Incidental prostate cancer in transurethral resection of prostate specimens in men aged up to 65 years
Background: The identification of prostate cancer (PC) is important in men aged ≤ 65 years. We examined complete transurethral resection of prostate (TURP) specimens to quantify the incidence and nature of PC in men aged ≤ 65 years. Methods: A prospective multi-institutional database included TURP s...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-03-01
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| Series: | Prostate International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2287888215300763 |
| _version_ | 1797726946887467008 |
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| author | Marlon Perera Nathan Lawrentschuk Nayomi Perera Damien Bolton David Clouston |
| author_facet | Marlon Perera Nathan Lawrentschuk Nayomi Perera Damien Bolton David Clouston |
| author_sort | Marlon Perera |
| collection | DOAJ |
| description | Background: The identification of prostate cancer (PC) is important in men aged ≤ 65 years. We examined complete transurethral resection of prostate (TURP) specimens to quantify the incidence and nature of PC in men aged ≤ 65 years.
Methods: A prospective multi-institutional database included TURP specimens. The cohort was stratified into two groups according to age. For men aged ≤ 65 years, the entire specimen was submitted for histological analysis, while the TURP specimens from men aged > 65 years were sampled following standard guidelines.
Results: A total of 923 men were included, with 224 in the younger group. PC was identified in 13.4% in men aged ≤ 65 years, compared with 28.7% the older group. The younger group had a lower proportion of Gleason score ≥ 7 (30% compared with 40%) and higher rates of pT1a (57% compared with 43%). In men aged ≤ 65 years with cancer, tumor was identified in one block in 15 of 30 cases (50%). Following diagnosis, 4/30 underwent radical prostatectomy, 5/30 underwent curative radiotherapy, 10/30 androgen deprivation, and 1/30 received palliative radiotherapy.
Conclusion: Incidental PC in men aged ≤ 65 years is not uncommon. Our results suggest that TURP specimens in men aged ≤ 65 years should be completely assessed. Underidentification of cancer may occur as a result of increasing use of laser prostatectomy and the consequent loss of tissue for pathological examination. |
| first_indexed | 2024-03-12T10:52:46Z |
| format | Article |
| id | doaj.art-ab477096bdf2487ba6a6855523628a73 |
| institution | Directory Open Access Journal |
| issn | 2287-8882 |
| language | English |
| last_indexed | 2024-03-12T10:52:46Z |
| publishDate | 2016-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Prostate International |
| spelling | doaj.art-ab477096bdf2487ba6a6855523628a732023-09-02T06:50:18ZengElsevierProstate International2287-88822016-03-0141111410.1016/j.prnil.2015.10.016Incidental prostate cancer in transurethral resection of prostate specimens in men aged up to 65 yearsMarlon Perera0Nathan Lawrentschuk1Nayomi Perera2Damien Bolton3David Clouston4School of Medicine, University of Queensland, St Lucia, QLD, AustraliaDepartment of Surgery, University of Melbourne, VIC, AustraliaDepartment of Surgery, University of Melbourne, VIC, AustraliaDepartment of Surgery, University of Melbourne, VIC, AustraliaTissue Path, Glen Waverly, VIC, AustraliaBackground: The identification of prostate cancer (PC) is important in men aged ≤ 65 years. We examined complete transurethral resection of prostate (TURP) specimens to quantify the incidence and nature of PC in men aged ≤ 65 years. Methods: A prospective multi-institutional database included TURP specimens. The cohort was stratified into two groups according to age. For men aged ≤ 65 years, the entire specimen was submitted for histological analysis, while the TURP specimens from men aged > 65 years were sampled following standard guidelines. Results: A total of 923 men were included, with 224 in the younger group. PC was identified in 13.4% in men aged ≤ 65 years, compared with 28.7% the older group. The younger group had a lower proportion of Gleason score ≥ 7 (30% compared with 40%) and higher rates of pT1a (57% compared with 43%). In men aged ≤ 65 years with cancer, tumor was identified in one block in 15 of 30 cases (50%). Following diagnosis, 4/30 underwent radical prostatectomy, 5/30 underwent curative radiotherapy, 10/30 androgen deprivation, and 1/30 received palliative radiotherapy. Conclusion: Incidental PC in men aged ≤ 65 years is not uncommon. Our results suggest that TURP specimens in men aged ≤ 65 years should be completely assessed. Underidentification of cancer may occur as a result of increasing use of laser prostatectomy and the consequent loss of tissue for pathological examination.http://www.sciencedirect.com/science/article/pii/S2287888215300763Incidental prostate cancerProstatic neoplasmsRadical prostatectomySurgeryTransurethral resection of prostate |
| spellingShingle | Marlon Perera Nathan Lawrentschuk Nayomi Perera Damien Bolton David Clouston Incidental prostate cancer in transurethral resection of prostate specimens in men aged up to 65 years Prostate International Incidental prostate cancer Prostatic neoplasms Radical prostatectomy Surgery Transurethral resection of prostate |
| title | Incidental prostate cancer in transurethral resection of prostate specimens in men aged up to 65 years |
| title_full | Incidental prostate cancer in transurethral resection of prostate specimens in men aged up to 65 years |
| title_fullStr | Incidental prostate cancer in transurethral resection of prostate specimens in men aged up to 65 years |
| title_full_unstemmed | Incidental prostate cancer in transurethral resection of prostate specimens in men aged up to 65 years |
| title_short | Incidental prostate cancer in transurethral resection of prostate specimens in men aged up to 65 years |
| title_sort | incidental prostate cancer in transurethral resection of prostate specimens in men aged up to 65 years |
| topic | Incidental prostate cancer Prostatic neoplasms Radical prostatectomy Surgery Transurethral resection of prostate |
| url | http://www.sciencedirect.com/science/article/pii/S2287888215300763 |
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