MicroRNA‐204‐5p: A pivotal tumor suppressor
Abstract MicroRNAs (miRNAs) are a class of non‐coding single‐stranded RNA molecules with a length of approximately 18‐25 nt nucleotides that regulate gene expression post‐transcriptionally. MiR‐204‐5p originates from the sixth intron of the transient receptor potential cation channel subfamily M mem...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-02-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.5077 |
| _version_ | 1797903119362818048 |
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| author | Fan Yang Zehua Bian Peiwen Xu Shengbai Sun Zhaohui Huang |
| author_facet | Fan Yang Zehua Bian Peiwen Xu Shengbai Sun Zhaohui Huang |
| author_sort | Fan Yang |
| collection | DOAJ |
| description | Abstract MicroRNAs (miRNAs) are a class of non‐coding single‐stranded RNA molecules with a length of approximately 18‐25 nt nucleotides that regulate gene expression post‐transcriptionally. MiR‐204‐5p originates from the sixth intron of the transient receptor potential cation channel subfamily M member 3 (TRPM3) gene. MiR‐204‐5p is frequently downregulated in various cancer types and is related to the clinicopathological characteristics and prognosis of cancer patients. So far, many studies have determined that miR‐204‐5p functions as a tumor suppressor for its extensive and powerful capacity to inhibit tumor proliferation, metastasis, autophagy, and chemoresistance in multiple cancer types. MiR‐204‐5p appears to be a promising prognostic biomarker and a therapeutic target for human cancers. This review summarized the latest advances on the role of miR‐204‐5p in human cancers. |
| first_indexed | 2024-04-10T09:27:56Z |
| format | Article |
| id | doaj.art-ab6c7e9783944ce1983dc24e26e1f604 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-10T09:27:56Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-ab6c7e9783944ce1983dc24e26e1f6042023-02-19T18:54:07ZengWileyCancer Medicine2045-76342023-02-011233185320010.1002/cam4.5077MicroRNA‐204‐5p: A pivotal tumor suppressorFan Yang0Zehua Bian1Peiwen Xu2Shengbai Sun3Zhaohui Huang4Wuxi Cancer Institute Affiliated Hospital of Jiangnan University Wuxi Jiangsu ChinaWuxi Cancer Institute Affiliated Hospital of Jiangnan University Wuxi Jiangsu ChinaWuxi Cancer Institute Affiliated Hospital of Jiangnan University Wuxi Jiangsu ChinaWuxi Cancer Institute Affiliated Hospital of Jiangnan University Wuxi Jiangsu ChinaWuxi Cancer Institute Affiliated Hospital of Jiangnan University Wuxi Jiangsu ChinaAbstract MicroRNAs (miRNAs) are a class of non‐coding single‐stranded RNA molecules with a length of approximately 18‐25 nt nucleotides that regulate gene expression post‐transcriptionally. MiR‐204‐5p originates from the sixth intron of the transient receptor potential cation channel subfamily M member 3 (TRPM3) gene. MiR‐204‐5p is frequently downregulated in various cancer types and is related to the clinicopathological characteristics and prognosis of cancer patients. So far, many studies have determined that miR‐204‐5p functions as a tumor suppressor for its extensive and powerful capacity to inhibit tumor proliferation, metastasis, autophagy, and chemoresistance in multiple cancer types. MiR‐204‐5p appears to be a promising prognostic biomarker and a therapeutic target for human cancers. This review summarized the latest advances on the role of miR‐204‐5p in human cancers.https://doi.org/10.1002/cam4.5077microRNAmiR‐204‐5ptumor suppressorcancergene regulation |
| spellingShingle | Fan Yang Zehua Bian Peiwen Xu Shengbai Sun Zhaohui Huang MicroRNA‐204‐5p: A pivotal tumor suppressor Cancer Medicine microRNA miR‐204‐5p tumor suppressor cancer gene regulation |
| title | MicroRNA‐204‐5p: A pivotal tumor suppressor |
| title_full | MicroRNA‐204‐5p: A pivotal tumor suppressor |
| title_fullStr | MicroRNA‐204‐5p: A pivotal tumor suppressor |
| title_full_unstemmed | MicroRNA‐204‐5p: A pivotal tumor suppressor |
| title_short | MicroRNA‐204‐5p: A pivotal tumor suppressor |
| title_sort | microrna 204 5p a pivotal tumor suppressor |
| topic | microRNA miR‐204‐5p tumor suppressor cancer gene regulation |
| url | https://doi.org/10.1002/cam4.5077 |
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