Integrated bioinformatics analysis identifies shared immune changes between ischemic stroke and COVID 19
Although COVID-19 is primarily a respiratory disease, its neurological complications, such as ischemic stroke (IS), have aroused growing concerns and reports. However, the molecular mechanisms that underlie IS and COVID-19 are not well understood. Therefore, we implemented transcriptomic analysis fr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1102281/full |
| _version_ | 1811158396441722880 |
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| author | Wenhao Liu Wenhao Liu Fei Han Mengyao Wan Mengyao Wan Xin-Zhuang Yang |
| author_facet | Wenhao Liu Wenhao Liu Fei Han Mengyao Wan Mengyao Wan Xin-Zhuang Yang |
| author_sort | Wenhao Liu |
| collection | DOAJ |
| description | Although COVID-19 is primarily a respiratory disease, its neurological complications, such as ischemic stroke (IS), have aroused growing concerns and reports. However, the molecular mechanisms that underlie IS and COVID-19 are not well understood. Therefore, we implemented transcriptomic analysis from eight GEO datasets consist of 1191 samples to detect common pathways and molecular biomarkers in IS and COVID-19 that help understand the linkage between them. Differentially expressed genes (DEGs) were detected for IS and COVID-19 separately for finding shared mechanisms and we found that immune-related pathways were outlined with statistical significance. JAK2, which was identified as a hub gene, was supposed to be a potential therapeutic gene targets during the immunological process of COVID-19 and IS. Besides, we found a decrease in the proportion of CD8+ T and T helper 2 cells in the peripheral circulation of both COVID and IS patients, and NCR3 expression was significantly correlated with this change. In conclusion, we demonstrated that transcriptomic analyses reported in this study could make a deeper understanding of the common mechanism and might be promising for effective therapeutic for IS and COVID-19. |
| first_indexed | 2024-04-10T05:22:43Z |
| format | Article |
| id | doaj.art-ab7550da4f44452b9f753284b7075386 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T05:22:43Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ab7550da4f44452b9f753284b70753862023-03-08T05:50:55ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-03-011410.3389/fimmu.2023.11022811102281Integrated bioinformatics analysis identifies shared immune changes between ischemic stroke and COVID 19Wenhao Liu0Wenhao Liu1Fei Han2Mengyao Wan3Mengyao Wan4Xin-Zhuang Yang5Eight-year program of Clinical Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaDepartment of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaEight-year program of Clinical Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaDepartment of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaMedical Research Center, State Key laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaAlthough COVID-19 is primarily a respiratory disease, its neurological complications, such as ischemic stroke (IS), have aroused growing concerns and reports. However, the molecular mechanisms that underlie IS and COVID-19 are not well understood. Therefore, we implemented transcriptomic analysis from eight GEO datasets consist of 1191 samples to detect common pathways and molecular biomarkers in IS and COVID-19 that help understand the linkage between them. Differentially expressed genes (DEGs) were detected for IS and COVID-19 separately for finding shared mechanisms and we found that immune-related pathways were outlined with statistical significance. JAK2, which was identified as a hub gene, was supposed to be a potential therapeutic gene targets during the immunological process of COVID-19 and IS. Besides, we found a decrease in the proportion of CD8+ T and T helper 2 cells in the peripheral circulation of both COVID and IS patients, and NCR3 expression was significantly correlated with this change. In conclusion, we demonstrated that transcriptomic analyses reported in this study could make a deeper understanding of the common mechanism and might be promising for effective therapeutic for IS and COVID-19.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1102281/fullCOVID-19ischemic strokegene expression profilesimmune systemimmune cell proportion |
| spellingShingle | Wenhao Liu Wenhao Liu Fei Han Mengyao Wan Mengyao Wan Xin-Zhuang Yang Integrated bioinformatics analysis identifies shared immune changes between ischemic stroke and COVID 19 Frontiers in Immunology COVID-19 ischemic stroke gene expression profiles immune system immune cell proportion |
| title | Integrated bioinformatics analysis identifies shared immune changes between ischemic stroke and COVID 19 |
| title_full | Integrated bioinformatics analysis identifies shared immune changes between ischemic stroke and COVID 19 |
| title_fullStr | Integrated bioinformatics analysis identifies shared immune changes between ischemic stroke and COVID 19 |
| title_full_unstemmed | Integrated bioinformatics analysis identifies shared immune changes between ischemic stroke and COVID 19 |
| title_short | Integrated bioinformatics analysis identifies shared immune changes between ischemic stroke and COVID 19 |
| title_sort | integrated bioinformatics analysis identifies shared immune changes between ischemic stroke and covid 19 |
| topic | COVID-19 ischemic stroke gene expression profiles immune system immune cell proportion |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1102281/full |
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