Triglyceride-glucose index in the prediction of clinical outcomes after successful recanalization for coronary chronic total occlusions
Abstract Background Triglyceride-glucose index (TyG) has been widely used to predict cardiovascular outcomes. However, it remains unclear whether TyG holds prognostic significance for patients with coronary chronic total occlusions (CTO). Thus, our study aimed to evaluate the predictive accuracy and...
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| Language: | English |
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BMC
2023-11-01
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| Series: | Cardiovascular Diabetology |
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| Online Access: | https://doi.org/10.1186/s12933-023-02037-6 |
| _version_ | 1797630477305118720 |
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| author | Yu Yang Mengqing Ma Jian Zhang Shiyu Jin Dingxin Zhang Xianhe Lin |
| author_facet | Yu Yang Mengqing Ma Jian Zhang Shiyu Jin Dingxin Zhang Xianhe Lin |
| author_sort | Yu Yang |
| collection | DOAJ |
| description | Abstract Background Triglyceride-glucose index (TyG) has been widely used to predict cardiovascular outcomes. However, it remains unclear whether TyG holds prognostic significance for patients with coronary chronic total occlusions (CTO). Thus, our study aimed to evaluate the predictive accuracy and prognostic value of TyG in individuals who underwent successful percutaneous coronary intervention (PCI) for CTO. Methods A total of 331 consecutive patients with ≥ 1 successful CTO-PCI were included. The baseline and angiographic data were acquired. The duration of follow-up ranged from 32 to 79 months, with a median of 44 months and an interquartile range of 39 to 67 months. The primary outcome measured was the occurrence of major adverse cardiac and cerebrovascular events (MACCE), including mortality, target vessel revascularization, recurrent myocardial infarction, and stroke. Results After controlling for confounders, multivariate Cox regression analysis revealed that TyG remained statistically significant, regardless of being a continuous or categorical variable. In the partially adjusted regression model, the Hazard ratio (95%CI) for MACCE was 2.54 (1.12–5.79) in tertile 3 and 1.61 (1.22–2.12) per SD increase in the TyG.Kaplan-Meier survival analysis demonstrated significant differences in MACCE-free survival rates across tertiles of the TyG, as indicated by the log-rank test (p = 0.001). ROC analysis was conducted to evaluate the predictive ability of TyG for MACCE, resulting in an AUC of 0.677. Conclusion The TyG index demonstrates independent predictive capabilities for MACCE in patients who have undergone successful CTO-PCI. These findings suggest that TyG holds the potential as a valuable tool in risk stratification and the identification of patients who may benefit from early intervention in the management of CTO. |
| first_indexed | 2024-03-11T11:08:40Z |
| format | Article |
| id | doaj.art-ab617ecc18ca44208a9ddb566cdcfae0 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-03-11T11:08:40Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-ab617ecc18ca44208a9ddb566cdcfae02023-11-12T12:05:52ZengBMCCardiovascular Diabetology1475-28402023-11-0122111010.1186/s12933-023-02037-6Triglyceride-glucose index in the prediction of clinical outcomes after successful recanalization for coronary chronic total occlusionsYu Yang0Mengqing Ma1Jian Zhang2Shiyu Jin3Dingxin Zhang4Xianhe Lin5Department of cardiology, The First Affiliated Hospital of Anhui Medical UniversityDepartment of cardiology, The First Affiliated Hospital of Anhui Medical UniversityDepartment of cardiology, The First Affiliated Hospital of Anhui Medical UniversityDepartment of cardiology, The First Affiliated Hospital of Anhui Medical UniversityDepartment of cardiology, The First Affiliated Hospital of Anhui Medical UniversityDepartment of cardiology, The First Affiliated Hospital of Anhui Medical UniversityAbstract Background Triglyceride-glucose index (TyG) has been widely used to predict cardiovascular outcomes. However, it remains unclear whether TyG holds prognostic significance for patients with coronary chronic total occlusions (CTO). Thus, our study aimed to evaluate the predictive accuracy and prognostic value of TyG in individuals who underwent successful percutaneous coronary intervention (PCI) for CTO. Methods A total of 331 consecutive patients with ≥ 1 successful CTO-PCI were included. The baseline and angiographic data were acquired. The duration of follow-up ranged from 32 to 79 months, with a median of 44 months and an interquartile range of 39 to 67 months. The primary outcome measured was the occurrence of major adverse cardiac and cerebrovascular events (MACCE), including mortality, target vessel revascularization, recurrent myocardial infarction, and stroke. Results After controlling for confounders, multivariate Cox regression analysis revealed that TyG remained statistically significant, regardless of being a continuous or categorical variable. In the partially adjusted regression model, the Hazard ratio (95%CI) for MACCE was 2.54 (1.12–5.79) in tertile 3 and 1.61 (1.22–2.12) per SD increase in the TyG.Kaplan-Meier survival analysis demonstrated significant differences in MACCE-free survival rates across tertiles of the TyG, as indicated by the log-rank test (p = 0.001). ROC analysis was conducted to evaluate the predictive ability of TyG for MACCE, resulting in an AUC of 0.677. Conclusion The TyG index demonstrates independent predictive capabilities for MACCE in patients who have undergone successful CTO-PCI. These findings suggest that TyG holds the potential as a valuable tool in risk stratification and the identification of patients who may benefit from early intervention in the management of CTO.https://doi.org/10.1186/s12933-023-02037-6Chronic total occlusionTriglyceride-glucose indexInsulin resistancePercutaneous coronary interventionPrognosis |
| spellingShingle | Yu Yang Mengqing Ma Jian Zhang Shiyu Jin Dingxin Zhang Xianhe Lin Triglyceride-glucose index in the prediction of clinical outcomes after successful recanalization for coronary chronic total occlusions Cardiovascular Diabetology Chronic total occlusion Triglyceride-glucose index Insulin resistance Percutaneous coronary intervention Prognosis |
| title | Triglyceride-glucose index in the prediction of clinical outcomes after successful recanalization for coronary chronic total occlusions |
| title_full | Triglyceride-glucose index in the prediction of clinical outcomes after successful recanalization for coronary chronic total occlusions |
| title_fullStr | Triglyceride-glucose index in the prediction of clinical outcomes after successful recanalization for coronary chronic total occlusions |
| title_full_unstemmed | Triglyceride-glucose index in the prediction of clinical outcomes after successful recanalization for coronary chronic total occlusions |
| title_short | Triglyceride-glucose index in the prediction of clinical outcomes after successful recanalization for coronary chronic total occlusions |
| title_sort | triglyceride glucose index in the prediction of clinical outcomes after successful recanalization for coronary chronic total occlusions |
| topic | Chronic total occlusion Triglyceride-glucose index Insulin resistance Percutaneous coronary intervention Prognosis |
| url | https://doi.org/10.1186/s12933-023-02037-6 |
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