Primary lung cancer treatable with radical resection after complete remission with pembrolizumab therapy following gemcitabine and carboplatin chemotherapy for multiple metastases of bladder cancer
Introduction We report a patient with the complete remission of multiple metastases and primary bladder lesions of bladder cancer who developed primary lung cancer requiring radical resection. Case presentation A 68‐year‐old man diagnosed with invasive bladder cancer, right hydroureteronephrosis, an...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | IJU Case Reports |
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| Online Access: | https://doi.org/10.1002/iju5.12550 |
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| author | Ryohta Nakamura Go Hasegawa Kazumasa Ohashi Takehisa Hashimoto Yohei Ikeda Noboru Hara Tsutomu Nishiyama |
| author_facet | Ryohta Nakamura Go Hasegawa Kazumasa Ohashi Takehisa Hashimoto Yohei Ikeda Noboru Hara Tsutomu Nishiyama |
| author_sort | Ryohta Nakamura |
| collection | DOAJ |
| description | Introduction We report a patient with the complete remission of multiple metastases and primary bladder lesions of bladder cancer who developed primary lung cancer requiring radical resection. Case presentation A 68‐year‐old man diagnosed with invasive bladder cancer, right hydroureteronephrosis, and multiple metastases were administered six courses of gemcitabine and carboplatin chemotherapy and thereafter has been receiving pembrolizumab therapy. Bladder cancer and multiple metastases decreased in size, whereas a ground‐glass opacity lesion in the lung gradually increased in size. Fluorodeoxyglucose‐positron emission tomography revealed the accumulation of fluorodeoxyglucose in the ground‐glass opacity lesion only. The patient was diagnosed with primary lung cancer and underwent a thoracoscopic lobectomy. Histopathological findings showed ALK‐negative, EGFR L858R mutation‐positive invasive adenocarcinoma with a programmed death‐ligand 1 tumor proportion score of less than 1%. Conclusion This is the first case report of patients with the complete remission of multiple metastases of bladder cancer who developed primary lung cancer requiring radical resection. |
| first_indexed | 2024-04-11T02:17:27Z |
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| id | doaj.art-ab56b1ae05604d328039f277cce51d83 |
| institution | Directory Open Access Journal |
| issn | 2577-171X |
| language | English |
| last_indexed | 2024-04-11T02:17:27Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
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| series | IJU Case Reports |
| spelling | doaj.art-ab56b1ae05604d328039f277cce51d832023-01-03T00:53:57ZengWileyIJU Case Reports2577-171X2023-01-0161858810.1002/iju5.12550Primary lung cancer treatable with radical resection after complete remission with pembrolizumab therapy following gemcitabine and carboplatin chemotherapy for multiple metastases of bladder cancerRyohta Nakamura0Go Hasegawa1Kazumasa Ohashi2Takehisa Hashimoto3Yohei Ikeda4Noboru Hara5Tsutomu Nishiyama6Department of Urology, Uonuma Institute of Community Medicine Niigata University Medical and Dental Hospital Minamiuonuma Niigata JapanDepartment of Pathology, Uonuma Institute of Community Medicine Niigata University Medical and Dental Hospital Minamiuonuma Niigata JapanDepartment of Respiratory Medicine, Uonuma Institute of Community Medicine Niigata University Medical and Dental Hospital Minamiuonuma Niigata JapanDepartment of Respiratory Surgery, Uonuma Institute of Community Medicine Niigata University Medical and Dental Hospital Minamiuonuma Niigata JapanDepartment of Diagnostic Radiology, Uonuma Institute of Community Medicine Niigata University Medical and Dental Hospital Minamiuonuma Niigata JapanDepartment of Urology, Uonuma Institute of Community Medicine Niigata University Medical and Dental Hospital Minamiuonuma Niigata JapanDepartment of Urology, Uonuma Institute of Community Medicine Niigata University Medical and Dental Hospital Minamiuonuma Niigata JapanIntroduction We report a patient with the complete remission of multiple metastases and primary bladder lesions of bladder cancer who developed primary lung cancer requiring radical resection. Case presentation A 68‐year‐old man diagnosed with invasive bladder cancer, right hydroureteronephrosis, and multiple metastases were administered six courses of gemcitabine and carboplatin chemotherapy and thereafter has been receiving pembrolizumab therapy. Bladder cancer and multiple metastases decreased in size, whereas a ground‐glass opacity lesion in the lung gradually increased in size. Fluorodeoxyglucose‐positron emission tomography revealed the accumulation of fluorodeoxyglucose in the ground‐glass opacity lesion only. The patient was diagnosed with primary lung cancer and underwent a thoracoscopic lobectomy. Histopathological findings showed ALK‐negative, EGFR L858R mutation‐positive invasive adenocarcinoma with a programmed death‐ligand 1 tumor proportion score of less than 1%. Conclusion This is the first case report of patients with the complete remission of multiple metastases of bladder cancer who developed primary lung cancer requiring radical resection.https://doi.org/10.1002/iju5.12550advanced bladder cancerpembrolizumab therapy following gemcitabine and carboplatin chemotherapy with complete remissionprimary lung cancer with radical resection |
| spellingShingle | Ryohta Nakamura Go Hasegawa Kazumasa Ohashi Takehisa Hashimoto Yohei Ikeda Noboru Hara Tsutomu Nishiyama Primary lung cancer treatable with radical resection after complete remission with pembrolizumab therapy following gemcitabine and carboplatin chemotherapy for multiple metastases of bladder cancer IJU Case Reports advanced bladder cancer pembrolizumab therapy following gemcitabine and carboplatin chemotherapy with complete remission primary lung cancer with radical resection |
| title | Primary lung cancer treatable with radical resection after complete remission with pembrolizumab therapy following gemcitabine and carboplatin chemotherapy for multiple metastases of bladder cancer |
| title_full | Primary lung cancer treatable with radical resection after complete remission with pembrolizumab therapy following gemcitabine and carboplatin chemotherapy for multiple metastases of bladder cancer |
| title_fullStr | Primary lung cancer treatable with radical resection after complete remission with pembrolizumab therapy following gemcitabine and carboplatin chemotherapy for multiple metastases of bladder cancer |
| title_full_unstemmed | Primary lung cancer treatable with radical resection after complete remission with pembrolizumab therapy following gemcitabine and carboplatin chemotherapy for multiple metastases of bladder cancer |
| title_short | Primary lung cancer treatable with radical resection after complete remission with pembrolizumab therapy following gemcitabine and carboplatin chemotherapy for multiple metastases of bladder cancer |
| title_sort | primary lung cancer treatable with radical resection after complete remission with pembrolizumab therapy following gemcitabine and carboplatin chemotherapy for multiple metastases of bladder cancer |
| topic | advanced bladder cancer pembrolizumab therapy following gemcitabine and carboplatin chemotherapy with complete remission primary lung cancer with radical resection |
| url | https://doi.org/10.1002/iju5.12550 |
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