Effect of Sodium Alginate Addition to Resveratrol on Acute Gouty Arthritis
Objective: Resveratrol has been shown to exert anti-inflammatory and antioxidant effects, while sodium alginate is a common pharmaceutic adjuvant with antioxidative and immunomodulatory properties. We performed an animal study to investigate the effect of sodium alginate addition to resveratrol on a...
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| Format: | Article |
| Language: | English |
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Cell Physiol Biochem Press GmbH & Co KG
2015-04-01
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| Series: | Cellular Physiology and Biochemistry |
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| Online Access: | http://www.karger.com/Article/FullText/374064 |
| _version_ | 1818054937300434944 |
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| author | Peng Wang Dunlin Ren Ying Chen Meiju Jiang Robin Wang Yan-Gang Wang |
| author_facet | Peng Wang Dunlin Ren Ying Chen Meiju Jiang Robin Wang Yan-Gang Wang |
| author_sort | Peng Wang |
| collection | DOAJ |
| description | Objective: Resveratrol has been shown to exert anti-inflammatory and antioxidant effects, while sodium alginate is a common pharmaceutic adjuvant with antioxidative and immunomodulatory properties. We performed an animal study to investigate the effect of sodium alginate addition to resveratrol on acute gouty arthritis. Methods: Twenty-four SPF Wistar mice were randomized to four groups receiving the combination of sodium alginate and resveratrol, resveratrol alone, colchicine, and placebo, respectively. Acute gouty arthritis was induced by injection of 0.05 ml monosodium urate (MSU) solution (25g/mL) into ankle joint cavity. IL-1β, CCR5, and CXCL10 levels in both serum and synovial fluid were measured using ELISA. NLRP3 expression in the synovial tissues was measured using western plot. Results: The combination of sodium alginate and resveratrol significantly reduced synovial levels of IL-1β, CCR5, and CXCL10 when compared with colchicines, and all P values were less than 0.0001. The combination of sodium alginate and resveratrol was also superior to resveratrol in terms of both serum levels and synovial levels of IL-1β, CCR5, and CXCL10. In addition, resveratrol, with or without sodium alginate, could reduce NLRP3 expression obviously in the synovial tissues. Conclusion: The combination of sodium alginate and resveratrol has better effect over colchicines in treating MSU-induced acute gouty arthritis. |
| first_indexed | 2024-12-10T12:04:59Z |
| format | Article |
| id | doaj.art-ab78d7e5332e48b681747e827f5162d6 |
| institution | Directory Open Access Journal |
| issn | 1015-8987 1421-9778 |
| language | English |
| last_indexed | 2024-12-10T12:04:59Z |
| publishDate | 2015-04-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
| record_format | Article |
| series | Cellular Physiology and Biochemistry |
| spelling | doaj.art-ab78d7e5332e48b681747e827f5162d62022-12-22T01:49:29ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782015-04-0136120120710.1159/000374064374064Effect of Sodium Alginate Addition to Resveratrol on Acute Gouty ArthritisPeng WangDunlin RenYing ChenMeiju JiangRobin WangYan-Gang WangObjective: Resveratrol has been shown to exert anti-inflammatory and antioxidant effects, while sodium alginate is a common pharmaceutic adjuvant with antioxidative and immunomodulatory properties. We performed an animal study to investigate the effect of sodium alginate addition to resveratrol on acute gouty arthritis. Methods: Twenty-four SPF Wistar mice were randomized to four groups receiving the combination of sodium alginate and resveratrol, resveratrol alone, colchicine, and placebo, respectively. Acute gouty arthritis was induced by injection of 0.05 ml monosodium urate (MSU) solution (25g/mL) into ankle joint cavity. IL-1β, CCR5, and CXCL10 levels in both serum and synovial fluid were measured using ELISA. NLRP3 expression in the synovial tissues was measured using western plot. Results: The combination of sodium alginate and resveratrol significantly reduced synovial levels of IL-1β, CCR5, and CXCL10 when compared with colchicines, and all P values were less than 0.0001. The combination of sodium alginate and resveratrol was also superior to resveratrol in terms of both serum levels and synovial levels of IL-1β, CCR5, and CXCL10. In addition, resveratrol, with or without sodium alginate, could reduce NLRP3 expression obviously in the synovial tissues. Conclusion: The combination of sodium alginate and resveratrol has better effect over colchicines in treating MSU-induced acute gouty arthritis.http://www.karger.com/Article/FullText/374064ResveratrolSodium alginateAcute gouty arthritis |
| spellingShingle | Peng Wang Dunlin Ren Ying Chen Meiju Jiang Robin Wang Yan-Gang Wang Effect of Sodium Alginate Addition to Resveratrol on Acute Gouty Arthritis Cellular Physiology and Biochemistry Resveratrol Sodium alginate Acute gouty arthritis |
| title | Effect of Sodium Alginate Addition to Resveratrol on Acute Gouty Arthritis |
| title_full | Effect of Sodium Alginate Addition to Resveratrol on Acute Gouty Arthritis |
| title_fullStr | Effect of Sodium Alginate Addition to Resveratrol on Acute Gouty Arthritis |
| title_full_unstemmed | Effect of Sodium Alginate Addition to Resveratrol on Acute Gouty Arthritis |
| title_short | Effect of Sodium Alginate Addition to Resveratrol on Acute Gouty Arthritis |
| title_sort | effect of sodium alginate addition to resveratrol on acute gouty arthritis |
| topic | Resveratrol Sodium alginate Acute gouty arthritis |
| url | http://www.karger.com/Article/FullText/374064 |
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