Thyroid dysfunction in young, first-episode and drug-naïve patients with major depressive disorder: prevalence and associated clinical factors
ObjectiveThe incidence of thyroid dysfunction (TD) and major depressive disorder (MDD) is increasing year by year in the general population. However, the prevalence and correlates of TD in first-episode drug-naive (FEDN) MDD patients have not been explored. This study sought to fill this gap and exa...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1156481/full |
| _version_ | 1797791117722255360 |
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| author | Jinbo Wu Zhunian Wang Hongjiao Xu Liying Yang Jiacheng Liu Yue Zheng Chuanyi Kang Xiaohong Wang Jingjing Shi Na Zhao Xiang Yang Zhang |
| author_facet | Jinbo Wu Zhunian Wang Hongjiao Xu Liying Yang Jiacheng Liu Yue Zheng Chuanyi Kang Xiaohong Wang Jingjing Shi Na Zhao Xiang Yang Zhang |
| author_sort | Jinbo Wu |
| collection | DOAJ |
| description | ObjectiveThe incidence of thyroid dysfunction (TD) and major depressive disorder (MDD) is increasing year by year in the general population. However, the prevalence and correlates of TD in first-episode drug-naive (FEDN) MDD patients have not been explored. This study sought to fill this gap and examine the association between TD and MDD.MethodsWe recruited 1,289 FEDN MDD patients aged 18 ~ 45 years. A total of 1,289 FEDN MDD outpatients were recruited. Demographical and suicide data were collected for each patient, and lipid profiles, thyroid function, and fasting blood glucose (FBG) levels were measured. The Hamilton Depression Scale 17 (HAMD-17) was assessed for depression.ResultsThe prevalence of TD in young FEDN MDD patients was 64.86%. Compared with those without TD, patients with TD had longer duration of illness, greater HAMD score, higher BMI, TG, TC, and LDL-C levels, and higher suicide attempt rates, but lower HDL-C and FBG levels. Further logistic regression indicated that duration of illness, HAMD score, TC, HDL-C, BMI, and FBG levels were significantly associated with TD.LimitationsNo causal relationship can be drawn due to the cross-sectional design.ConclusionTD is common in young FEDN MDD patients. So clinicians should monitor thyroid function in patients with MDD. |
| first_indexed | 2024-03-13T02:14:15Z |
| format | Article |
| id | doaj.art-ab6f1b3d01834afc89ac0e3493a09d27 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-13T02:14:15Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-ab6f1b3d01834afc89ac0e3493a09d272023-06-30T18:15:34ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-06-011410.3389/fpsyt.2023.11564811156481Thyroid dysfunction in young, first-episode and drug-naïve patients with major depressive disorder: prevalence and associated clinical factorsJinbo Wu0Zhunian Wang1Hongjiao Xu2Liying Yang3Jiacheng Liu4Yue Zheng5Chuanyi Kang6Xiaohong Wang7Jingjing Shi8Na Zhao9Xiang Yang Zhang10First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, ChinaQingdao Mental Health Center, Qingdao, ChinaQingdao Mental Health Center, Qingdao, ChinaDalian No.7 People's Hospital, Dalian, Liaoning Province, ChinaFirst Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, ChinaPeking University Sixth Hospital, Beijing, ChinaFirst Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, ChinaFirst Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, ChinaFirst Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, ChinaFirst Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, ChinaCAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, ChinaObjectiveThe incidence of thyroid dysfunction (TD) and major depressive disorder (MDD) is increasing year by year in the general population. However, the prevalence and correlates of TD in first-episode drug-naive (FEDN) MDD patients have not been explored. This study sought to fill this gap and examine the association between TD and MDD.MethodsWe recruited 1,289 FEDN MDD patients aged 18 ~ 45 years. A total of 1,289 FEDN MDD outpatients were recruited. Demographical and suicide data were collected for each patient, and lipid profiles, thyroid function, and fasting blood glucose (FBG) levels were measured. The Hamilton Depression Scale 17 (HAMD-17) was assessed for depression.ResultsThe prevalence of TD in young FEDN MDD patients was 64.86%. Compared with those without TD, patients with TD had longer duration of illness, greater HAMD score, higher BMI, TG, TC, and LDL-C levels, and higher suicide attempt rates, but lower HDL-C and FBG levels. Further logistic regression indicated that duration of illness, HAMD score, TC, HDL-C, BMI, and FBG levels were significantly associated with TD.LimitationsNo causal relationship can be drawn due to the cross-sectional design.ConclusionTD is common in young FEDN MDD patients. So clinicians should monitor thyroid function in patients with MDD.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1156481/fullmajor depressive disorderprevalenceassociationmetabolizethyroid dysfunction |
| spellingShingle | Jinbo Wu Zhunian Wang Hongjiao Xu Liying Yang Jiacheng Liu Yue Zheng Chuanyi Kang Xiaohong Wang Jingjing Shi Na Zhao Xiang Yang Zhang Thyroid dysfunction in young, first-episode and drug-naïve patients with major depressive disorder: prevalence and associated clinical factors Frontiers in Psychiatry major depressive disorder prevalence association metabolize thyroid dysfunction |
| title | Thyroid dysfunction in young, first-episode and drug-naïve patients with major depressive disorder: prevalence and associated clinical factors |
| title_full | Thyroid dysfunction in young, first-episode and drug-naïve patients with major depressive disorder: prevalence and associated clinical factors |
| title_fullStr | Thyroid dysfunction in young, first-episode and drug-naïve patients with major depressive disorder: prevalence and associated clinical factors |
| title_full_unstemmed | Thyroid dysfunction in young, first-episode and drug-naïve patients with major depressive disorder: prevalence and associated clinical factors |
| title_short | Thyroid dysfunction in young, first-episode and drug-naïve patients with major depressive disorder: prevalence and associated clinical factors |
| title_sort | thyroid dysfunction in young first episode and drug naive patients with major depressive disorder prevalence and associated clinical factors |
| topic | major depressive disorder prevalence association metabolize thyroid dysfunction |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1156481/full |
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