Enhanced Stability of Dopamine Delivery via Hydrogel with Integrated Graphene
The synthesis of graphene-based materials for drug delivery represents an area of active research, and the use of graphene in drug delivery systems is promising due to its unique properties. Thus, in the present work, we discuss the potential of few-layer graphene in a hydrogel system for dopamine r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/14/12/558 |
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| author | Cristina Mormile Ocsana Opriș Stefano Bellucci Ildiko Lung Irina Kacso Alexandru Turza Matteo La Pietra Cristian Vacacela Gomez Adina Stegarescu Maria-Loredana Soran |
| author_facet | Cristina Mormile Ocsana Opriș Stefano Bellucci Ildiko Lung Irina Kacso Alexandru Turza Matteo La Pietra Cristian Vacacela Gomez Adina Stegarescu Maria-Loredana Soran |
| author_sort | Cristina Mormile |
| collection | DOAJ |
| description | The synthesis of graphene-based materials for drug delivery represents an area of active research, and the use of graphene in drug delivery systems is promising due to its unique properties. Thus, in the present work, we discuss the potential of few-layer graphene in a hydrogel system for dopamine release. The hydrogels are frequently used for these systems for their special physico-chemical properties, which can ensure that the drug is effectively released in time. However, the release from such structures is mostly determined by diffusion alone, and to overcome this restriction, the hydrogel can be “improved” with nanoscale fillers like graphene. The release kinetics of the composite obtained were analyzed to better understand how the use of graphene, instead of the more common graphene oxide (GO) and reduced graphene oxide (rGO), affects the characteristics of the system. Thus, the systems developed in this study consist of three main components: biopolymer, graphene, and dopamine. The hydrogels with graphene were prepared by combining two different solutions, one with polyacrylic acid and agarose and one with graphene prepared by the exfoliation method with microwave irradiation. The drug delivery systems were developed by adding dopamine to the obtained hydrogels. After 24 h of release, the presence of dopamine was observed, demonstrating that the system developed can slow down the drug’s degradation because of the interactions with the graphene nanoplates and the polymer matrix. |
| first_indexed | 2024-03-08T20:39:06Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-08T20:39:06Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-ab57463c3a2e472db8693e473574afb92023-12-22T14:17:59ZengMDPI AGJournal of Functional Biomaterials2079-49832023-11-01141255810.3390/jfb14120558Enhanced Stability of Dopamine Delivery via Hydrogel with Integrated GrapheneCristina Mormile0Ocsana Opriș1Stefano Bellucci2Ildiko Lung3Irina Kacso4Alexandru Turza5Matteo La Pietra6Cristian Vacacela Gomez7Adina Stegarescu8Maria-Loredana Soran9National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat, 400293 Cluj-Napoca, RomaniaINFN—National Laboratories of Frascati, Via Enrico Fermi 54, 00044 Frascati, ItalyNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat, 400293 Cluj-Napoca, RomaniaINFN—National Laboratories of Frascati, Via Enrico Fermi 54, 00044 Frascati, ItalyINFN—National Laboratories of Frascati, Via Enrico Fermi 54, 00044 Frascati, ItalyNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat, 400293 Cluj-Napoca, RomaniaThe synthesis of graphene-based materials for drug delivery represents an area of active research, and the use of graphene in drug delivery systems is promising due to its unique properties. Thus, in the present work, we discuss the potential of few-layer graphene in a hydrogel system for dopamine release. The hydrogels are frequently used for these systems for their special physico-chemical properties, which can ensure that the drug is effectively released in time. However, the release from such structures is mostly determined by diffusion alone, and to overcome this restriction, the hydrogel can be “improved” with nanoscale fillers like graphene. The release kinetics of the composite obtained were analyzed to better understand how the use of graphene, instead of the more common graphene oxide (GO) and reduced graphene oxide (rGO), affects the characteristics of the system. Thus, the systems developed in this study consist of three main components: biopolymer, graphene, and dopamine. The hydrogels with graphene were prepared by combining two different solutions, one with polyacrylic acid and agarose and one with graphene prepared by the exfoliation method with microwave irradiation. The drug delivery systems were developed by adding dopamine to the obtained hydrogels. After 24 h of release, the presence of dopamine was observed, demonstrating that the system developed can slow down the drug’s degradation because of the interactions with the graphene nanoplates and the polymer matrix.https://www.mdpi.com/2079-4983/14/12/558hydrogelsgraphenedrug deliverydopamine |
| spellingShingle | Cristina Mormile Ocsana Opriș Stefano Bellucci Ildiko Lung Irina Kacso Alexandru Turza Matteo La Pietra Cristian Vacacela Gomez Adina Stegarescu Maria-Loredana Soran Enhanced Stability of Dopamine Delivery via Hydrogel with Integrated Graphene Journal of Functional Biomaterials hydrogels graphene drug delivery dopamine |
| title | Enhanced Stability of Dopamine Delivery via Hydrogel with Integrated Graphene |
| title_full | Enhanced Stability of Dopamine Delivery via Hydrogel with Integrated Graphene |
| title_fullStr | Enhanced Stability of Dopamine Delivery via Hydrogel with Integrated Graphene |
| title_full_unstemmed | Enhanced Stability of Dopamine Delivery via Hydrogel with Integrated Graphene |
| title_short | Enhanced Stability of Dopamine Delivery via Hydrogel with Integrated Graphene |
| title_sort | enhanced stability of dopamine delivery via hydrogel with integrated graphene |
| topic | hydrogels graphene drug delivery dopamine |
| url | https://www.mdpi.com/2079-4983/14/12/558 |
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