A review of preoperative chemoradiotherapy for lower rectal cancer

In Western countries, rectal cancer has been treated by chemoradiotherapy (CRT) for several decades now, and good local control has been reported. However, Japanese guidelines did not strongly recommend CRT, because CRT is only useful for achieving local control and imbues no survival benefit. For t...

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Bibliographic Details
Main Authors: Naohito Beppu, Hidenori Yanagi, Naohiro Tomita
Format: Article
Language:English
Published: The Japan Society of Coloproctology 2017-07-01
Series:Journal of the Anus, Rectum and Colon
Subjects:
Online Access:https://www.jstage.jst.go.jp/article/jarc/1/3/1_2017-013/_pdf/-char/en
Description
Summary:In Western countries, rectal cancer has been treated by chemoradiotherapy (CRT) for several decades now, and good local control has been reported. However, Japanese guidelines did not strongly recommend CRT, because CRT is only useful for achieving local control and imbues no survival benefit. For this reason, CRT was rarely used to treat rectal cancer in Japan. However, in the 2000s, several studies involving CRT began to be reported from Western countries, such as “correlation between pathological complete response and survival,” “induction chemotherapy followed by CRT,” and “watch-and-wait policies.” These studies were directly correlated with survival of and benefits to the patients. Given these findings, Japanese institutions have recently begun to introduce CRT for rectal cancer. Therefore, in the present study, we reviewed several topics regarding CRT for rectal cancer.
ISSN:2432-3853