T cell metabolic reprogramming in acute kidney injury and protection by glutamine blockade

T cell metabolic reprogramming in acute kidney injury and protection by glutamine blockade

T cells play an important role in acute kidney injury (AKI). Metabolic programming of T cells regulates their function, is a rapidly emerging field, and is unknown in AKI. We induced ischemic AKI in C57BL/6J mice and collected kidneys and spleens at multiple time points. T cells were isolated and an...

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Bibliographic Details
Main Authors: Kyungho Lee, Elizabeth A. Thompson, Sepideh Gharaie, Chirag H. Patel, Johanna T. Kurzhagen, Phillip M. Pierorazio, Lois J. Arend, Ajit G. Thomas, Sanjeev Noel, Barbara S. Slusher, Hamid Rabb
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-06-01
Series:JCI Insight
Subjects:
Immunology
Nephrology
Online Access:https://doi.org/10.1172/jci.insight.160345

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