Photoacoustic Imaging Probes Based on Tetrapyrroles and Related Compounds
Photoacoustic imaging (PAI) is a rapidly evolving field in molecular imaging that enables imaging in the depths of ultrasound and with the sensitivity of optical modalities. PAI bases on the photoexcitation of a chromophore, which converts the absorbed light into thermal energy, causing an acoustic...
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| Format: | Article |
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MDPI AG
2020-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/9/3082 |
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| author | Jean Michel Merkes Leiming Zhu Srishti Ballabh Bahukhandi Magnus Rueping Fabian Kiessling Srinivas Banala |
| author_facet | Jean Michel Merkes Leiming Zhu Srishti Ballabh Bahukhandi Magnus Rueping Fabian Kiessling Srinivas Banala |
| author_sort | Jean Michel Merkes |
| collection | DOAJ |
| description | Photoacoustic imaging (PAI) is a rapidly evolving field in molecular imaging that enables imaging in the depths of ultrasound and with the sensitivity of optical modalities. PAI bases on the photoexcitation of a chromophore, which converts the absorbed light into thermal energy, causing an acoustic pressure wave that can be captured with ultrasound transducers, in generating an image. For in vivo imaging, chromophores strongly absorbing in the near-infrared range (NIR; > 680 nm) are required. As tetrapyrroles have a long history in biomedical applications, novel tetrapyrroles and inspired mimics have been pursued as potentially suitable contrast agents for PAI. The goal of this review is to summarize the current state of the art in PAI applications using tetrapyrroles and related macrocycles inspired by it, highlighting those compounds exhibiting strong NIR-absorption. Furthermore, we discuss the current developments of other absorbers for in vivo photoacoustic (PA) applications. |
| first_indexed | 2024-03-10T20:12:41Z |
| format | Article |
| id | doaj.art-ab6068c2078e44adac6ff515b1c9ec48 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:12:41Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ab6068c2078e44adac6ff515b1c9ec482023-11-19T22:50:37ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01219308210.3390/ijms21093082Photoacoustic Imaging Probes Based on Tetrapyrroles and Related CompoundsJean Michel Merkes0Leiming Zhu1Srishti Ballabh Bahukhandi2Magnus Rueping3Fabian Kiessling4Srinivas Banala5Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, GermanyInstitute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, GermanyInstitute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, GermanyInstitute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, GermanyInstitute for Experimental Molecular Imaging, Forckenbeckstrasse 55, RWTH Aachen, University Clinic, 52074 Aachen, GermanyInstitute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, GermanyPhotoacoustic imaging (PAI) is a rapidly evolving field in molecular imaging that enables imaging in the depths of ultrasound and with the sensitivity of optical modalities. PAI bases on the photoexcitation of a chromophore, which converts the absorbed light into thermal energy, causing an acoustic pressure wave that can be captured with ultrasound transducers, in generating an image. For in vivo imaging, chromophores strongly absorbing in the near-infrared range (NIR; > 680 nm) are required. As tetrapyrroles have a long history in biomedical applications, novel tetrapyrroles and inspired mimics have been pursued as potentially suitable contrast agents for PAI. The goal of this review is to summarize the current state of the art in PAI applications using tetrapyrroles and related macrocycles inspired by it, highlighting those compounds exhibiting strong NIR-absorption. Furthermore, we discuss the current developments of other absorbers for in vivo photoacoustic (PA) applications.https://www.mdpi.com/1422-0067/21/9/3082porphyrinscore-modified porphyrinsphthalocyaninesactivatable probesazacalixphyrinnear-infrared (NIR) dyes |
| spellingShingle | Jean Michel Merkes Leiming Zhu Srishti Ballabh Bahukhandi Magnus Rueping Fabian Kiessling Srinivas Banala Photoacoustic Imaging Probes Based on Tetrapyrroles and Related Compounds International Journal of Molecular Sciences porphyrins core-modified porphyrins phthalocyanines activatable probes azacalixphyrin near-infrared (NIR) dyes |
| title | Photoacoustic Imaging Probes Based on Tetrapyrroles and Related Compounds |
| title_full | Photoacoustic Imaging Probes Based on Tetrapyrroles and Related Compounds |
| title_fullStr | Photoacoustic Imaging Probes Based on Tetrapyrroles and Related Compounds |
| title_full_unstemmed | Photoacoustic Imaging Probes Based on Tetrapyrroles and Related Compounds |
| title_short | Photoacoustic Imaging Probes Based on Tetrapyrroles and Related Compounds |
| title_sort | photoacoustic imaging probes based on tetrapyrroles and related compounds |
| topic | porphyrins core-modified porphyrins phthalocyanines activatable probes azacalixphyrin near-infrared (NIR) dyes |
| url | https://www.mdpi.com/1422-0067/21/9/3082 |
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