomyces</i> is a significant source of natural products that are used as therapeutic antibiotics, anticancer and antitumor agents, pesticides, and dyes. Recently, with the advances in metabolite analysis, many new secondary metabolites have been characterized. Moreover, genome mi...

Full description

Bibliographic Details
Main Authors:	Van Thuy Thi Pham, Chung Thanh Nguyen, Dipesh Dhakal, Hue Thi Nguyen, Tae-Su Kim, Jae Kyung Sohng
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Series:	Applied Sciences
Subjects:	heterologous expression <i>Streptomyces</i> secondary metabolite
Online Access:	https://www.mdpi.com/2076-3417/11/4/1851

Similar Items

Recent Advances in Strategies for Activation and Discovery/Characterization of Cryptic Biosynthetic Gene Clusters in <i>Streptomyces</i>
by: Chung Thanh Nguyen, et al.
Published: (2020-04-01)

Heterologous Expression of Type II PKS Gene Cluster Leads to Diversified Angucyclines in <i>Streptomyces albus</i> J1074
by: Xiaoting Zhang, et al.
Published: (2024-10-01)

Dudomycins: New Secondary Metabolites Produced after Heterologous Expression of an Nrps Cluster from <i>Streptomyces albus</i> ssp. <i>Chlorinus</i> Nrrl B-24108
by: Constanze Lasch, et al.
Published: (2020-11-01)

Regulatory Control of Rishirilide(s) Biosynthesis in <i>Streptomyces bottropensis</i>
by: Olga Tsypik, et al.
Published: (2021-02-01)

Increasing the heterologous production of spinosad in Streptomyces albus J1074 by regulating biosynthesis of its polyketide skeleton
by: Ziheng An, et al.
Published: (2021-12-01)

An Overview of Lsr2 Repressor Effect in <i>Streptomyces</i> spp. Secondary Metabolism
by: Lorena Cuervo, et al.
Published: (2024-11-01)

Functional Analysis of P450 Monooxygenase SrrO in the Biosynthesis of Butenolide-Type Signaling Molecules in <i>Streptomyces</i> <i>rochei</i>
by: Aiko Teshima, et al.
Published: (2020-08-01)

Miramides A–D: Identification of Detoxin-like Depsipeptides after Heterologous Expression of a Hybrid NRPS-PKS Gene Cluster from <i>Streptomyces mirabilis</i> Lu17588
by: Constanze Paulus, et al.
Published: (2022-08-01)

Co-Expression of Transcriptional Regulators and Housekeeping Genes in <i>Streptomyces</i> spp.: A Strategy to Optimize Metabolite Production
by: Lorena Cuervo, et al.
Published: (2023-06-01)

Isolation and Identification of Pentalenolactone Analogs from <i>Streptomyces</i> sp. NRRL S-4
by: Huanhuan Li, et al.
Published: (2021-12-01)

The Onset of Tacrolimus Biosynthesis in <i>Streptomyces tsukubaensis</i> Is Dependent on the Intracellular Redox Status
by: Sílvia D. S. Pires, et al.
Published: (2020-10-01)

Flavacol and Its Novel Derivative 3-<i>β</i>-Hydroxy Flavacol from <i>Streptomyces</i> sp. Pv 4-95 after the Expression of Heterologous AdpA
by: Stepan Tistechok, et al.
Published: (2022-11-01)

Analysis of Secondary Metabolite Synthesis Potential of <i>Streptomyces fradiae</i> sf106 Based on the Whole Genome and Non-Target Metabolomics and Exploration of the Biosynthesis of Tylosin
by: Chenbo Jia, et al.
Published: (2023-09-01)

Application of Gene Knockout and Heterologous Expression Strategy in Fungal Secondary Metabolites Biosynthesis
by: Yaodong Ning, et al.
Published: (2022-11-01)

Genome Shuffling Mutant of <i>Streptomyces diastatochromogenes</i> for Substantial Improvement of Toyocamycin Production
by: Yang Song, et al.
Published: (2022-10-01)

Characterization of Regulatory and Transporter Genes in the Biosynthesis of Anti-Tuberculosis Ilamycins and Production in a Heterologous Host
by: Jianqiao He, et al.
Published: (2020-04-01)

Discovery and Heterologous Production of New Cyclic Depsibosamycins
by: Marc Stierhof, et al.
Published: (2021-06-01)

Biosynthesis and Heterologous Expression of Cacaoidin, the First Member of the Lanthidin Family of RiPPs
by: Fernando Román-Hurtado, et al.
Published: (2021-04-01)

Bonsecamin: A New Cyclic Pentapeptide Discovered through Heterologous Expression of a Cryptic Gene Cluster
by: Constanze Lasch, et al.
Published: (2021-07-01)

