Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis.

Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis.

BACKGROUND:We investigated sera from elderly subjects with and without age-related macular degeneration (AMD) for presence of autoantibodies (AAbs) against human macular antigens and characterized their identity. METHODS:Sera were collected from participants in the Age-Related Maculopathy Ancillary...

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Main Authors: Alessandro Iannaccone, Francesco Giorgianni, David D New, T J Hollingsworth, Allison Umfress, Albert H Alhatem, Indira Neeli, Nataliya I Lenchik, Barbara J Jennings, Jorge I Calzada, Suzanne Satterfield, Dennis Mathews, Rocio I Diaz, Tamara Harris, Karen C Johnson, Steve Charles, Stephen B Kritchevsky, Ivan C Gerling, Sarka Beranova-Giorgianni, Marko Z Radic, Health ABC study
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4696815?pdf=render

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