Impact of LINE-1 hypomethylation on the clinicopathological and molecular features of colorectal cancer patients.

Impact of LINE-1 hypomethylation on the clinicopathological and molecular features of colorectal cancer patients.

Recent studies suggest that aberrant DNA methylation might occur early and commonly in colorectal tumorigenesis. In 111 normal subjects, the mean LINE-1 methylation level of peripheral blood was 81.0 ± 5.7%. Of 143 colorectal cancer (CRC) patients, the mean level of LINE-1 methylation was 60.5 ± 12....

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Main Authors: Tai-Chuan Kuan, Pei-Ching Lin, Shung-Haur Yang, Chun-Chi Lin, Yuan-Tzu Lan, Hung-Hsin Lin, Wen-Yi Liang, Wei-Shone Chen, Jen-Kou Lin, Jeng-Kai Jiang, Shih-Ching Chang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5993106?pdf=render

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