Neuronal reactivation during post-learning sleep consolidates long-term memory in Drosophila
Animals consolidate some, but not all, learning experiences into long-term memory. Across the animal kingdom, sleep has been found to have a beneficial effect on the consolidation of recently formed memories into long-term storage. However, the underlying mechanisms of sleep dependent memory consoli...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2019-02-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/42786 |
| _version_ | 1811235863170908160 |
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| author | Ugur Dag Zhengchang Lei Jasmine Q Le Allan Wong Daniel Bushey Krystyna Keleman |
| author_facet | Ugur Dag Zhengchang Lei Jasmine Q Le Allan Wong Daniel Bushey Krystyna Keleman |
| author_sort | Ugur Dag |
| collection | DOAJ |
| description | Animals consolidate some, but not all, learning experiences into long-term memory. Across the animal kingdom, sleep has been found to have a beneficial effect on the consolidation of recently formed memories into long-term storage. However, the underlying mechanisms of sleep dependent memory consolidation are poorly understood. Here, we show that consolidation of courtship long-term memory in Drosophila is mediated by reactivation during sleep of dopaminergic neurons that were earlier involved in memory acquisition. We identify specific fan-shaped body neurons that induce sleep after the learning experience and activate dopaminergic neurons for memory consolidation. Thus, we provide a direct link between sleep, neuronal reactivation of dopaminergic neurons, and memory consolidation. |
| first_indexed | 2024-04-12T11:59:23Z |
| format | Article |
| id | doaj.art-ab6a300edce8428ebfdc0b58ee90137b |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T11:59:23Z |
| publishDate | 2019-02-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-ab6a300edce8428ebfdc0b58ee90137b2022-12-22T03:33:53ZengeLife Sciences Publications LtdeLife2050-084X2019-02-01810.7554/eLife.42786Neuronal reactivation during post-learning sleep consolidates long-term memory in DrosophilaUgur Dag0https://orcid.org/0000-0001-6937-5722Zhengchang Lei1https://orcid.org/0000-0002-6475-5010Jasmine Q Le2https://orcid.org/0000-0003-4159-8830Allan Wong3https://orcid.org/0000-0002-8492-2162Daniel Bushey4https://orcid.org/0000-0001-9258-6579Krystyna Keleman5https://orcid.org/0000-0003-2044-1981Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesAnimals consolidate some, but not all, learning experiences into long-term memory. Across the animal kingdom, sleep has been found to have a beneficial effect on the consolidation of recently formed memories into long-term storage. However, the underlying mechanisms of sleep dependent memory consolidation are poorly understood. Here, we show that consolidation of courtship long-term memory in Drosophila is mediated by reactivation during sleep of dopaminergic neurons that were earlier involved in memory acquisition. We identify specific fan-shaped body neurons that induce sleep after the learning experience and activate dopaminergic neurons for memory consolidation. Thus, we provide a direct link between sleep, neuronal reactivation of dopaminergic neurons, and memory consolidation.https://elifesciences.org/articles/42786long-term memory consolidationsleepneuronal reactivation |
| spellingShingle | Ugur Dag Zhengchang Lei Jasmine Q Le Allan Wong Daniel Bushey Krystyna Keleman Neuronal reactivation during post-learning sleep consolidates long-term memory in Drosophila eLife long-term memory consolidation sleep neuronal reactivation |
| title | Neuronal reactivation during post-learning sleep consolidates long-term memory in Drosophila |
| title_full | Neuronal reactivation during post-learning sleep consolidates long-term memory in Drosophila |
| title_fullStr | Neuronal reactivation during post-learning sleep consolidates long-term memory in Drosophila |
| title_full_unstemmed | Neuronal reactivation during post-learning sleep consolidates long-term memory in Drosophila |
| title_short | Neuronal reactivation during post-learning sleep consolidates long-term memory in Drosophila |
| title_sort | neuronal reactivation during post learning sleep consolidates long term memory in drosophila |
| topic | long-term memory consolidation sleep neuronal reactivation |
| url | https://elifesciences.org/articles/42786 |
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