Overview on Osteoporosis, Periodontitis and Oral Dysbiosis: The Emerging Role of Oral Microbiota
Osteoporosis (OP) is a bone disease consisting of a progressive loss of bone mineral density (BMD) and therefore resulting in greater susceptibility to fractures. OP shares a number of risk factors and demographic characteristics with periodontitis (PD), a bacteria-induced chronic inflammation of pe...
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| Format: | Article |
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MDPI AG
2020-08-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/10/17/6000 |
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| author | Maria Contaldo Annalisa Itro Carlo Lajolo Gioele Gioco Francesco Inchingolo Rosario Serpico |
| author_facet | Maria Contaldo Annalisa Itro Carlo Lajolo Gioele Gioco Francesco Inchingolo Rosario Serpico |
| author_sort | Maria Contaldo |
| collection | DOAJ |
| description | Osteoporosis (OP) is a bone disease consisting of a progressive loss of bone mineral density (BMD) and therefore resulting in greater susceptibility to fractures. OP shares a number of risk factors and demographic characteristics with periodontitis (PD), a bacteria-induced chronic inflammation of periodontal structures that leads to loss of alveolar bone and teeth. In the last decade, with the advent of gut and oral microbiome studies and profiling, a growing diagnostic and prognostic significance has been attributed to dysbiosis associated with various systemic and organ-specific pathologies. This evidence has inspired research on modulating the microbiota to restore health by the use of prebiotics and probiotics. The aim of this work is to overview the bidirectional interrelationships between OP and PD, reporting the most recent evidence on triggering factors and, mainly, the role of gut and oral dysbiosis in the onset and progression of both OP and PD, with the perspective in their therapy. |
| first_indexed | 2024-03-10T16:43:09Z |
| format | Article |
| id | doaj.art-ab61f3fb68c6449ea5a31c5409c680e8 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T16:43:09Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-ab61f3fb68c6449ea5a31c5409c680e82023-11-20T11:51:53ZengMDPI AGApplied Sciences2076-34172020-08-011017600010.3390/app10176000Overview on Osteoporosis, Periodontitis and Oral Dysbiosis: The Emerging Role of Oral MicrobiotaMaria Contaldo0Annalisa Itro1Carlo Lajolo2Gioele Gioco3Francesco Inchingolo4Rosario Serpico5Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 6, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 6, 80138 Naples, ItalyHead and Neck Department, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma Università Cattolica del Sacro Cuore, Largo A. Gemelli, 8, 00168 Rome, ItalyHead and Neck Department, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma Università Cattolica del Sacro Cuore, Largo A. Gemelli, 8, 00168 Rome, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare 11, 70124 Bari, ItalyMultidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 6, 80138 Naples, ItalyOsteoporosis (OP) is a bone disease consisting of a progressive loss of bone mineral density (BMD) and therefore resulting in greater susceptibility to fractures. OP shares a number of risk factors and demographic characteristics with periodontitis (PD), a bacteria-induced chronic inflammation of periodontal structures that leads to loss of alveolar bone and teeth. In the last decade, with the advent of gut and oral microbiome studies and profiling, a growing diagnostic and prognostic significance has been attributed to dysbiosis associated with various systemic and organ-specific pathologies. This evidence has inspired research on modulating the microbiota to restore health by the use of prebiotics and probiotics. The aim of this work is to overview the bidirectional interrelationships between OP and PD, reporting the most recent evidence on triggering factors and, mainly, the role of gut and oral dysbiosis in the onset and progression of both OP and PD, with the perspective in their therapy.https://www.mdpi.com/2076-3417/10/17/6000osteoporosisperiodontitisoral healthbone and bones/metabolismmicrobiomemicrobiota |
| spellingShingle | Maria Contaldo Annalisa Itro Carlo Lajolo Gioele Gioco Francesco Inchingolo Rosario Serpico Overview on Osteoporosis, Periodontitis and Oral Dysbiosis: The Emerging Role of Oral Microbiota Applied Sciences osteoporosis periodontitis oral health bone and bones/metabolism microbiome microbiota |
| title | Overview on Osteoporosis, Periodontitis and Oral Dysbiosis: The Emerging Role of Oral Microbiota |
| title_full | Overview on Osteoporosis, Periodontitis and Oral Dysbiosis: The Emerging Role of Oral Microbiota |
| title_fullStr | Overview on Osteoporosis, Periodontitis and Oral Dysbiosis: The Emerging Role of Oral Microbiota |
| title_full_unstemmed | Overview on Osteoporosis, Periodontitis and Oral Dysbiosis: The Emerging Role of Oral Microbiota |
| title_short | Overview on Osteoporosis, Periodontitis and Oral Dysbiosis: The Emerging Role of Oral Microbiota |
| title_sort | overview on osteoporosis periodontitis and oral dysbiosis the emerging role of oral microbiota |
| topic | osteoporosis periodontitis oral health bone and bones/metabolism microbiome microbiota |
| url | https://www.mdpi.com/2076-3417/10/17/6000 |
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