REGULATORY T-CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA
Regulatory T-cells (Tregs) constitute a small subset of cells that are actively involved in maintaining self-tolerance, in immune homeostasis and in antitumor immunity. They are thought to play a significant role in the progression of cancer and are generally increased in patient with chronic lympho...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2014-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1680 |
| _version_ | 1826908808900771840 |
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| author | Giovanni D'Arena Giovanni Rossi Barbara Vannata Silvia Deaglio |
| author_facet | Giovanni D'Arena Giovanni Rossi Barbara Vannata Silvia Deaglio |
| author_sort | Giovanni D'Arena |
| collection | DOAJ |
| description | Regulatory T-cells (Tregs) constitute a small subset of cells that are actively involved in maintaining self-tolerance, in immune homeostasis and in antitumor immunity. They are thought to play a significant role in the progression of cancer and are generally increased in patient with chronic lymphocytic leukemia (CLL). Their number correlates with more aggressive disease status and is predictive of the time to treatment, as well. Moreover, it is now clear that dysregulation in Tregs cell frequency and/or function may result in a plethora of autoimmune diseases, including multiple sclerosis, type 1 diabetes mellitus, myasthenia gravis, systemic lupus erythematosis, autoimmune lymphoproliferative disorders, rheumatoid arthritis, and psoriasis. Efforts are made aiming to develop approaches to deplete Tregs or inhibit their function in either cancer and autoimmune disorders. |
| first_indexed | 2024-12-19T16:31:00Z |
| format | Article |
| id | doaj.art-ab726cf4de894ff0b40ee4635312faf3 |
| institution | Directory Open Access Journal |
| issn | 2035-3006 |
| language | English |
| last_indexed | 2025-02-17T09:30:52Z |
| publishDate | 2014-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj.art-ab726cf4de894ff0b40ee4635312faf32025-01-02T10:51:28ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062014-08-011REGULATORY T-CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIAGiovanni D'Arena0Giovanni Rossi1Barbara VannataSilvia DeaglioDepartment of Onco-Hematology, IRCCS “Centro di Riferimento Oncologico della Basilicata”, Via Padre Pio n. 1, 85028 Rionero in Vulture (Pz), Italy Phone: +39.0972.726521 FAX: +39.0972.726217),(2),(3),(4), Giovanna Mansueto (1), Fiorella D’Auria (5), Teodora Statuto (5), Vittorio Simeon (6), Laura De Martino (7), Aurelio Marandino (7), Giovanni Del Poeta (8), Vincenzo De Feo (7), Pellegrino Musto (1)Regulatory T-cells (Tregs) constitute a small subset of cells that are actively involved in maintaining self-tolerance, in immune homeostasis and in antitumor immunity. They are thought to play a significant role in the progression of cancer and are generally increased in patient with chronic lymphocytic leukemia (CLL). Their number correlates with more aggressive disease status and is predictive of the time to treatment, as well. Moreover, it is now clear that dysregulation in Tregs cell frequency and/or function may result in a plethora of autoimmune diseases, including multiple sclerosis, type 1 diabetes mellitus, myasthenia gravis, systemic lupus erythematosis, autoimmune lymphoproliferative disorders, rheumatoid arthritis, and psoriasis. Efforts are made aiming to develop approaches to deplete Tregs or inhibit their function in either cancer and autoimmune disorders.https://mjhid.org/index.php/mjhid/article/view/1680 |
| spellingShingle | Giovanni D'Arena Giovanni Rossi Barbara Vannata Silvia Deaglio REGULATORY T-CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA Mediterranean Journal of Hematology and Infectious Diseases |
| title | REGULATORY T-CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA |
| title_full | REGULATORY T-CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA |
| title_fullStr | REGULATORY T-CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA |
| title_full_unstemmed | REGULATORY T-CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA |
| title_short | REGULATORY T-CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA |
| title_sort | regulatory t cells in chronic lymphocytic leukemia |
| url | https://mjhid.org/index.php/mjhid/article/view/1680 |
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