Development and Biocompatibility Evaluation of Photocatalytic TiO2/Reduced Graphene Oxide-Based Nanoparticles Designed for Self-Cleaning Purposes
Graphene is widely used in nanotechnologies to amplify the photocatalytic activity of TiO2, but the development of TiO2/graphene composites imposes the assessment of their risk to human and environmental health. Therefore, reduced graphene oxide was decorated with two types of TiO2 particles co-dope...
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MDPI AG
2017-09-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/7/9/279 |
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| author | Ionela Cristina Nica Miruna S. Stan Marcela Popa Mariana Carmen Chifiriuc Gratiela G. Pircalabioru Veronica Lazar Iuliana Dumitrescu Lucian Diamandescu Marcel Feder Mihaela Baibarac Marin Cernea Valentin Adrian Maraloiu Traian Popescu Anca Dinischiotu |
| author_facet | Ionela Cristina Nica Miruna S. Stan Marcela Popa Mariana Carmen Chifiriuc Gratiela G. Pircalabioru Veronica Lazar Iuliana Dumitrescu Lucian Diamandescu Marcel Feder Mihaela Baibarac Marin Cernea Valentin Adrian Maraloiu Traian Popescu Anca Dinischiotu |
| author_sort | Ionela Cristina Nica |
| collection | DOAJ |
| description | Graphene is widely used in nanotechnologies to amplify the photocatalytic activity of TiO2, but the development of TiO2/graphene composites imposes the assessment of their risk to human and environmental health. Therefore, reduced graphene oxide was decorated with two types of TiO2 particles co-doped with 1% iron and nitrogen, one of them being obtained by a simultaneous precipitation of Ti3+ and Fe3+ ions to achieve their uniform distribution, and the other one after a sequential precipitation of these two cations for a higher concentration of iron on the surface. Physico-chemical characterization, photocatalytic efficiency evaluation, antimicrobial analysis and biocompatibility assessment were performed for these TiO2-based composites. The best photocatalytic efficiency was found for the sample with iron atoms localized at the sample surface. A very good anti-inhibitory activity was obtained for both samples against biofilms of Gram-positive and Gram-negative strains. Exposure of human skin and lung fibroblasts to photocatalysts did not significantly affect cell viability, but analysis of oxidative stress showed increased levels of carbonyl groups and advanced oxidation protein products for both cell lines after 48 h of incubation. Our findings are of major importance by providing useful knowledge for future photocatalytic self-cleaning and biomedical applications of graphene-based materials. |
| first_indexed | 2024-04-13T17:40:47Z |
| format | Article |
| id | doaj.art-ab6c3fa3b7c14b838744bf3a9ef0c407 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-04-13T17:40:47Z |
| publishDate | 2017-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-ab6c3fa3b7c14b838744bf3a9ef0c4072022-12-22T02:37:12ZengMDPI AGNanomaterials2079-49912017-09-017927910.3390/nano7090279nano7090279Development and Biocompatibility Evaluation of Photocatalytic TiO2/Reduced Graphene Oxide-Based Nanoparticles Designed for Self-Cleaning PurposesIonela Cristina Nica0Miruna S. Stan1Marcela Popa2Mariana Carmen Chifiriuc3Gratiela G. Pircalabioru4Veronica Lazar5Iuliana Dumitrescu6Lucian Diamandescu7Marcel Feder8Mihaela Baibarac9Marin Cernea10Valentin Adrian Maraloiu11Traian Popescu12Anca Dinischiotu13Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, RomaniaDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, RomaniaDepartment of Botanic-Microbiology, Faculty of Biology, University of Bucharest, 1-3 Aleea Portocalelor, 060101 Bucharest, RomaniaDepartment of Botanic-Microbiology, Faculty of Biology, University of Bucharest, 1-3 Aleea Portocalelor, 060101 Bucharest, RomaniaDepartment of Botanic-Microbiology, Faculty of Biology, University of Bucharest, 1-3 Aleea Portocalelor, 060101 Bucharest, RomaniaDepartment of Botanic-Microbiology, Faculty of Biology, University of Bucharest, 1-3 Aleea Portocalelor, 060101 