Role of the portal system in liver regeneration: From molecular mechanisms to clinical management
The liver has a strong regenerative capacity that ensures patient recovery after hepatectomy and liver transplantation. The portal system plays a crucial role in the dual blood supply to the liver, making it a significant factor in hepatic function. Several surgical strategies, such as portal vein l...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2024-03-01
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| Series: | Liver Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2542568424000023 |
| _version_ | 1797237985523007488 |
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| author | Hanzhi Xu Xun Qiu Zhoucheng Wang Kai Wang Yawen Tan Fengqiang Gao Marcos Vinicius Perini Xiao Xu |
| author_facet | Hanzhi Xu Xun Qiu Zhoucheng Wang Kai Wang Yawen Tan Fengqiang Gao Marcos Vinicius Perini Xiao Xu |
| author_sort | Hanzhi Xu |
| collection | DOAJ |
| description | The liver has a strong regenerative capacity that ensures patient recovery after hepatectomy and liver transplantation. The portal system plays a crucial role in the dual blood supply to the liver, making it a significant factor in hepatic function. Several surgical strategies, such as portal vein ligation, associating liver partition and portal vein ligation for staged hepatectomy, and dual vein embolization, have highlighted the portal system's importance in liver regeneration. Following hepatectomy or liver transplantation, the hemodynamic properties of the portal system change dramatically, triggering regeneration via shear stress and the induction of hypoxia. However, excessive portal hyperperfusion can harm the liver and negatively affect patient outcomes. Furthermore, as the importance of the gut–liver axis has gradually been revealed, the effect of metabolites and cytokines from gut microbes carried by portal blood on liver regeneration has been acknowledged. From these perspectives, this review outlines the molecular mechanisms of the portal system's role in liver regeneration and summarizes therapeutic strategies based on the portal system intervention to promote liver regeneration. |
| first_indexed | 2024-04-24T17:28:27Z |
| format | Article |
| id | doaj.art-ab57505dd496404caf79e6ff77324798 |
| institution | Directory Open Access Journal |
| issn | 2542-5684 |
| language | English |
| last_indexed | 2024-04-24T17:28:27Z |
| publishDate | 2024-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Liver Research |
| spelling | doaj.art-ab57505dd496404caf79e6ff773247982024-03-28T06:38:35ZengKeAi Communications Co., Ltd.Liver Research2542-56842024-03-0181110Role of the portal system in liver regeneration: From molecular mechanisms to clinical managementHanzhi Xu0Xun Qiu1Zhoucheng Wang2Kai Wang3Yawen Tan4Fengqiang Gao5Marcos Vinicius Perini6Xiao Xu7Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaZhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaZhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaZhejiang University School of Medicine, Hangzhou, Zhejiang, China; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, Zhejiang, China; Corresponding authors. Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaZhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Surgery, University of Melbourne, Austin Health, Heidelberg, Victoria, AustraliaZhejiang University School of Medicine, Hangzhou, Zhejiang, China; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, Zhejiang, China; Corresponding authors. Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.The liver has a strong regenerative capacity that ensures patient recovery after hepatectomy and liver transplantation. The portal system plays a crucial role in the dual blood supply to the liver, making it a significant factor in hepatic function. Several surgical strategies, such as portal vein ligation, associating liver partition and portal vein ligation for staged hepatectomy, and dual vein embolization, have highlighted the portal system's importance in liver regeneration. Following hepatectomy or liver transplantation, the hemodynamic properties of the portal system change dramatically, triggering regeneration via shear stress and the induction of hypoxia. However, excessive portal hyperperfusion can harm the liver and negatively affect patient outcomes. Furthermore, as the importance of the gut–liver axis has gradually been revealed, the effect of metabolites and cytokines from gut microbes carried by portal blood on liver regeneration has been acknowledged. From these perspectives, this review outlines the molecular mechanisms of the portal system's role in liver regeneration and summarizes therapeutic strategies based on the portal system intervention to promote liver regeneration.http://www.sciencedirect.com/science/article/pii/S2542568424000023Portal systemLiver regenerationHemodynamic propertiesGut microbiotaTherapeutic strategies |
| spellingShingle | Hanzhi Xu Xun Qiu Zhoucheng Wang Kai Wang Yawen Tan Fengqiang Gao Marcos Vinicius Perini Xiao Xu Role of the portal system in liver regeneration: From molecular mechanisms to clinical management Liver Research Portal system Liver regeneration Hemodynamic properties Gut microbiota Therapeutic strategies |
| title | Role of the portal system in liver regeneration: From molecular mechanisms to clinical management |
| title_full | Role of the portal system in liver regeneration: From molecular mechanisms to clinical management |
| title_fullStr | Role of the portal system in liver regeneration: From molecular mechanisms to clinical management |
| title_full_unstemmed | Role of the portal system in liver regeneration: From molecular mechanisms to clinical management |
| title_short | Role of the portal system in liver regeneration: From molecular mechanisms to clinical management |
| title_sort | role of the portal system in liver regeneration from molecular mechanisms to clinical management |
| topic | Portal system Liver regeneration Hemodynamic properties Gut microbiota Therapeutic strategies |
| url | http://www.sciencedirect.com/science/article/pii/S2542568424000023 |
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