Current Methods for Identifying Plasma Membrane Proteins as Cancer Biomarkers
Plasma membrane proteins are a special class of biomolecules present on the cellular membrane. They provide the transport of ions, small molecules, and water in response to internal and external signals, define a cell’s immunological identity, and facilitate intra- and intercellular communication. S...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Membranes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0375/13/4/409 |
| _version_ | 1797604399412936704 |
|---|---|
| author | Edwin de Jong Armagan Kocer |
| author_facet | Edwin de Jong Armagan Kocer |
| author_sort | Edwin de Jong |
| collection | DOAJ |
| description | Plasma membrane proteins are a special class of biomolecules present on the cellular membrane. They provide the transport of ions, small molecules, and water in response to internal and external signals, define a cell’s immunological identity, and facilitate intra- and intercellular communication. Since they are vital to almost all cellular functions, their mutants, or aberrant expression is linked to many diseases, including cancer, where they are a part of cancer cell-specific molecular signatures and phenotypes. In addition, their surface-exposed domains make them exciting biomarkers for targeting by imaging agents and drugs. This review looks at the challenges in identifying cancer-related cell membrane proteins and the current methodologies that solve most of the challenges. We classified the methodologies as biased, i.e., search cells for the presence of already known membrane proteins. Second, we discuss the unbiased methods that can identify proteins without prior knowledge of what they are. Finally, we discuss the potential impact of membrane proteins on the early detection and treatment of cancer. |
| first_indexed | 2024-03-11T04:45:54Z |
| format | Article |
| id | doaj.art-ab7cfda3572e4484afded4d0c1b6ce5f |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-11T04:45:54Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-ab7cfda3572e4484afded4d0c1b6ce5f2023-11-17T20:23:11ZengMDPI AGMembranes2077-03752023-04-0113440910.3390/membranes13040409Current Methods for Identifying Plasma Membrane Proteins as Cancer BiomarkersEdwin de Jong0Armagan Kocer1Department of Bioelectric Signaling and Engineering, Faculty of Science and Technology, University of Twente, 7500 AE Enschede, The NetherlandsDepartment of Bioelectric Signaling and Engineering, Faculty of Science and Technology, University of Twente, 7500 AE Enschede, The NetherlandsPlasma membrane proteins are a special class of biomolecules present on the cellular membrane. They provide the transport of ions, small molecules, and water in response to internal and external signals, define a cell’s immunological identity, and facilitate intra- and intercellular communication. Since they are vital to almost all cellular functions, their mutants, or aberrant expression is linked to many diseases, including cancer, where they are a part of cancer cell-specific molecular signatures and phenotypes. In addition, their surface-exposed domains make them exciting biomarkers for targeting by imaging agents and drugs. This review looks at the challenges in identifying cancer-related cell membrane proteins and the current methodologies that solve most of the challenges. We classified the methodologies as biased, i.e., search cells for the presence of already known membrane proteins. Second, we discuss the unbiased methods that can identify proteins without prior knowledge of what they are. Finally, we discuss the potential impact of membrane proteins on the early detection and treatment of cancer.https://www.mdpi.com/2077-0375/13/4/409biomarkerscancermembrane proteinscell surface profilingtumor markers |
| spellingShingle | Edwin de Jong Armagan Kocer Current Methods for Identifying Plasma Membrane Proteins as Cancer Biomarkers Membranes biomarkers cancer membrane proteins cell surface profiling tumor markers |
| title | Current Methods for Identifying Plasma Membrane Proteins as Cancer Biomarkers |
| title_full | Current Methods for Identifying Plasma Membrane Proteins as Cancer Biomarkers |
| title_fullStr | Current Methods for Identifying Plasma Membrane Proteins as Cancer Biomarkers |
| title_full_unstemmed | Current Methods for Identifying Plasma Membrane Proteins as Cancer Biomarkers |
| title_short | Current Methods for Identifying Plasma Membrane Proteins as Cancer Biomarkers |
| title_sort | current methods for identifying plasma membrane proteins as cancer biomarkers |
| topic | biomarkers cancer membrane proteins cell surface profiling tumor markers |
| url | https://www.mdpi.com/2077-0375/13/4/409 |
| work_keys_str_mv | AT edwindejong currentmethodsforidentifyingplasmamembraneproteinsascancerbiomarkers AT armagankocer currentmethodsforidentifyingplasmamembraneproteinsascancerbiomarkers |