Characterization of the Antibacterial Activity of Quinone-Based Compounds Originating from the Alnumycin Biosynthetic Gene Cluster of a <i>Streptomyces</i> Isolate
by: Leonie Sagurna, et al.
Published: (2023-06-01)

Strain <i>Streptomyces</i> sp. P-56 Produces Nonactin and Possesses Insecticidal, Acaricidal, Antimicrobial and Plant Growth-Promoting Traits
by: Irina Boykova, et al.
Published: (2023-03-01)

Whole Genome Analysis and Assessment of the Metabolic Potential of <i>Streptomyces carpaticus</i> SCPM-O-B-9993, a Promising Phytostimulant and Antiviral Agent
by: Yulia Bataeva, et al.
Published: (2024-05-01)

A Multidisciplinary Approach to Unraveling the Natural Product Biosynthetic Potential of a <i>Streptomyces</i> Strain Collection Isolated from Leaf-Cutting Ants
by: Ana Ceniceros, et al.
Published: (2021-10-01)

Investigating the Stirred Tank Bioreactor Co-Cultures of the Secondary Metabolite Producers <i>Streptomyces noursei</i> and <i>Penicillium rubens</i>
by: Tomasz Boruta, et al.
Published: (2023-12-01)

Properties of Multidrug-Resistant Mutants Derived from Heterologous Expression Chassis Strain <i>Streptomyces albidoflavus</i> J1074
by: Borys Dolya, et al.
Published: (2023-04-01)

In silico and in vitro analyses reveal the potential use of Streptomyces parvulus VNUA74 as bioagent for sustainable banana production
by: Trung Thanh Nguyen, et al.
Published: (2025-02-01)

The Discovery of Weddellamycin, a Tricyclic Polyene Macrolactam Antibiotic from an Antarctic Deep-Sea-Derived <i>Streptomyces</i> sp. DSS69, by Heterologous Expression
by: Lu Chen, et al.
Published: (2024-04-01)

Study on the effect of metabolites secondary of Streptomyces on the bacterium Pseudomonas aeruginosa isolated from dog’s wound
by: Sara Abdulkareem Raheem, et al.
Published: (2024-12-01)

Biosynthesis of (±)-Differolide, an Antioxidant Isolate from <i>Streptomyces qaidamensis</i> S10<sup>T</sup>
by: Yujie Wu, et al.
Published: (2022-04-01)

Stepwise increase of fidaxomicin in an engineered heterologous host Streptomyces albus through multi-level metabolic engineering
by: Huang Xie, et al.
Published: (2024-12-01)

In Silico Prediction of Secondary Metabolites and Biosynthetic Gene Clusters Analysis of <i>Streptomyces thinghirensis</i> HM3 Isolated from Arid Soil
by: Medhat Rehan, et al.
Published: (2023-01-01)

A Genomics-Based Discovery of Secondary Metabolite Biosynthetic Gene Clusters in the Potential Novel Strain <i>Streptomyces</i> sp. 21So2-11 Isolated from Antarctic Soil
by: Yu Du, et al.
Published: (2024-06-01)

Enhanced Oxytetracycline Production by <i>Streptomyces rimosus</i> in Submerged Co-Cultures with <i>Streptomyces noursei</i>
by: Tomasz Boruta, et al.
Published: (2021-10-01)

Reconstitution of Polyketide-Derived Meroterpenoid Biosynthetic Pathway in <i>Aspergillus oryzae</i>
by: Takayoshi Awakawa, et al.
Published: (2021-06-01)

The Nonribosomal Peptide Valinomycin: From Discovery to Bioactivity and Biosynthesis
by: Shuhui Huang, et al.
Published: (2021-04-01)

Genomic and Metabolomic Investigation of a Rhizosphere Isolate <i>Streptomyces netropsis</i> WLXQSS-4 Associated with a Traditional Chinese Medicine
by: Songya Zhang, et al.
Published: (2021-04-01)

Antagonistic Activity of <i>Streptomyces alfalfae</i> 11F against <i>Fusarium</i> Wilt of Watermelon and Transcriptome Analysis Provides Insights into the Synthesis of Phenazine-1-Carboxamide
by: Dan Dong, et al.
Published: (2023-11-01)

Antibiotic Biosynthesis Pathways from Endophytic <i>Streptomyces</i> SUK 48 through Metabolomics and Genomics Approaches
by: Mohd Shukri Baba, et al.
Published: (2021-08-01)

Effect of PAS-LuxR Family Regulators on the Secondary Metabolism of <i>Streptomyces</i>
by: Naifan Zhang, et al.
Published: (2022-12-01)

Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers
by: Qian Deng, et al.
Published: (2017-03-01)