Starfruit Leaves as Glucose Absorption Inhibitor in Mice’s Small Intestinal Epithelial Cells
Background: Starfruit (Averrhoa carambola) leaves contain flavone derivatives that exhibit anti-hyperglycemic effects. This study aims to determine the effect of starfruit leaves in reducing glucose absorption in intestinal epithelial cells of mice. Methods: This study was done by performing perfusi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universitas Indonesia
2016-12-01
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| Series: | Makara Journal of Health Research |
| Subjects: | |
| Online Access: | https://scholarhub.ui.ac.id/mjhr/vol20/iss3/2/ |
| _version_ | 1797847311918825472 |
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| author | Rifqi Y. Muhammad Ramdan Panigoro Julius B. Dewanto |
| author_facet | Rifqi Y. Muhammad Ramdan Panigoro Julius B. Dewanto |
| author_sort | Rifqi Y. Muhammad |
| collection | DOAJ |
| description | Background: Starfruit (Averrhoa carambola) leaves contain flavone derivatives that exhibit anti-hyperglycemic effects. This study aims to determine the effect of starfruit leaves in reducing glucose absorption in intestinal epithelial cells of mice. Methods: This study was done by performing perfusion on the small intestines of mice. The mice that were used in this study were divided into four groups. The control group was given glucose solution without infused starfruit leaves whereas, the remaining 3 groups were given 3 mmol (540 mg/dL) glucose solution with infused starfruit leaves of varying concentrations; 200, 400, and 600 mg/kg. Samples were collected at 0, 15th, 30th, 45th, and 60th minute. The sample was tested for glucose levels using spectrophotometry. Results: Test of significance showed a significant difference between the control group and the test group with p < 0.05. Conclusions: Starfruit leaves have a reduction effect towards glucose absorption in the small intestines in Wistar strains where the group using 600 mg/kg of infused starfruit leaves have the most significant effect as compared to other groups. |
| first_indexed | 2024-04-09T18:09:15Z |
| format | Article |
| id | doaj.art-ab566494636b454999fa7be333467e3c |
| institution | Directory Open Access Journal |
| issn | 2356-3664 2356-3656 |
| language | English |
| last_indexed | 2024-04-09T18:09:15Z |
| publishDate | 2016-12-01 |
| publisher | Universitas Indonesia |
| record_format | Article |
| series | Makara Journal of Health Research |
| spelling | doaj.art-ab566494636b454999fa7be333467e3c2023-04-14T03:29:31ZengUniversitas IndonesiaMakara Journal of Health Research2356-36642356-36562016-12-01203697210.7454/msk.v20i3.53563311Starfruit Leaves as Glucose Absorption Inhibitor in Mice’s Small Intestinal Epithelial CellsRifqi Y. Muhammad0Ramdan Panigoro1Julius B. Dewanto2Faculty of Medicine, Universitas Padjadjaran, Sumedang 40363, IndonesiaDepartement of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Padjadjaran, Sumedang 40363, IndonesiaDepartement of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Padjadjaran, Sumedang 40363, IndonesiaBackground: Starfruit (Averrhoa carambola) leaves contain flavone derivatives that exhibit anti-hyperglycemic effects. This study aims to determine the effect of starfruit leaves in reducing glucose absorption in intestinal epithelial cells of mice. Methods: This study was done by performing perfusion on the small intestines of mice. The mice that were used in this study were divided into four groups. The control group was given glucose solution without infused starfruit leaves whereas, the remaining 3 groups were given 3 mmol (540 mg/dL) glucose solution with infused starfruit leaves of varying concentrations; 200, 400, and 600 mg/kg. Samples were collected at 0, 15th, 30th, 45th, and 60th minute. The sample was tested for glucose levels using spectrophotometry. Results: Test of significance showed a significant difference between the control group and the test group with p < 0.05. Conclusions: Starfruit leaves have a reduction effect towards glucose absorption in the small intestines in Wistar strains where the group using 600 mg/kg of infused starfruit leaves have the most significant effect as compared to other groups.https://scholarhub.ui.ac.id/mjhr/vol20/iss3/2/absorptionaverrhoa carambolaglucoseinfusionintestine small |
| spellingShingle | Rifqi Y. Muhammad Ramdan Panigoro Julius B. Dewanto Starfruit Leaves as Glucose Absorption Inhibitor in Mice’s Small Intestinal Epithelial Cells Makara Journal of Health Research absorption averrhoa carambola glucose infusion intestine small |
| title | Starfruit Leaves as Glucose Absorption Inhibitor in Mice’s Small Intestinal Epithelial Cells |
| title_full | Starfruit Leaves as Glucose Absorption Inhibitor in Mice’s Small Intestinal Epithelial Cells |
| title_fullStr | Starfruit Leaves as Glucose Absorption Inhibitor in Mice’s Small Intestinal Epithelial Cells |
| title_full_unstemmed | Starfruit Leaves as Glucose Absorption Inhibitor in Mice’s Small Intestinal Epithelial Cells |
| title_short | Starfruit Leaves as Glucose Absorption Inhibitor in Mice’s Small Intestinal Epithelial Cells |
| title_sort | starfruit leaves as glucose absorption inhibitor in mice s small intestinal epithelial cells |
| topic | absorption averrhoa carambola glucose infusion intestine small |
| url | https://scholarhub.ui.ac.id/mjhr/vol20/iss3/2/ |
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