Factors Associated with Spontaneous Clearance of Recently Acquired Hepatitis C Virus among HIV-Positive Men in Brazil
Introduction: The objective of the present study was to describe the clinical and epidemiological aspects of recently acquired hepatitis C virus (HCV) infection and the frequency of its spontaneous clearance in a people living with the human immunodeficiency virus (PLWH) cohort. Methods: We reviewed...
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MDPI AG
2023-01-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/2/314 |
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| author | Rosario Quiroga Ferrufino Camila Rodrigues Gerusa Maria Figueiredo Daniel Gleison Silvia Yapura Maria Laura Mariano de Matos Steven S. Witkin Maria Cássia Mendes-Correa |
| author_facet | Rosario Quiroga Ferrufino Camila Rodrigues Gerusa Maria Figueiredo Daniel Gleison Silvia Yapura Maria Laura Mariano de Matos Steven S. Witkin Maria Cássia Mendes-Correa |
| author_sort | Rosario Quiroga Ferrufino |
| collection | DOAJ |
| description | Introduction: The objective of the present study was to describe the clinical and epidemiological aspects of recently acquired hepatitis C virus (HCV) infection and the frequency of its spontaneous clearance in a people living with the human immunodeficiency virus (PLWH) cohort. Methods: We reviewed the medical records from all PLWH at the human immunodeficiency virus (HIV) outpatient reference clinic affiliated with the University of São Paulo, Brazil, and identified, by immunoassays and RNA-PCR individuals who acquired HCV infection between January 2015 and December 2017. The factors associated with subsequent spontaneous clearance of the infection in this group were identified and analyzed. Results: Among 3143 PLWH individuals, 362 (11.5%) were coinfected with HCV. Forty-eight (13.2%) of these subjects first became HCV-positive between January 2015 and December 2017. Spontaneous HCV clearance was documented in 23 individuals (47.9%). The majority of this latter group were male (83.3%), and the median age was 31 years (23–39). The main risk group for HCV acquisition was men who had sex with men (MSM) (89.5%). In a multivariate analysis, only an elevated CD4+ T lymphocyte count at the time of seroconversion was found to be associated with subsequent HCV clearance (<i>p</i> = 0.025). Conclusions: In HIV-infected individuals in Sao Paulo, Brazil, most cases of recent HCV transmission were by sexual exposure. In PLWH, particularly in MSM, the individual’s CD4+ T lymphocyte count is a determinant of whether an acquired HCV infection will be prolonged or will spontaneously clear. |
| first_indexed | 2024-03-11T08:01:00Z |
| format | Article |
| id | doaj.art-ab5d6750c726409d8e44a2d9a7cc745b |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T08:01:00Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-ab5d6750c726409d8e44a2d9a7cc745b2023-11-16T23:47:21ZengMDPI AGViruses1999-49152023-01-0115231410.3390/v15020314Factors Associated with Spontaneous Clearance of Recently Acquired Hepatitis C Virus among HIV-Positive Men in BrazilRosario Quiroga Ferrufino0Camila Rodrigues1Gerusa Maria Figueiredo2Daniel Gleison3Silvia Yapura4Maria Laura Mariano de Matos5Steven S. Witkin6Maria Cássia Mendes-Correa7Departamento de Molestias Infecciosas e Parasitarias, Aculdade de Medicina, Universidade de São Paulo, Av. Dr. Enéas Carvalho de Aguiar, n. 470, São Paulo 05403-000, BrazilHospital das Clínicas, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo 05403-010, BrazilInstituto de Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-000, BrazilHospital das Clínicas, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo 05403-010, BrazilHospital das Clínicas, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo 05403-010, BrazilDepartamento de Molestias Infecciosas e Parasitarias, Aculdade de Medicina, Universidade de São Paulo, Av. Dr. Enéas Carvalho de Aguiar, n. 470, São Paulo 05403-000, BrazilDepartamento de Molestias Infecciosas e Parasitarias, Aculdade de Medicina, Universidade de São Paulo, Av. Dr. Enéas Carvalho de Aguiar, n. 470, São Paulo 05403-000, BrazilDepartamento de Molestias Infecciosas e Parasitarias, Aculdade de Medicina, Universidade de São Paulo, Av. Dr. Enéas Carvalho de Aguiar, n. 470, São Paulo 05403-000, BrazilIntroduction: The objective of the present study was to describe the clinical and epidemiological aspects of recently acquired hepatitis C virus (HCV) infection and the frequency of its spontaneous clearance in a people living with the human immunodeficiency virus (PLWH) cohort. Methods: We reviewed the medical records from all PLWH at the human immunodeficiency virus (HIV) outpatient reference clinic affiliated with the University of São Paulo, Brazil, and identified, by immunoassays and RNA-PCR individuals who acquired HCV infection between January 2015 and December 2017. The factors associated with subsequent spontaneous clearance of the infection in this group were identified and analyzed. Results: Among 3143 PLWH individuals, 362 (11.5%) were coinfected with HCV. Forty-eight (13.2%) of these subjects first became HCV-positive between January 2015 and December 2017. Spontaneous HCV clearance was documented in 23 individuals (47.9%). The majority of this latter group were male (83.3%), and the median age was 31 years (23–39). The main risk group for HCV acquisition was men who had sex with men (MSM) (89.5%). In a multivariate analysis, only an elevated CD4+ T lymphocyte count at the time of seroconversion was found to be associated with subsequent HCV clearance (<i>p</i> = 0.025). Conclusions: In HIV-infected individuals in Sao Paulo, Brazil, most cases of recent HCV transmission were by sexual exposure. In PLWH, particularly in MSM, the individual’s CD4+ T lymphocyte count is a determinant of whether an acquired HCV infection will be prolonged or will spontaneously clear.https://www.mdpi.com/1999-4915/15/2/314HIV/coinfectionrecently acquired hepatitis C infectionHIVspontaneous clearanceimmunityacute HCV |
| spellingShingle | Rosario Quiroga Ferrufino Camila Rodrigues Gerusa Maria Figueiredo Daniel Gleison Silvia Yapura Maria Laura Mariano de Matos Steven S. Witkin Maria Cássia Mendes-Correa Factors Associated with Spontaneous Clearance of Recently Acquired Hepatitis C Virus among HIV-Positive Men in Brazil Viruses HIV/coinfection recently acquired hepatitis C infection HIV spontaneous clearance immunity acute HCV |
| title | Factors Associated with Spontaneous Clearance of Recently Acquired Hepatitis C Virus among HIV-Positive Men in Brazil |
| title_full | Factors Associated with Spontaneous Clearance of Recently Acquired Hepatitis C Virus among HIV-Positive Men in Brazil |
| title_fullStr | Factors Associated with Spontaneous Clearance of Recently Acquired Hepatitis C Virus among HIV-Positive Men in Brazil |
| title_full_unstemmed | Factors Associated with Spontaneous Clearance of Recently Acquired Hepatitis C Virus among HIV-Positive Men in Brazil |
| title_short | Factors Associated with Spontaneous Clearance of Recently Acquired Hepatitis C Virus among HIV-Positive Men in Brazil |
| title_sort | factors associated with spontaneous clearance of recently acquired hepatitis c virus among hiv positive men in brazil |
| topic | HIV/coinfection recently acquired hepatitis C infection HIV spontaneous clearance immunity acute HCV |
| url | https://www.mdpi.com/1999-4915/15/2/314 |
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