510 Independent and Combined Effectiveness of Multiple Micronutrient Supplementation and Responsive Caregiving Interventions to Support Early Child Development in Southwest Guatemala
OBJECTIVES/GOALS: The objective of this study is to examine the independent and combined effectiveness of a multiple micronutrient supplementation and responsive caregiving intervention on early child development in southwestern Guatemala. METHODS/STUDY POPULATION: We conducted a double blind, 2 x 2...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2022-04-01
|
| Series: | Journal of Clinical and Translational Science |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866122003041/type/journal_article |
| _version_ | 1811155241641443328 |
|---|---|
| author | Alysse Kowalski Maureen Black |
| author_facet | Alysse Kowalski Maureen Black |
| author_sort | Alysse Kowalski |
| collection | DOAJ |
| description | OBJECTIVES/GOALS: The objective of this study is to examine the independent and combined effectiveness of a multiple micronutrient supplementation and responsive caregiving intervention on early child development in southwestern Guatemala. METHODS/STUDY POPULATION: We conducted a double blind, 2 x 2, cluster randomized controlled trial combining micronutrient supplementation and responsive caregiving treatments. We enrolled 309 infants (6-18 months) and 387 preschoolers (36-52 months) at nutritional risk (height-for-age z-score < -1) (51% male; 17% indigenous ethnicity; 76% of caregivers completed ≤ primary school). The supplementation arm received a maize-soy product fortified with 21 micronutrients for 6 months; the control was fortified with B2. The responsive caregiving intervention was adapted from the UNICEF Care for Child Development program and delivered over 6 home visits. We examined changes in early child development from baseline (2015) to endline (2017) using the Bayley Scales of Infant and Toddler Development III and Bracken Scales of School Readiness. RESULTS/ANTICIPATED RESULTS: Among infants, age standardized Bayley cognitive development scores declined over time in each treatment arm. Infant Bayley motor development scores significantly increased in the combined multiple micronutrient supplementation + responsive caregiving arm (â^† = 3.67 [95% CI: 0.17, 7.17], p = 0.04). Among preschoolers, school readiness decreased over time in each treatment arm. The rates of change in infant development and preschooler school readiness did not differ between treatment arms. Further analysis will explore effect modification of the intervention by pre-specified child and household factors. DISCUSSION/SIGNIFICANCE: Combined multiple micronutrient supplementation and responsive caregiving supported motor development while cognitive and school readiness were not impacted by the intervention. These findings will inform the effectiveness and beneficiaries of multisectoral interventions to promote early child development in adverse environments. |
| first_indexed | 2024-04-10T04:30:52Z |
| format | Article |
| id | doaj.art-ab790099371e4c05bdb46008788f562f |
| institution | Directory Open Access Journal |
| issn | 2059-8661 |
| language | English |
| last_indexed | 2024-04-10T04:30:52Z |
| publishDate | 2022-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj.art-ab790099371e4c05bdb46008788f562f2023-03-10T07:53:50ZengCambridge University PressJournal of Clinical and Translational Science2059-86612022-04-01610410410.1017/cts.2022.304510 Independent and Combined Effectiveness of Multiple Micronutrient Supplementation and Responsive Caregiving Interventions to Support Early Child Development in Southwest GuatemalaAlysse Kowalski0Maureen Black1University of Maryland School of MedicineUniversity of Maryland School of MedicineOBJECTIVES/GOALS: The objective of this study is to examine the independent and combined effectiveness of a multiple micronutrient supplementation and responsive caregiving intervention on early child development in southwestern Guatemala. METHODS/STUDY POPULATION: We conducted a double blind, 2 x 2, cluster randomized controlled trial combining micronutrient supplementation and responsive caregiving treatments. We enrolled 309 infants (6-18 months) and 387 preschoolers (36-52 months) at nutritional risk (height-for-age z-score < -1) (51% male; 17% indigenous ethnicity; 76% of caregivers completed ≤ primary school). The supplementation arm received a maize-soy product fortified with 21 micronutrients for 6 months; the control was fortified with B2. The responsive caregiving intervention was adapted from the UNICEF Care for Child Development program and delivered over 6 home visits. We examined changes in early child development from baseline (2015) to endline (2017) using the Bayley Scales of Infant and Toddler Development III and Bracken Scales of School Readiness. RESULTS/ANTICIPATED RESULTS: Among infants, age standardized Bayley cognitive development scores declined over time in each treatment arm. Infant Bayley motor development scores significantly increased in the combined multiple micronutrient supplementation + responsive caregiving arm (â^† = 3.67 [95% CI: 0.17, 7.17], p = 0.04). Among preschoolers, school readiness decreased over time in each treatment arm. The rates of change in infant development and preschooler school readiness did not differ between treatment arms. Further analysis will explore effect modification of the intervention by pre-specified child and household factors. DISCUSSION/SIGNIFICANCE: Combined multiple micronutrient supplementation and responsive caregiving supported motor development while cognitive and school readiness were not impacted by the intervention. These findings will inform the effectiveness and beneficiaries of multisectoral interventions to promote early child development in adverse environments.https://www.cambridge.org/core/product/identifier/S2059866122003041/type/journal_article |
| spellingShingle | Alysse Kowalski Maureen Black 510 Independent and Combined Effectiveness of Multiple Micronutrient Supplementation and Responsive Caregiving Interventions to Support Early Child Development in Southwest Guatemala Journal of Clinical and Translational Science |
| title | 510 Independent and Combined Effectiveness of Multiple Micronutrient Supplementation and Responsive Caregiving Interventions to Support Early Child Development in Southwest Guatemala |
| title_full | 510 Independent and Combined Effectiveness of Multiple Micronutrient Supplementation and Responsive Caregiving Interventions to Support Early Child Development in Southwest Guatemala |
| title_fullStr | 510 Independent and Combined Effectiveness of Multiple Micronutrient Supplementation and Responsive Caregiving Interventions to Support Early Child Development in Southwest Guatemala |
| title_full_unstemmed | 510 Independent and Combined Effectiveness of Multiple Micronutrient Supplementation and Responsive Caregiving Interventions to Support Early Child Development in Southwest Guatemala |
| title_short | 510 Independent and Combined Effectiveness of Multiple Micronutrient Supplementation and Responsive Caregiving Interventions to Support Early Child Development in Southwest Guatemala |
| title_sort | 510 independent and combined effectiveness of multiple micronutrient supplementation and responsive caregiving interventions to support early child development in southwest guatemala |
| url | https://www.cambridge.org/core/product/identifier/S2059866122003041/type/journal_article |
| work_keys_str_mv | AT alyssekowalski 510independentandcombinedeffectivenessofmultiplemicronutrientsupplementationandresponsivecaregivinginterventionstosupportearlychilddevelopmentinsouthwestguatemala AT maureenblack 510independentandcombinedeffectivenessofmultiplemicronutrientsupplementationandresponsivecaregivinginterventionstosupportearlychilddevelopmentinsouthwestguatemala |