CEBPB is associated with active tumor immune environment and favorable prognosis of metastatic skin cutaneous melanoma
Metastatic skin cutaneous melanoma (SKCM) is a common malignancy that accounts for low morbidity but high mortality of skin cancer. SKCM is characterized by high lymphocytic infiltration, whereas the states of infiltrated cells are variable in patients leading to a heterogeneous prognosis and hinder...
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| Format: | Article |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.991797/full |
| _version_ | 1828142766022983680 |
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| author | Jingrun Yang Jingrun Yang Yang Xu Kuixia Xie Ling Gao Wenying Zhong Xinhua Liu Xinhua Liu |
| author_facet | Jingrun Yang Jingrun Yang Yang Xu Kuixia Xie Ling Gao Wenying Zhong Xinhua Liu Xinhua Liu |
| author_sort | Jingrun Yang |
| collection | DOAJ |
| description | Metastatic skin cutaneous melanoma (SKCM) is a common malignancy that accounts for low morbidity but high mortality of skin cancer. SKCM is characterized by high lymphocytic infiltration, whereas the states of infiltrated cells are variable in patients leading to a heterogeneous prognosis and hindering appropriate clinical decisions. It is therefore urgent to identify markers associated with lymphocytic infiltration, cellular conditions, and the prognosis of SKCM. In this study, we report that CEBPB, a transcriptional factor, is mainly expressed in macrophages in metastatic SKCM and associated with an active tumor immune environment and a favorable prognosis through integrated analysis of single-cell and bulk RNA-seq datasets. High CEBPB expression is significantly associated with active inflammation and immune response pathways in both macrophages and bulk SKCM tumor tissues. A signature based on CEBPB-associated genes that are specifically expressed in macrophages could robustly and prognostically separate different metastatic SKCM patients. In addition, the associations between the metastatic SKCM tumor signature and microenvironment with respect to T-cell recruitment and state, inflammation response, angiogenesis, and so on were also determined. In conclusion, we present here the first report on CEBPB in tumor immune environment and prognosis regulation in metastatic SKCM and construct a reliable signature, which should provide a useful biomarker for stratification of the patient’s prognosis and therapeutic selection. |
| first_indexed | 2024-04-11T19:47:22Z |
| format | Article |
| id | doaj.art-ab4c87b064af471897e3d394313c6a2f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T19:47:22Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ab4c87b064af471897e3d394313c6a2f2022-12-22T04:06:27ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-10-011310.3389/fimmu.2022.991797991797CEBPB is associated with active tumor immune environment and favorable prognosis of metastatic skin cutaneous melanomaJingrun Yang0Jingrun Yang1Yang Xu2Kuixia Xie3Ling Gao4Wenying Zhong5Xinhua Liu6Xinhua Liu7Department of General Surgery, The First Medical Center of Chinese People’s Liberation Army (PLA) General Hospital, Beijing, ChinaKey Laboratory of Bio-inspired Materials and Interfacial Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, ChinaDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, ChinaDepartment of Dermatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, ChinaDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, ChinaDepartment of Dermatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, ChinaDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, ChinaKey Laboratory of Aging and Cancer Biology of Zhejiang Province, Hangzhou Normal University, Hangzhou, ChinaMetastatic skin cutaneous melanoma (SKCM) is a common malignancy that accounts for low morbidity but high mortality of skin cancer. SKCM is characterized by high lymphocytic infiltration, whereas the states of infiltrated cells are variable in patients leading to a heterogeneous prognosis and hindering appropriate clinical decisions. It is therefore urgent to identify markers associated with lymphocytic infiltration, cellular conditions, and the prognosis of SKCM. In this study, we report that CEBPB, a transcriptional factor, is mainly expressed in macrophages in metastatic SKCM and associated with an active tumor immune environment and a favorable prognosis through integrated analysis of single-cell and bulk RNA-seq datasets. High CEBPB expression is significantly associated with active inflammation and immune response pathways in both macrophages and bulk SKCM tumor tissues. A signature based on CEBPB-associated genes that are specifically expressed in macrophages could robustly and prognostically separate different metastatic SKCM patients. In addition, the associations between the metastatic SKCM tumor signature and microenvironment with respect to T-cell recruitment and state, inflammation response, angiogenesis, and so on were also determined. In conclusion, we present here the first report on CEBPB in tumor immune environment and prognosis regulation in metastatic SKCM and construct a reliable signature, which should provide a useful biomarker for stratification of the patient’s prognosis and therapeutic selection.https://www.frontiersin.org/articles/10.3389/fimmu.2022.991797/fullCEBPbSKCMtumor immune microenvironmentsingle cell RNAseqimmune subtype |
| spellingShingle | Jingrun Yang Jingrun Yang Yang Xu Kuixia Xie Ling Gao Wenying Zhong Xinhua Liu Xinhua Liu CEBPB is associated with active tumor immune environment and favorable prognosis of metastatic skin cutaneous melanoma Frontiers in Immunology CEBPb SKCM tumor immune microenvironment single cell RNAseq immune subtype |
| title | CEBPB is associated with active tumor immune environment and favorable prognosis of metastatic skin cutaneous melanoma |
| title_full | CEBPB is associated with active tumor immune environment and favorable prognosis of metastatic skin cutaneous melanoma |
| title_fullStr | CEBPB is associated with active tumor immune environment and favorable prognosis of metastatic skin cutaneous melanoma |
| title_full_unstemmed | CEBPB is associated with active tumor immune environment and favorable prognosis of metastatic skin cutaneous melanoma |
| title_short | CEBPB is associated with active tumor immune environment and favorable prognosis of metastatic skin cutaneous melanoma |
| title_sort | cebpb is associated with active tumor immune environment and favorable prognosis of metastatic skin cutaneous melanoma |
| topic | CEBPb SKCM tumor immune microenvironment single cell RNAseq immune subtype |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.991797/full |
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