Development of spray-dried powder hand sanitiser with prolonged effectivity
Abstract Since the outbreak of the COVID-19 pandemic, the use of hand sanitisers has become an inseparable part of our personal hygiene. However, the short-term effect and the need for frequent application are shortcomings that impair the overall protection. Another aspect is that repeated use of so...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-55503-w |
| _version_ | 1797275298732965888 |
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| author | Lucie Večerková Lucie Mašková Zdeněk Knejzlík Ondřej Kašpar Viola Tokárová |
| author_facet | Lucie Večerková Lucie Mašková Zdeněk Knejzlík Ondřej Kašpar Viola Tokárová |
| author_sort | Lucie Večerková |
| collection | DOAJ |
| description | Abstract Since the outbreak of the COVID-19 pandemic, the use of hand sanitisers has become an inseparable part of our personal hygiene. However, the short-term effect and the need for frequent application are shortcomings that impair the overall protection. Another aspect is that repeated use of some products (typically alcohol-based) may cause skin irritation or eventually more severe health problems. This work proposes spray-drying as a suitable method for the preparation of swellable chitosan carriers, allowing for encapsulation and sustained release of antibacterial chlorhexidine digluconate as a model active substance. After application to hands, micron-sized particles preferentially accommodate space between epidermal ridges, protected against attrition. Thanks to their small size (d < 10 µm), particles are comfortable to carry since they are not recognisable by somatosensory receptors. The performance of formulations with various amounts of chlorhexidine and cross-linker was tested and compared with selected commercial disinfectants available on the Czech market (ethanol gel and alcoholic solution with chlorhexidine) against E. coli and S. epidermidis. The real-life performance was investigated with twelve volunteers performing various activities for up to 2 h. Finally, a replica of the human index finger with accurately captured micro-topology was proposed and compared with volunteers’ fingers concerning the total amount of adhered and detached particles. |
| first_indexed | 2024-03-07T15:11:18Z |
| format | Article |
| id | doaj.art-ab6cc374d15846d08f21d2744ee83c68 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:11:18Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ab6cc374d15846d08f21d2744ee83c682024-03-05T18:38:37ZengNature PortfolioScientific Reports2045-23222024-02-0114111510.1038/s41598-024-55503-wDevelopment of spray-dried powder hand sanitiser with prolonged effectivityLucie Večerková0Lucie Mašková1Zdeněk Knejzlík2Ondřej Kašpar3Viola Tokárová4Department of Chemical Engineering, University of Chemistry and Technology PragueDepartment of Chemical Engineering, University of Chemistry and Technology PragueInstitute of Organic Chemistry and Biochemistry, Czech Academy of SciencesDepartment of Chemical Engineering, University of Chemistry and Technology PragueDepartment of Chemical Engineering, University of Chemistry and Technology PragueAbstract Since the outbreak of the COVID-19 pandemic, the use of hand sanitisers has become an inseparable part of our personal hygiene. However, the short-term effect and the need for frequent application are shortcomings that impair the overall protection. Another aspect is that repeated use of some products (typically alcohol-based) may cause skin irritation or eventually more severe health problems. This work proposes spray-drying as a suitable method for the preparation of swellable chitosan carriers, allowing for encapsulation and sustained release of antibacterial chlorhexidine digluconate as a model active substance. After application to hands, micron-sized particles preferentially accommodate space between epidermal ridges, protected against attrition. Thanks to their small size (d < 10 µm), particles are comfortable to carry since they are not recognisable by somatosensory receptors. The performance of formulations with various amounts of chlorhexidine and cross-linker was tested and compared with selected commercial disinfectants available on the Czech market (ethanol gel and alcoholic solution with chlorhexidine) against E. coli and S. epidermidis. The real-life performance was investigated with twelve volunteers performing various activities for up to 2 h. Finally, a replica of the human index finger with accurately captured micro-topology was proposed and compared with volunteers’ fingers concerning the total amount of adhered and detached particles.https://doi.org/10.1038/s41598-024-55503-w |
| spellingShingle | Lucie Večerková Lucie Mašková Zdeněk Knejzlík Ondřej Kašpar Viola Tokárová Development of spray-dried powder hand sanitiser with prolonged effectivity Scientific Reports |
| title | Development of spray-dried powder hand sanitiser with prolonged effectivity |
| title_full | Development of spray-dried powder hand sanitiser with prolonged effectivity |
| title_fullStr | Development of spray-dried powder hand sanitiser with prolonged effectivity |
| title_full_unstemmed | Development of spray-dried powder hand sanitiser with prolonged effectivity |
| title_short | Development of spray-dried powder hand sanitiser with prolonged effectivity |
| title_sort | development of spray dried powder hand sanitiser with prolonged effectivity |
| url | https://doi.org/10.1038/s41598-024-55503-w |
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