Hyperreflective Material in Optical Coherence Tomography Images of Eyes with Myopic Choroidal Neovascularization May Affect the Visual Outcome
The visual outcome of myopic choroidal neovascularization (CNV) after anti-vascular endothelial growth factor (anti-VEGF) therapy varies among individuals. We retrospectively analyzed the data of 24 eyes (24 patients) with treatment-naïve myopic CNV who underwent anti-VEGF monotherapy following a pr...
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MDPI AG
2020-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/8/2394 |
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| author | Yasuaki Mushiga Sakiko Minami Atsuro Uchida Norihiro Nagai Misa Suzuki Toshihide Kurihara Hideki Sonobe Norimitsu Ban Kazuhiro Watanabe Hajime Shinoda Kazuo Tsubota Yoko Ozawa |
| author_facet | Yasuaki Mushiga Sakiko Minami Atsuro Uchida Norihiro Nagai Misa Suzuki Toshihide Kurihara Hideki Sonobe Norimitsu Ban Kazuhiro Watanabe Hajime Shinoda Kazuo Tsubota Yoko Ozawa |
| author_sort | Yasuaki Mushiga |
| collection | DOAJ |
| description | The visual outcome of myopic choroidal neovascularization (CNV) after anti-vascular endothelial growth factor (anti-VEGF) therapy varies among individuals. We retrospectively analyzed the data of 24 eyes (24 patients) with treatment-naïve myopic CNV who underwent anti-VEGF monotherapy following a pro-re-nata regimen at the Division of Medical Retina Clinic, Department of Ophthalmology, Keio University Hospital between May 2014 and December 2017. The mean age was 70.6 ± 2.1 years, and 16 (66.7%) patients were female. Overall, the mean best-corrected visual acuity (BCVA) improved (<i>p</i> = 0.034), and the mean height of the hyperreflective material (HRM), involving the CNV lesion recorded by optical coherence tomography, decreased (<i>p</i> < 0.01) 12 months after the initial treatment. Fifteen eyes (62.5%) achieved a BCVA of better than 0.10 in LogMAR at 12 months; they had a better BCVA (<i>p</i> = 0.015) and lower HRM intensity (<i>p</i> = 0.033) at baseline than the others. Remarkably, the BCVA improved (<i>p</i> < 0.05) and the HRM height (<i>p</i> < 0.01) decreased only in eyes with a final BCVA better than 0.10 as early as 1 month after the initial treatment, which was still present at 12 months. The HRM height and intensity, not only the BCVA, would be valuable in evaluating the prognosis of myopic CNV after anti-VEGF therapy, although further study is required. |
| first_indexed | 2024-03-10T18:11:21Z |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T18:11:21Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-ab512e4881144abc8ebbbf171eba51a82023-11-20T08:05:11ZengMDPI AGJournal of Clinical Medicine2077-03832020-07-0198239410.3390/jcm9082394Hyperreflective Material in Optical Coherence Tomography Images of Eyes with Myopic Choroidal Neovascularization May Affect the Visual OutcomeYasuaki Mushiga0Sakiko Minami1Atsuro Uchida2Norihiro Nagai3Misa Suzuki4Toshihide Kurihara5Hideki Sonobe6Norimitsu Ban7Kazuhiro Watanabe8Hajime Shinoda9Kazuo Tsubota10Yoko Ozawa11Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanThe visual outcome of myopic choroidal neovascularization (CNV) after anti-vascular endothelial growth factor (anti-VEGF) therapy varies among individuals. We retrospectively analyzed the data of 24 eyes (24 patients) with treatment-naïve myopic CNV who underwent anti-VEGF monotherapy following a pro-re-nata regimen at the Division of Medical Retina Clinic, Department of Ophthalmology, Keio University Hospital between May 2014 and December 2017. The mean age was 70.6 ± 2.1 years, and 16 (66.7%) patients were female. Overall, the mean best-corrected visual acuity (BCVA) improved (<i>p</i> = 0.034), and the mean height of the hyperreflective material (HRM), involving the CNV lesion recorded by optical coherence tomography, decreased (<i>p</i> < 0.01) 12 months after the initial treatment. Fifteen eyes (62.5%) achieved a BCVA of better than 0.10 in LogMAR at 12 months; they had a better BCVA (<i>p</i> = 0.015) and lower HRM intensity (<i>p</i> = 0.033) at baseline than the others. Remarkably, the BCVA improved (<i>p</i> < 0.05) and the HRM height (<i>p</i> < 0.01) decreased only in eyes with a final BCVA better than 0.10 as early as 1 month after the initial treatment, which was still present at 12 months. The HRM height and intensity, not only the BCVA, would be valuable in evaluating the prognosis of myopic CNV after anti-VEGF therapy, although further study is required.https://www.mdpi.com/2077-0383/9/8/2394high myopiachoroidal neovascularizationretinavisual acuityOCT |
| spellingShingle | Yasuaki Mushiga Sakiko Minami Atsuro Uchida Norihiro Nagai Misa Suzuki Toshihide Kurihara Hideki Sonobe Norimitsu Ban Kazuhiro Watanabe Hajime Shinoda Kazuo Tsubota Yoko Ozawa Hyperreflective Material in Optical Coherence Tomography Images of Eyes with Myopic Choroidal Neovascularization May Affect the Visual Outcome Journal of Clinical Medicine high myopia choroidal neovascularization retina visual acuity OCT |
| title | Hyperreflective Material in Optical Coherence Tomography Images of Eyes with Myopic Choroidal Neovascularization May Affect the Visual Outcome |
| title_full | Hyperreflective Material in Optical Coherence Tomography Images of Eyes with Myopic Choroidal Neovascularization May Affect the Visual Outcome |
| title_fullStr | Hyperreflective Material in Optical Coherence Tomography Images of Eyes with Myopic Choroidal Neovascularization May Affect the Visual Outcome |
| title_full_unstemmed | Hyperreflective Material in Optical Coherence Tomography Images of Eyes with Myopic Choroidal Neovascularization May Affect the Visual Outcome |
| title_short | Hyperreflective Material in Optical Coherence Tomography Images of Eyes with Myopic Choroidal Neovascularization May Affect the Visual Outcome |
| title_sort | hyperreflective material in optical coherence tomography images of eyes with myopic choroidal neovascularization may affect the visual outcome |
| topic | high myopia choroidal neovascularization retina visual acuity OCT |
| url | https://www.mdpi.com/2077-0383/9/8/2394 |
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