ACE2 in the Gut: The Center of the 2019-nCoV Infected Pathology
The 2019-nCoV is a rapidly contagious pneumonia caused by the recently discovered coronavirus. Although generally the most noticeable symptoms are concentrated in the lungs, the disorders in the gastrointestinal tract are of great importance in the diagnosis of 2019-nCoV. The angiotensin-converting...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.708336/full |
| _version_ | 1817979090680938496 |
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| author | Yuexin Guo Boya Wang Han Gao Lei Gao Rongxuan Hua Jing-Dong Xu |
| author_facet | Yuexin Guo Boya Wang Han Gao Lei Gao Rongxuan Hua Jing-Dong Xu |
| author_sort | Yuexin Guo |
| collection | DOAJ |
| description | The 2019-nCoV is a rapidly contagious pneumonia caused by the recently discovered coronavirus. Although generally the most noticeable symptoms are concentrated in the lungs, the disorders in the gastrointestinal tract are of great importance in the diagnosis of 2019-nCoV. The angiotensin-converting enzyme 2 (ACE2), an important regulator of many physiological functions, including blood pressure and nutrients absorption, is recently identified as a vital entry for 2019-nCoV to enter host cells. In this review, we summarize its functions both physiologically and pathologically. We also elaborate its conflicting roles from the clews of contemporary researches, which may provide significant indications for pharmacological investigations and clinical uses. |
| first_indexed | 2024-04-13T22:37:23Z |
| format | Article |
| id | doaj.art-ab6ee399fd9e476d9609813f686839bb |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-13T22:37:23Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-ab6ee399fd9e476d9609813f686839bb2022-12-22T02:26:43ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-09-01810.3389/fmolb.2021.708336708336ACE2 in the Gut: The Center of the 2019-nCoV Infected PathologyYuexin Guo0Boya Wang1Han Gao2Lei Gao3Rongxuan Hua4Jing-Dong Xu5Department of Oral Medicine, School of Basic Medical Sciences, Capital Medical University, Beijing, ChinaUndergraduate Student of 2018 Eight Program of Clinical Medicine, Peking University Health Science Center, Beijing, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, ChinaDepartment of Bioinformatics, School of Biomedical Engineering, Capital Medical University, Beijing, ChinaDepartment of Clinical Medicine, School of Basic Medical Sciences, Capital Medical University, Beijing, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, ChinaThe 2019-nCoV is a rapidly contagious pneumonia caused by the recently discovered coronavirus. Although generally the most noticeable symptoms are concentrated in the lungs, the disorders in the gastrointestinal tract are of great importance in the diagnosis of 2019-nCoV. The angiotensin-converting enzyme 2 (ACE2), an important regulator of many physiological functions, including blood pressure and nutrients absorption, is recently identified as a vital entry for 2019-nCoV to enter host cells. In this review, we summarize its functions both physiologically and pathologically. We also elaborate its conflicting roles from the clews of contemporary researches, which may provide significant indications for pharmacological investigations and clinical uses.https://www.frontiersin.org/articles/10.3389/fmolb.2021.708336/fullACE22019-nCoVgutfunctionbiological actions |
| spellingShingle | Yuexin Guo Boya Wang Han Gao Lei Gao Rongxuan Hua Jing-Dong Xu ACE2 in the Gut: The Center of the 2019-nCoV Infected Pathology Frontiers in Molecular Biosciences ACE2 2019-nCoV gut function biological actions |
| title | ACE2 in the Gut: The Center of the 2019-nCoV Infected Pathology |
| title_full | ACE2 in the Gut: The Center of the 2019-nCoV Infected Pathology |
| title_fullStr | ACE2 in the Gut: The Center of the 2019-nCoV Infected Pathology |
| title_full_unstemmed | ACE2 in the Gut: The Center of the 2019-nCoV Infected Pathology |
| title_short | ACE2 in the Gut: The Center of the 2019-nCoV Infected Pathology |
| title_sort | ace2 in the gut the center of the 2019 ncov infected pathology |
| topic | ACE2 2019-nCoV gut function biological actions |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.708336/full |
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