Bucharest, RomaniaNational R&D Institute for Textiles and Leather Bucharest (INCDTP), 16 Lucretiu Patrascanu, 030508 Bucharest, RomaniaNational Institute of Materials Physics (NIMP), Atomistilor 405A, 077125 Bucharest-Magurele, RomaniaNational Institute of Materials Physics (NIMP), Atomistilor 405A, 077125 Bucharest-Magurele, RomaniaNational Institute of Materials Physics (NIMP), Atomistilor 405A, 077125 Bucharest-Magurele, RomaniaNational Institute of Materials Physics (NIMP), Atomistilor 405A, 077125 Bucharest-Magurele, RomaniaNational Institute of Materials Physics (NIMP), Atomistilor 405A, 077125 Bucharest-Magurele, RomaniaNational Institute of Materials Physics (NIMP), Atomistilor 405A, 077125 Bucharest-Magurele, RomaniaDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, RomaniaGraphene is widely used in nanotechnologies to amplify the photocatalytic activity of TiO2, but the development of TiO2/graphene composites imposes the assessment of their risk to human and environmental health. Therefore, reduced graphene oxide was decorated with two types of TiO2 particles co-doped with 1% iron and nitrogen, one of them being obtained by a simultaneous precipitation of Ti3+ and Fe3+ ions to achieve their uniform distribution, and the other one after a sequential precipitation of these two cations for a higher concentration of iron on the surface. Physico-chemical characterization, photocatalytic efficiency evaluation, antimicrobial analysis and biocompatibility assessment were performed for these TiO2-based composites. The best photocatalytic efficiency was found for the sample with iron atoms localized at the sample surface. A very good anti-inhibitory activity was obtained for both samples against biofilms of Gram-positive and Gram-negative strains. Exposure of human skin and lung fibroblasts to photocatalysts did not significantly affect cell viability, but analysis of oxidative stress showed increased levels of carbonyl groups and advanced oxidation protein products for both cell lines after 48 h of incubation. Our findings are of major importance by providing useful knowledge for future photocatalytic self-cleaning and biomedical applications of graphene-based materials.https://www.mdpi.com/2079-4991/7/9/279titanium dioxidephotocatalystsreduced graphene oxideoxidative stressantimicrobialself-cleaning |
| spellingShingle | Ionela Cristina Nica Miruna S. Stan Marcela Popa Mariana Carmen Chifiriuc Gratiela G. Pircalabioru Veronica Lazar Iuliana Dumitrescu Lucian Diamandescu Marcel Feder Mihaela Baibarac Marin Cernea Valentin Adrian Maraloiu Traian Popescu Anca Dinischiotu Development and Biocompatibility Evaluation of Photocatalytic TiO2/Reduced Graphene Oxide-Based Nanoparticles Designed for Self-Cleaning Purposes Nanomaterials titanium dioxide photocatalysts reduced graphene oxide oxidative stress antimicrobial self-cleaning |
| title | Development and Biocompatibility Evaluation of Photocatalytic TiO2/Reduced Graphene Oxide-Based Nanoparticles Designed for Self-Cleaning Purposes |
| title_full | Development and Biocompatibility Evaluation of Photocatalytic TiO2/Reduced Graphene Oxide-Based Nanoparticles Designed for Self-Cleaning Purposes |
| title_fullStr | Development and Biocompatibility Evaluation of Photocatalytic TiO2/Reduced Graphene Oxide-Based Nanoparticles Designed for Self-Cleaning Purposes |
| title_full_unstemmed | Development and Biocompatibility Evaluation of Photocatalytic TiO2/Reduced Graphene Oxide-Based Nanoparticles Designed for Self-Cleaning Purposes |
| title_short | Development and Biocompatibility Evaluation of Photocatalytic TiO2/Reduced Graphene Oxide-Based Nanoparticles Designed for Self-Cleaning Purposes |
| title_sort | development and biocompatibility evaluation of photocatalytic tio2 reduced graphene oxide based nanoparticles designed for self cleaning purposes |
| topic | titanium dioxide photocatalysts reduced graphene oxide oxidative stress antimicrobial self-cleaning |
| url | https://www.mdpi.com/2079-4991/7/9/279 |
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