Patient reported quality of life in young adults with sarcoma receiving care at a sarcoma center
BackgroundSarcomas are a diverse group of neoplasms that vary greatly in clinical presentation and responsiveness to treatment. Given the differences in the sites of involvement, rarity, and treatment modality, a multidisciplinary approach is required. Previous literature suggests patients with sarc...
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2022.871254/full |
| _version_ | 1828385041065967616 |
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| author | Jonathan R. Day Benjamin Miller Bradley T. Loeffler Sarah L. Mott Munir Tanas Melissa Curry Jonathan Davick Mohammed Milhem Varun Monga |
| author_facet | Jonathan R. Day Benjamin Miller Bradley T. Loeffler Sarah L. Mott Munir Tanas Melissa Curry Jonathan Davick Mohammed Milhem Varun Monga |
| author_sort | Jonathan R. Day |
| collection | DOAJ |
| description | BackgroundSarcomas are a diverse group of neoplasms that vary greatly in clinical presentation and responsiveness to treatment. Given the differences in the sites of involvement, rarity, and treatment modality, a multidisciplinary approach is required. Previous literature suggests patients with sarcoma suffer from poorer quality of life (QoL) especially physical and functional wellbeing. Adolescent and young adult (AYA) patients are an underrepresented population in cancer research and have differing factors influencing QoL.MethodsRetrospective analysis of Young Adult patients (age 18–39) enrolled in the Sarcoma Tissue Repository at University of Iowa. QoL was assessed using the self-report FACT-G questionnaire at enrollment and 12 months post-diagnosis; overall scores and the 4 wellbeing subscales (Physical, Emotional, Social, Functional) were calculated. Linear mixed effects models were used to measure the association between the rate of change in FACT-G subscale scores and baseline clinical, comorbidity, and treatment characteristics.Results49 patients were identified. 57.1% of patients had a malignancy involving an extremity. Mean FACT-G scores of overall wellbeing improved from baseline to 12 months (76.4 vs. 85.4, p < 0.01). Social and emotional wellbeing did not differ significantly between baseline and 12 months. Physical wellbeing (18.8 vs. 23.9, p < 0.01) and functional wellbeing (16.8 vs. 20.0, p< 0.01) scores improved from baseline to 12 months. No difference was seen for FACT-G overall scores for age, sex, laterality, marital status, performance status, having children, clinical stage, limb surgery, chemotherapy, or tumor size. A difference was demonstrated in physical wellbeing scores for patients with baseline limitation (ECOG 1-3) compared to those with no baseline limitation (ECOG 0) (p = 0.03). A difference was demonstrated in social wellbeing based on anatomical site (p = 0.02).ConclusionYoung adults with sarcoma treated at a tertiary center had improvements in overall reported QoL at 12 months from diagnosis. Overall baseline QoL scores on FACT-G were lower than the general adult population for YA patients with sarcoma but at 12 months became in line with general population norms. The improvements seen merit further investigation to evaluate how these change over the continuum of care. Quality of life changes may be useful outcomes of interest in sarcoma trials. |
| first_indexed | 2024-12-10T05:13:39Z |
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| language | English |
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| spelling | doaj.art-ab5e74da26294c69ad335f9bfb4bc0742022-12-22T02:01:02ZengFrontiers Media S.A.Frontiers in Psychology1664-10782022-09-011310.3389/fpsyg.2022.871254871254Patient reported quality of life in young adults with sarcoma receiving care at a sarcoma centerJonathan R. Day0Benjamin Miller1Bradley T. Loeffler2Sarah L. Mott3Munir Tanas4Melissa Curry5Jonathan Davick6Mohammed Milhem7Varun Monga8Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesDepartment of Orthopedics, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesHolden Comprehensive Cancer Center, Iowa City, IA, United StatesHolden Comprehensive Cancer Center, Iowa City, IA, United StatesDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesHolden Comprehensive Cancer Center, Iowa City, IA, United StatesDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesBackgroundSarcomas are a diverse group of neoplasms that vary greatly in clinical presentation and responsiveness to treatment. Given the differences in the sites of involvement, rarity, and treatment modality, a multidisciplinary approach is required. Previous literature suggests patients with sarcoma suffer from poorer quality of life (QoL) especially physical and functional wellbeing. Adolescent and young adult (AYA) patients are an underrepresented population in cancer research and have differing factors influencing QoL.MethodsRetrospective analysis of Young Adult patients (age 18–39) enrolled in the Sarcoma Tissue Repository at University of Iowa. QoL was assessed using the self-report FACT-G questionnaire at enrollment and 12 months post-diagnosis; overall scores and the 4 wellbeing subscales (Physical, Emotional, Social, Functional) were calculated. Linear mixed effects models were used to measure the association between the rate of change in FACT-G subscale scores and baseline clinical, comorbidity, and treatment characteristics.Results49 patients were identified. 57.1% of patients had a malignancy involving an extremity. Mean FACT-G scores of overall wellbeing improved from baseline to 12 months (76.4 vs. 85.4, p < 0.01). Social and emotional wellbeing did not differ significantly between baseline and 12 months. Physical wellbeing (18.8 vs. 23.9, p < 0.01) and functional wellbeing (16.8 vs. 20.0, p< 0.01) scores improved from baseline to 12 months. No difference was seen for FACT-G overall scores for age, sex, laterality, marital status, performance status, having children, clinical stage, limb surgery, chemotherapy, or tumor size. A difference was demonstrated in physical wellbeing scores for patients with baseline limitation (ECOG 1-3) compared to those with no baseline limitation (ECOG 0) (p = 0.03). A difference was demonstrated in social wellbeing based on anatomical site (p = 0.02).ConclusionYoung adults with sarcoma treated at a tertiary center had improvements in overall reported QoL at 12 months from diagnosis. Overall baseline QoL scores on FACT-G were lower than the general adult population for YA patients with sarcoma but at 12 months became in line with general population norms. The improvements seen merit further investigation to evaluate how these change over the continuum of care. Quality of life changes may be useful outcomes of interest in sarcoma trials.https://www.frontiersin.org/articles/10.3389/fpsyg.2022.871254/fullquality of lifesarcomayoung adultoncology-disciplineFACT-G |
| spellingShingle | Jonathan R. Day Benjamin Miller Bradley T. Loeffler Sarah L. Mott Munir Tanas Melissa Curry Jonathan Davick Mohammed Milhem Varun Monga Patient reported quality of life in young adults with sarcoma receiving care at a sarcoma center Frontiers in Psychology quality of life sarcoma young adult oncology-discipline FACT-G |
| title | Patient reported quality of life in young adults with sarcoma receiving care at a sarcoma center |
| title_full | Patient reported quality of life in young adults with sarcoma receiving care at a sarcoma center |
| title_fullStr | Patient reported quality of life in young adults with sarcoma receiving care at a sarcoma center |
| title_full_unstemmed | Patient reported quality of life in young adults with sarcoma receiving care at a sarcoma center |
| title_short | Patient reported quality of life in young adults with sarcoma receiving care at a sarcoma center |
| title_sort | patient reported quality of life in young adults with sarcoma receiving care at a sarcoma center |
| topic | quality of life sarcoma young adult oncology-discipline FACT-G |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2022.871254/full |
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