Investigation into the anti‐inflammatory properties of metformin in intervertebral disc cells

Investigation into the anti‐inflammatory properties of metformin in intervertebral disc cells

Abstract Introduction Intervertebral disc degeneration (IDD) is closely related to heightened inflammation in the annulus fibrosis (AF) and nucleus pulposus (NP) cells in the intervertebral disc. An imbalanced matrix homeostasis has been shown to contribute to disc degeneration and associated discog...

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Bibliographic Details
Main Authors: Rahul Ramanathan, Ayesha Firdous, Qing Dong, Dong Wang, Joon Lee, Nam Vo, Gwendolyn Sowa
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:JOR Spine
Subjects:
AMPK pathway
anti‐inflammatory
anti‐inflammatory therapy
biomechanical profile of intervertebral disc
disc aging
disc mechanics
Online Access:https://doi.org/10.1002/jsp2.1197

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