SnSe Nanosheets Mimic Lactate Dehydrogenase to Reverse Tumor Acid Microenvironment Metabolism for Enhancement of Tumor Therapy

SnSe Nanosheets Mimic Lactate Dehydrogenase to Reverse Tumor Acid Microenvironment Metabolism for Enhancement of Tumor Therapy

The acidic tumor microenvironment (TME) is unfriendly to the activity and function of immune cells in the TME. Here, we report inorganic nanozymes (i.e., SnSe NSs) that mimic the catalytic activity of lactate dehydrogenase to degrade lactate to pyruvate, contributing to the metabolic treatment of tu...

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Bibliographic Details
Main Authors: Heng Wang, Beilei Wang, Jie Jiang, Yi Wu, Anning Song, Xiaoyu Wang, Chenlu Yao, Huaxing Dai, Jialu Xu, Yue Zhang, Qingle Ma, Fang Xu, Ruibin Li, Chao Wang
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
lactate
nanozyme
tumor acidity
tumor microenvironment
Online Access:https://www.mdpi.com/1420-3049/27/23/8552

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