A case of ruptured sinus of Valsalva aneurysm and reversible flow-induced pulmonary hypertension
Pulmonary hypertension (PH) in adults with congenital heart disease (CHD) and significant systemic-to-pulmonary shunting is a significant cause of morbidity and mortality. Its pathophysiology is incompletely understood, but involves a flow-induced pulmonary arteriopathy characterized by endothelial...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-03-01
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| Series: | Pulmonary Circulation |
| Online Access: | https://doi.org/10.1177/2045894018760656 |
| _version_ | 1811228065592770560 |
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| author | Basil Al-Sabeq Sabe De Ryan Davey |
| author_facet | Basil Al-Sabeq Sabe De Ryan Davey |
| author_sort | Basil Al-Sabeq |
| collection | DOAJ |
| description | Pulmonary hypertension (PH) in adults with congenital heart disease (CHD) and significant systemic-to-pulmonary shunting is a significant cause of morbidity and mortality. Its pathophysiology is incompletely understood, but involves a flow-induced pulmonary arteriopathy characterized by endothelial cell dysfunction and vascular remodeling that alters pulmonary arterial vasoreactivity. There is a paucity of literature linking PH with left-to-right shunting due to ruptured sinus of Valsalva aneurysms (SOVA). We present a unique case of reversible, flow-associated PH due to a ruptured congenital right SOVA fistulizing into the right atrium (RA), with emphasis on non-invasive and invasive assessment of pulmonary hemodynamics before and after surgical intervention. |
| first_indexed | 2024-04-12T09:53:35Z |
| format | Article |
| id | doaj.art-ab5ddf8729d94168a44df6c645593974 |
| institution | Directory Open Access Journal |
| issn | 2045-8940 |
| language | English |
| last_indexed | 2024-04-12T09:53:35Z |
| publishDate | 2018-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Circulation |
| spelling | doaj.art-ab5ddf8729d94168a44df6c6455939742022-12-22T03:37:47ZengWileyPulmonary Circulation2045-89402018-03-01810.1177/2045894018760656A case of ruptured sinus of Valsalva aneurysm and reversible flow-induced pulmonary hypertensionBasil Al-SabeqSabe DeRyan DaveyPulmonary hypertension (PH) in adults with congenital heart disease (CHD) and significant systemic-to-pulmonary shunting is a significant cause of morbidity and mortality. Its pathophysiology is incompletely understood, but involves a flow-induced pulmonary arteriopathy characterized by endothelial cell dysfunction and vascular remodeling that alters pulmonary arterial vasoreactivity. There is a paucity of literature linking PH with left-to-right shunting due to ruptured sinus of Valsalva aneurysms (SOVA). We present a unique case of reversible, flow-associated PH due to a ruptured congenital right SOVA fistulizing into the right atrium (RA), with emphasis on non-invasive and invasive assessment of pulmonary hemodynamics before and after surgical intervention.https://doi.org/10.1177/2045894018760656 |
| spellingShingle | Basil Al-Sabeq Sabe De Ryan Davey A case of ruptured sinus of Valsalva aneurysm and reversible flow-induced pulmonary hypertension Pulmonary Circulation |
| title | A case of ruptured sinus of Valsalva aneurysm and reversible flow-induced pulmonary hypertension |
| title_full | A case of ruptured sinus of Valsalva aneurysm and reversible flow-induced pulmonary hypertension |
| title_fullStr | A case of ruptured sinus of Valsalva aneurysm and reversible flow-induced pulmonary hypertension |
| title_full_unstemmed | A case of ruptured sinus of Valsalva aneurysm and reversible flow-induced pulmonary hypertension |
| title_short | A case of ruptured sinus of Valsalva aneurysm and reversible flow-induced pulmonary hypertension |
| title_sort | case of ruptured sinus of valsalva aneurysm and reversible flow induced pulmonary hypertension |
| url | https://doi.org/10.1177/2045894018760656 |
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