MDL-28170 Has No Analgesic Effect on CCI Induced Neuropathic Pain in Mice

MDL-28170 Has No Analgesic Effect on CCI Induced Neuropathic Pain in Mice

The calpain inhibitor MDL-28710 blocks the early local pro-inflammatory cytokine gene expression in mice after chronic constriction nerve injury (CCI). One-hundred-thirteen wild type mice of C57Bl/6J background received CCI of the right sciatic nerve. Mechanical paw withdrawal thresholds and thermal...

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Bibliographic Details
Main Authors: Claudia Sommer, Lydia Biko, Nurcan Üçeyler
Format: Article
Language:English
Published: MDPI AG 2010-04-01
Series:Molecules
Subjects:
calpain
neuropathic pain
MDL-28170
chronic constriction nerve injury (CCI)
Online Access:http://www.mdpi.com/1420-3049/15/5/3038/

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