Perspectives on Vascular Regulation of Mechanisms Controlling Selective Immune Cell Function in the Tumor Immune Response
The vasculature plays a major role in regulating the tumor immune cell response although the underlying mechanisms explaining such effects remain poorly understood. This review discusses current knowledge on known vascular functions with a viewpoint on how they may yield distinct immune responses. T...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/4/2313 |
| _version_ | 1797479260992045056 |
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| author | Michael Welsh |
| author_facet | Michael Welsh |
| author_sort | Michael Welsh |
| collection | DOAJ |
| description | The vasculature plays a major role in regulating the tumor immune cell response although the underlying mechanisms explaining such effects remain poorly understood. This review discusses current knowledge on known vascular functions with a viewpoint on how they may yield distinct immune responses. The vasculature might directly influence selective immune cell infiltration into tumors by its cell surface expression of cell adhesion molecules, expression of cytokines, cell junction properties, focal adhesions, cytoskeleton and functional capacity. This will alter the tumor microenvironment and unleash a plethora of responses that will influence the tumor’s immune status. Despite our current knowledge of numerous mechanisms operating, the field is underexplored in that few functions providing a high degree of specificity have yet been provided in relation to the enormous divergence of responses apparent in human cancers. Further exploration of this field is much warranted. |
| first_indexed | 2024-03-09T21:44:16Z |
| format | Article |
| id | doaj.art-ab6fd20e057340d0a97b7029133a74d7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:44:16Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ab6fd20e057340d0a97b7029133a74d72023-11-23T20:23:28ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-02-01234231310.3390/ijms23042313Perspectives on Vascular Regulation of Mechanisms Controlling Selective Immune Cell Function in the Tumor Immune ResponseMichael Welsh0Department of Medical Cell Biology, Uppsala University, Husargatan 3, Box 571, SE-75123 Uppsala, SwedenThe vasculature plays a major role in regulating the tumor immune cell response although the underlying mechanisms explaining such effects remain poorly understood. This review discusses current knowledge on known vascular functions with a viewpoint on how they may yield distinct immune responses. The vasculature might directly influence selective immune cell infiltration into tumors by its cell surface expression of cell adhesion molecules, expression of cytokines, cell junction properties, focal adhesions, cytoskeleton and functional capacity. This will alter the tumor microenvironment and unleash a plethora of responses that will influence the tumor’s immune status. Despite our current knowledge of numerous mechanisms operating, the field is underexplored in that few functions providing a high degree of specificity have yet been provided in relation to the enormous divergence of responses apparent in human cancers. Further exploration of this field is much warranted.https://www.mdpi.com/1422-0067/23/4/2313vasculatureimmune cellstumorscytokinescell adhesion moleculesleakage |
| spellingShingle | Michael Welsh Perspectives on Vascular Regulation of Mechanisms Controlling Selective Immune Cell Function in the Tumor Immune Response International Journal of Molecular Sciences vasculature immune cells tumors cytokines cell adhesion molecules leakage |
| title | Perspectives on Vascular Regulation of Mechanisms Controlling Selective Immune Cell Function in the Tumor Immune Response |
| title_full | Perspectives on Vascular Regulation of Mechanisms Controlling Selective Immune Cell Function in the Tumor Immune Response |
| title_fullStr | Perspectives on Vascular Regulation of Mechanisms Controlling Selective Immune Cell Function in the Tumor Immune Response |
| title_full_unstemmed | Perspectives on Vascular Regulation of Mechanisms Controlling Selective Immune Cell Function in the Tumor Immune Response |
| title_short | Perspectives on Vascular Regulation of Mechanisms Controlling Selective Immune Cell Function in the Tumor Immune Response |
| title_sort | perspectives on vascular regulation of mechanisms controlling selective immune cell function in the tumor immune response |
| topic | vasculature immune cells tumors cytokines cell adhesion molecules leakage |
| url | https://www.mdpi.com/1422-0067/23/4/2313 |
| work_keys_str_mv | AT michaelwelsh perspectivesonvascularregulationofmechanismscontrollingselectiveimmunecellfunctioninthetumorimmuneresponse |