Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging
Abstract Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied f...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-07-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-93323-4 |
| _version_ | 1818433042778161152 |
|---|---|
| author | Anna C. Bakenecker Anselm von Gladiss Hannes Schwenke André Behrends Thomas Friedrich Kerstin Lüdtke-Buzug Alexander Neumann Joerg Barkhausen Franz Wegner Thorsten M. Buzug |
| author_facet | Anna C. Bakenecker Anselm von Gladiss Hannes Schwenke André Behrends Thomas Friedrich Kerstin Lüdtke-Buzug Alexander Neumann Joerg Barkhausen Franz Wegner Thorsten M. Buzug |
| author_sort | Anna C. Bakenecker |
| collection | DOAJ |
| description | Abstract Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied for a novel coiling procedure. This is shown by navigating the micro-robot through an additively manufactured phantom of a human cerebral aneurysm. The magnetic fields are applied with a magnetic particle imaging (MPI) scanner, which allows for the navigation and tomographic visualization by the same machine. With MPI the actuation process can be visualized with a localization accuracy of 0.68 mm and an angiogram can be acquired both without any radiation exposure. First in-vitro phantom experiments are presented, showing an idea of a robot conducted treatment of cerebral aneurysms. |
| first_indexed | 2024-12-14T16:14:48Z |
| format | Article |
| id | doaj.art-ab54bde244bd4ddb91ffcd4de91f0f13 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T16:14:48Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ab54bde244bd4ddb91ffcd4de91f0f132022-12-21T22:54:56ZengNature PortfolioScientific Reports2045-23222021-07-0111111210.1038/s41598-021-93323-4Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imagingAnna C. Bakenecker0Anselm von Gladiss1Hannes Schwenke2André Behrends3Thomas Friedrich4Kerstin Lüdtke-Buzug5Alexander Neumann6Joerg Barkhausen7Franz Wegner8Thorsten M. Buzug9Institute of Medical Engineering, University of LübeckInstitute of Medical Engineering, University of LübeckDepartment of Neuroradiology, University Hospital Schleswig-HolsteinInstitute of Medical Engineering, University of LübeckInstitute of Medical Engineering, University of LübeckInstitute of Medical Engineering, University of LübeckInstitute of Medical Engineering, University of LübeckDepartment of Radiology and Nuclear Medicine, University of LübeckDepartment of Radiology and Nuclear Medicine, University of LübeckInstitute of Medical Engineering, University of LübeckAbstract Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied for a novel coiling procedure. This is shown by navigating the micro-robot through an additively manufactured phantom of a human cerebral aneurysm. The magnetic fields are applied with a magnetic particle imaging (MPI) scanner, which allows for the navigation and tomographic visualization by the same machine. With MPI the actuation process can be visualized with a localization accuracy of 0.68 mm and an angiogram can be acquired both without any radiation exposure. First in-vitro phantom experiments are presented, showing an idea of a robot conducted treatment of cerebral aneurysms.https://doi.org/10.1038/s41598-021-93323-4 |
| spellingShingle | Anna C. Bakenecker Anselm von Gladiss Hannes Schwenke André Behrends Thomas Friedrich Kerstin Lüdtke-Buzug Alexander Neumann Joerg Barkhausen Franz Wegner Thorsten M. Buzug Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging Scientific Reports |
| title | Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging |
| title_full | Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging |
| title_fullStr | Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging |
| title_full_unstemmed | Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging |
| title_short | Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging |
| title_sort | navigation of a magnetic micro robot through a cerebral aneurysm phantom with magnetic particle imaging |
| url | https://doi.org/10.1038/s41598-021-93323-4 |
| work_keys_str_mv | AT annacbakenecker navigationofamagneticmicrorobotthroughacerebralaneurysmphantomwithmagneticparticleimaging AT anselmvongladiss navigationofamagneticmicrorobotthroughacerebralaneurysmphantomwithmagneticparticleimaging AT hannesschwenke navigationofamagneticmicrorobotthroughacerebralaneurysmphantomwithmagneticparticleimaging AT andrebehrends navigationofamagneticmicrorobotthroughacerebralaneurysmphantomwithmagneticparticleimaging AT thomasfriedrich navigationofamagneticmicrorobotthroughacerebralaneurysmphantomwithmagneticparticleimaging AT kerstinludtkebuzug navigationofamagneticmicrorobotthroughacerebralaneurysmphantomwithmagneticparticleimaging AT alexanderneumann navigationofamagneticmicrorobotthroughacerebralaneurysmphantomwithmagneticparticleimaging AT joergbarkhausen navigationofamagneticmicrorobotthroughacerebralaneurysmphantomwithmagneticparticleimaging AT franzwegner navigationofamagneticmicrorobotthroughacerebralaneurysmphantomwithmagneticparticleimaging AT thorstenmbuzug navigationofamagneticmicrorobotthroughacerebralaneurysmphantomwithmagneticparticleimaging |