Synergistic Effects of Korean Red Ginseng Extract and the Conventional Systemic Therapeutics of Atopic Dermatitis in a Murine Model
The synergistic effects of Korean Red ginseng (KRG, <i>Panax ginseng</i> C.A. Mey.) on conventional systemic therapeutics of atopic dermatitis (AD) have not been studied yet. To analyze the synergistic effects of KRG extract and the conventional systemic therapeutics of AD in TNCB-induce...
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MDPI AG
2021-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/1/133 |
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| author | Yu Ri Woo Seok Hoon Moon Jeesuk Yu Sang Hyun Cho |
| author_facet | Yu Ri Woo Seok Hoon Moon Jeesuk Yu Sang Hyun Cho |
| author_sort | Yu Ri Woo |
| collection | DOAJ |
| description | The synergistic effects of Korean Red ginseng (KRG, <i>Panax ginseng</i> C.A. Mey.) on conventional systemic therapeutics of atopic dermatitis (AD) have not been studied yet. To analyze the synergistic effects of KRG extract and the conventional systemic therapeutics of AD in TNCB-induced AD mouse model, we determined the change in modified scoring of index, the transepidermal water loss, the skin pathology, serum IgE, and the expression of various cytokines after combination treatment to the five-week-old NC/Nga female mice. The severity of AD was significantly decreased in the KRG + hydroxyzine (AH) group than AH group, and in the KRG + evening primrose oil (EPO) group than EPO group. A significant decrease in dermal inflammation was observed in the KRG + AH group than that in the AH group, and in the KRG + EPO group than that in the EPO group (<i>p</i> = 0.008), respectively. A decrease in CD1a expression was observed in the KRG + AH group when compared to the AH group (<i>p</i> = 0.008), and KRG + EPO group when compared to the EPO group. Compared to the CS group, the KRG + CS group showed a significant decrease in IL-17 expression. A combination of KRG and conventional systemic therapeutics can safely and effectively manage the AD. |
| first_indexed | 2024-03-10T03:27:16Z |
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| id | doaj.art-ab4b8285fbbe454c9e2a035abd7c9cd0 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T03:27:16Z |
| publishDate | 2021-12-01 |
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| spelling | doaj.art-ab4b8285fbbe454c9e2a035abd7c9cd02023-11-23T12:04:40ZengMDPI AGNutrients2072-66432021-12-0114113310.3390/nu14010133Synergistic Effects of Korean Red Ginseng Extract and the Conventional Systemic Therapeutics of Atopic Dermatitis in a Murine ModelYu Ri Woo0Seok Hoon Moon1Jeesuk Yu2Sang Hyun Cho3Department of Dermatology, Incheon St. Mary’s Hospital, The Catholic University of Korea, Seoul 06591, KoreaVilla de Skin, Hwaseong 18478, KoreaDepartment of Pediatrics, Dankook University Hospital, Dankook University College of Medicine, Cheonan 31116, KoreaDepartment of Dermatology, Incheon St. Mary’s Hospital, The Catholic University of Korea, Seoul 06591, KoreaThe synergistic effects of Korean Red ginseng (KRG, <i>Panax ginseng</i> C.A. Mey.) on conventional systemic therapeutics of atopic dermatitis (AD) have not been studied yet. To analyze the synergistic effects of KRG extract and the conventional systemic therapeutics of AD in TNCB-induced AD mouse model, we determined the change in modified scoring of index, the transepidermal water loss, the skin pathology, serum IgE, and the expression of various cytokines after combination treatment to the five-week-old NC/Nga female mice. The severity of AD was significantly decreased in the KRG + hydroxyzine (AH) group than AH group, and in the KRG + evening primrose oil (EPO) group than EPO group. A significant decrease in dermal inflammation was observed in the KRG + AH group than that in the AH group, and in the KRG + EPO group than that in the EPO group (<i>p</i> = 0.008), respectively. A decrease in CD1a expression was observed in the KRG + AH group when compared to the AH group (<i>p</i> = 0.008), and KRG + EPO group when compared to the EPO group. Compared to the CS group, the KRG + CS group showed a significant decrease in IL-17 expression. A combination of KRG and conventional systemic therapeutics can safely and effectively manage the AD.https://www.mdpi.com/2072-6643/14/1/133atopic dermatitisantihistaminecyclosporineKorean Red ginsengtreatment |
| spellingShingle | Yu Ri Woo Seok Hoon Moon Jeesuk Yu Sang Hyun Cho Synergistic Effects of Korean Red Ginseng Extract and the Conventional Systemic Therapeutics of Atopic Dermatitis in a Murine Model Nutrients atopic dermatitis antihistamine cyclosporine Korean Red ginseng treatment |
| title | Synergistic Effects of Korean Red Ginseng Extract and the Conventional Systemic Therapeutics of Atopic Dermatitis in a Murine Model |
| title_full | Synergistic Effects of Korean Red Ginseng Extract and the Conventional Systemic Therapeutics of Atopic Dermatitis in a Murine Model |
| title_fullStr | Synergistic Effects of Korean Red Ginseng Extract and the Conventional Systemic Therapeutics of Atopic Dermatitis in a Murine Model |
| title_full_unstemmed | Synergistic Effects of Korean Red Ginseng Extract and the Conventional Systemic Therapeutics of Atopic Dermatitis in a Murine Model |
| title_short | Synergistic Effects of Korean Red Ginseng Extract and the Conventional Systemic Therapeutics of Atopic Dermatitis in a Murine Model |
| title_sort | synergistic effects of korean red ginseng extract and the conventional systemic therapeutics of atopic dermatitis in a murine model |
| topic | atopic dermatitis antihistamine cyclosporine Korean Red ginseng treatment |
| url | https://www.mdpi.com/2072-6643/14/1/133 |
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