Chronic kidney disease and bleeding in patients under low molecular weight heparin prophylaxis
Introduction: The safety of low molecular weight heparin (LMWH) prophylaxis in patients with impaired kidney function remains undefined. Objective: To establish if the reduction of the glomerular filtration rate (GFR) is associated with the development of bleeding under LMWH prophylaxis. Materials a...
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| Format: | Article |
| Language: | English |
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Universidad Nacional de Colombia
2017-10-01
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| Series: | Revista de la Facultad de Medicina |
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| Online Access: | https://revistas.unal.edu.co/index.php/revfacmed/article/view/59769 |
| _version_ | 1818281893401985024 |
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| author | Carmelo José Espinosa-Almanza Hernando Gaitán-Duarte |
| author_facet | Carmelo José Espinosa-Almanza Hernando Gaitán-Duarte |
| author_sort | Carmelo José Espinosa-Almanza |
| collection | DOAJ |
| description | Introduction: The safety of low molecular weight heparin (LMWH) prophylaxis in patients with impaired kidney function remains undefined.
Objective: To establish if the reduction of the glomerular filtration rate (GFR) is associated with the development of bleeding under LMWH prophylaxis.
Materials and methods: A cohort of non-surgical patients with LMWH prophylaxis was constructed in order to conduct a case-control study. Monitoring allowed to find bleeding cases, while four controls were chosen from the population at risk at the time of bleeding onset.
Results: Out of 716 monitored patients, 51 presented with bleeding, with an incidence of 3 cases per 100 patients per day of treatment; 39% of the cases presented with major bleeding and 204 controls were chosen. The multivariate analysis showed no relationship between bleeding and abnormal renal function due to GFR reduction. However, only 3.5% of patients had GFR <30ml/min. The final adjusted odds ratio (OR) was 1.27 and the 95% confidence interval (CI) was 0.60-2.68.
Conclusion: No correlation was found between the reduction of mild to moderate GFR and the development of bleeding under LMWH prophylaxis. |
| first_indexed | 2024-12-13T00:12:21Z |
| format | Article |
| id | doaj.art-ab502ca403ec425bbd325d423d182837 |
| institution | Directory Open Access Journal |
| issn | 0120-0011 2357-3848 |
| language | English |
| last_indexed | 2024-12-13T00:12:21Z |
| publishDate | 2017-10-01 |
| publisher | Universidad Nacional de Colombia |
| record_format | Article |
| series | Revista de la Facultad de Medicina |
| spelling | doaj.art-ab502ca403ec425bbd325d423d1828372022-12-22T00:05:55ZengUniversidad Nacional de ColombiaRevista de la Facultad de Medicina0120-00112357-38482017-10-0165462763110.15446/revfacmed.v65n4.5976947287Chronic kidney disease and bleeding in patients under low molecular weight heparin prophylaxisCarmelo José Espinosa-Almanza0Hernando Gaitán-Duarte1Universidad Nacional de Colombia - Sede Bogotá - Facultad de Medicina - Instituto de Investigaciones Clínicas - Bogotá D.C. - Colombia. Hospital Universitario Clínica San Rafael - Departamento de Medicina Interna - Bogotá D.C. - Colombia.Universidad Nacional de Colombia - Sede Bogotá - Facultad de Medicina - Instituto de Investigaciones Clínicas - Bogotá D.C. - Colombia.Introduction: The safety of low molecular weight heparin (LMWH) prophylaxis in patients with impaired kidney function remains undefined. Objective: To establish if the reduction of the glomerular filtration rate (GFR) is associated with the development of bleeding under LMWH prophylaxis. Materials and methods: A cohort of non-surgical patients with LMWH prophylaxis was constructed in order to conduct a case-control study. Monitoring allowed to find bleeding cases, while four controls were chosen from the population at risk at the time of bleeding onset. Results: Out of 716 monitored patients, 51 presented with bleeding, with an incidence of 3 cases per 100 patients per day of treatment; 39% of the cases presented with major bleeding and 204 controls were chosen. The multivariate analysis showed no relationship between bleeding and abnormal renal function due to GFR reduction. However, only 3.5% of patients had GFR <30ml/min. The final adjusted odds ratio (OR) was 1.27 and the 95% confidence interval (CI) was 0.60-2.68. Conclusion: No correlation was found between the reduction of mild to moderate GFR and the development of bleeding under LMWH prophylaxis.https://revistas.unal.edu.co/index.php/revfacmed/article/view/59769Trombosis de la venaEnoxaparinaEmbolia pulmonarInsuficiencia renal crónica |
| spellingShingle | Carmelo José Espinosa-Almanza Hernando Gaitán-Duarte Chronic kidney disease and bleeding in patients under low molecular weight heparin prophylaxis Revista de la Facultad de Medicina Trombosis de la vena Enoxaparina Embolia pulmonar Insuficiencia renal crónica |
| title | Chronic kidney disease and bleeding in patients under low molecular weight heparin prophylaxis |
| title_full | Chronic kidney disease and bleeding in patients under low molecular weight heparin prophylaxis |
| title_fullStr | Chronic kidney disease and bleeding in patients under low molecular weight heparin prophylaxis |
| title_full_unstemmed | Chronic kidney disease and bleeding in patients under low molecular weight heparin prophylaxis |
| title_short | Chronic kidney disease and bleeding in patients under low molecular weight heparin prophylaxis |
| title_sort | chronic kidney disease and bleeding in patients under low molecular weight heparin prophylaxis |
| topic | Trombosis de la vena Enoxaparina Embolia pulmonar Insuficiencia renal crónica |
| url | https://revistas.unal.edu.co/index.php/revfacmed/article/view/59769 |
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