In vitro treatment of 3 T3-L1 adipocytes with recombinant Calcium/calmodulin-dependent Protein Kinase IV (CaMKIV) limits ER stress and improves insulin sensitivity through inhibition of autophagy via the mTOR/CREB signaling pathway

In vitro treatment of 3 T3-L1 adipocytes with recombinant Calcium/calmodulin-dependent Protein Kinase IV (CaMKIV) limits ER stress and improves insulin sensitivity through inhibition of autophagy via the mTOR/CREB signaling pathway

Abstract Background Recently, CaMKIV has been identified as a potential regulator of skeletal muscle glucose metabolism, it can also affect insulin gene expression in pancreas. However, its effects on adipose insulin resistance have yet to be explored. Autophagy has been shown as a potential therape...

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Bibliographic Details
Main Authors: Jiali Liu, Ruihua Yang, Hao Meng, Ting Zhou, Qian He
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Endocrine Disorders
Subjects:
CaMKIV
Adipose
ER stress
Autophagy
Insulin resistance
Online Access:http://link.springer.com/article/10.1186/s12902-020-00589-2

Internet

http://link.springer.com/article/10.1186/s12902-020-00589-2

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