The Diverse Roles of Heme Oxygenase-1 in Tumor Progression
Heme oxygenase-1 (HO-1) is an inducible intracellular enzyme that is expressed in response to a variety of stimuli to degrade heme, which generates the biologically active catabolites carbon monoxide (CO), biliverdin and ferrous iron (Fe2+). HO-1 is expressed across a range of cancers and has been d...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.658315/full |
| _version_ | 1828890281262448640 |
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| author | Kim Ngan Luu Hoang Joanne E. Anstee James N. Arnold |
| author_facet | Kim Ngan Luu Hoang Joanne E. Anstee James N. Arnold |
| author_sort | Kim Ngan Luu Hoang |
| collection | DOAJ |
| description | Heme oxygenase-1 (HO-1) is an inducible intracellular enzyme that is expressed in response to a variety of stimuli to degrade heme, which generates the biologically active catabolites carbon monoxide (CO), biliverdin and ferrous iron (Fe2+). HO-1 is expressed across a range of cancers and has been demonstrated to promote tumor progression through a variety of mechanisms. HO-1 can be expressed in a variety of cells within the tumor microenvironment (TME), including both the malignant tumor cells as well as stromal cell populations such as macrophages, dendritic cells and regulatory T-cells. Intrinsically to the cell, HO-1 activity provides antioxidant, anti-apoptotic and cytoprotective effects via its catabolites as well as clearing toxic intracellular heme. However, the catabolites of heme degradation can also diffuse outside of the cell to extrinsically modulate the wider TME, influencing cellular functionality and biological processes which promote tumor progression, such as facilitating angiogenesis and metastasis, as well as promoting anti-inflammation and immune suppression. Pharmacological inhibition of HO-1 has been demonstrated to be a promising therapeutic approach to promote anti-tumor immune responses and inhibit metastasis. However, these biological functions might be context, TME and cell type-dependent as there is also conflicting reports for HO-1 activity facilitating anti-tumoral processes. This review will consider our current understanding of the role of HO-1 in cancer progression and as a therapeutic target in cancer. |
| first_indexed | 2024-12-13T12:56:03Z |
| format | Article |
| id | doaj.art-ab7ce2ce6c664c9f8e4d69a2cd82df45 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T12:56:03Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ab7ce2ce6c664c9f8e4d69a2cd82df452022-12-21T23:45:11ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-03-011210.3389/fimmu.2021.658315658315The Diverse Roles of Heme Oxygenase-1 in Tumor ProgressionKim Ngan Luu HoangJoanne E. AnsteeJames N. ArnoldHeme oxygenase-1 (HO-1) is an inducible intracellular enzyme that is expressed in response to a variety of stimuli to degrade heme, which generates the biologically active catabolites carbon monoxide (CO), biliverdin and ferrous iron (Fe2+). HO-1 is expressed across a range of cancers and has been demonstrated to promote tumor progression through a variety of mechanisms. HO-1 can be expressed in a variety of cells within the tumor microenvironment (TME), including both the malignant tumor cells as well as stromal cell populations such as macrophages, dendritic cells and regulatory T-cells. Intrinsically to the cell, HO-1 activity provides antioxidant, anti-apoptotic and cytoprotective effects via its catabolites as well as clearing toxic intracellular heme. However, the catabolites of heme degradation can also diffuse outside of the cell to extrinsically modulate the wider TME, influencing cellular functionality and biological processes which promote tumor progression, such as facilitating angiogenesis and metastasis, as well as promoting anti-inflammation and immune suppression. Pharmacological inhibition of HO-1 has been demonstrated to be a promising therapeutic approach to promote anti-tumor immune responses and inhibit metastasis. However, these biological functions might be context, TME and cell type-dependent as there is also conflicting reports for HO-1 activity facilitating anti-tumoral processes. This review will consider our current understanding of the role of HO-1 in cancer progression and as a therapeutic target in cancer.https://www.frontiersin.org/articles/10.3389/fimmu.2021.658315/fullheme oxygenase-1 (HO-1)cancercytoprotectiontumor immunologyangiogenesistumor associated macrophages (TAMs) |
| spellingShingle | Kim Ngan Luu Hoang Joanne E. Anstee James N. Arnold The Diverse Roles of Heme Oxygenase-1 in Tumor Progression Frontiers in Immunology heme oxygenase-1 (HO-1) cancer cytoprotection tumor immunology angiogenesis tumor associated macrophages (TAMs) |
| title | The Diverse Roles of Heme Oxygenase-1 in Tumor Progression |
| title_full | The Diverse Roles of Heme Oxygenase-1 in Tumor Progression |
| title_fullStr | The Diverse Roles of Heme Oxygenase-1 in Tumor Progression |
| title_full_unstemmed | The Diverse Roles of Heme Oxygenase-1 in Tumor Progression |
| title_short | The Diverse Roles of Heme Oxygenase-1 in Tumor Progression |
| title_sort | diverse roles of heme oxygenase 1 in tumor progression |
| topic | heme oxygenase-1 (HO-1) cancer cytoprotection tumor immunology angiogenesis tumor associated macrophages (TAMs) |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.658315/full |
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