Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma

Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma

Abstract There is a critical need to identify new therapeutic vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). Transcriptional co-regulators C-terminal binding proteins (CtBP) 1 and 2 are highly overexpressed in human PDAC, and CRISPR-based homozygous deletion of Ctbp2 in a mouse PDAC cel...

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Bibliographic Details
Main Authors: Kranthi Kumar Chougoni, Haemin Park, Priyadarshan K. Damle, Travis Mason, Bo Cheng, Martin M. Dcona, Barbara Szomju, Mikhail G. Dozmorov, Michael O. Idowu, Steven R. Grossman
Format: Article
Language:English
Published: Nature Publishing Group 2023-11-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-023-00498-8

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https://doi.org/10.1038/s41389-023-00498-8

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