Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma
Venetoclax monotherapy is effective in 40% of t(11:14) positive multiple myeloma (MM). Here, the authors show that electron transport chain complex I (CI) and complex II (CII) activity predict MM sensitivity to venetoclax, and inhibition of CI with IACS-010759 or CII with TTFA increase sensitivity.
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15051-z |
| _version_ | 1818422688090161152 |
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| author | Richa Bajpai Aditi Sharma Abhinav Achreja Claudia L. Edgar Changyong Wei Arusha A. Siddiqa Vikas A. Gupta Shannon M. Matulis Samuel K. McBrayer Anjali Mittal Manali Rupji Benjamin G. Barwick Sagar Lonial Ajay K. Nooka Lawrence H. Boise Deepak Nagrath Mala Shanmugam |
| author_facet | Richa Bajpai Aditi Sharma Abhinav Achreja Claudia L. Edgar Changyong Wei Arusha A. Siddiqa Vikas A. Gupta Shannon M. Matulis Samuel K. McBrayer Anjali Mittal Manali Rupji Benjamin G. Barwick Sagar Lonial Ajay K. Nooka Lawrence H. Boise Deepak Nagrath Mala Shanmugam |
| author_sort | Richa Bajpai |
| collection | DOAJ |
| description | Venetoclax monotherapy is effective in 40% of t(11:14) positive multiple myeloma (MM). Here, the authors show that electron transport chain complex I (CI) and complex II (CII) activity predict MM sensitivity to venetoclax, and inhibition of CI with IACS-010759 or CII with TTFA increase sensitivity. |
| first_indexed | 2024-12-14T13:30:13Z |
| format | Article |
| id | doaj.art-ab542c51a366402d8b83cd98c687f243 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:30:13Z |
| publishDate | 2020-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ab542c51a366402d8b83cd98c687f2432022-12-21T22:59:44ZengNature PortfolioNature Communications2041-17232020-03-0111111610.1038/s41467-020-15051-zElectron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myelomaRicha Bajpai0Aditi Sharma1Abhinav Achreja2Claudia L. Edgar3Changyong Wei4Arusha A. Siddiqa5Vikas A. Gupta6Shannon M. Matulis7Samuel K. McBrayer8Anjali Mittal9Manali Rupji10Benjamin G. Barwick11Sagar Lonial12Ajay K. Nooka13Lawrence H. Boise14Deepak Nagrath15Mala Shanmugam16Department of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory UniversityDepartment of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory UniversityDepartment of Biomedical Engineering, University of MichiganDepartment of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory UniversityDepartment of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory UniversityDepartment of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory UniversityDepartment of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory UniversityDepartment of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory UniversityChildren’s Medical Center Research Institute, University of Texas Southwestern Medical CenterBiointerfaces Institute, University of MichiganDepartment of Biostatistics and Bioinformatics Shared Resource, Winship Cancer Institute, Emory UniversityDepartment of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory UniversityDepartment of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory UniversityDepartment of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory UniversityDepartment of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory UniversityDepartment of Biomedical Engineering, University of MichiganDepartment of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory UniversityVenetoclax monotherapy is effective in 40% of t(11:14) positive multiple myeloma (MM). Here, the authors show that electron transport chain complex I (CI) and complex II (CII) activity predict MM sensitivity to venetoclax, and inhibition of CI with IACS-010759 or CII with TTFA increase sensitivity.https://doi.org/10.1038/s41467-020-15051-z |
| spellingShingle | Richa Bajpai Aditi Sharma Abhinav Achreja Claudia L. Edgar Changyong Wei Arusha A. Siddiqa Vikas A. Gupta Shannon M. Matulis Samuel K. McBrayer Anjali Mittal Manali Rupji Benjamin G. Barwick Sagar Lonial Ajay K. Nooka Lawrence H. Boise Deepak Nagrath Mala Shanmugam Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma Nature Communications |
| title | Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma |
| title_full | Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma |
| title_fullStr | Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma |
| title_full_unstemmed | Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma |
| title_short | Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma |
| title_sort | electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma |
| url | https://doi.org/10.1038/s41467-020-15051-z |
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