The associations between retinol binding protein-4 and cardiometabolic profile: Intertwined-intricate relationship
Retinol binding protein-4 (RBP4) is a new adipokine synthesized by the liver and adipose tissue, and its secretion depends on retinol concentrations and reflects visceral fat mass. RBP4 serum levels are regarded as a new biomarker in follow-up and diagnosis of overweight and obesity and other cardio...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Biomedical and Biotechnology Research Journal |
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| Online Access: | http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2020;volume=4;issue=2;spage=95;epage=107;aulast=Naji |
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| author | Marwa Thaier Naji Oula Mohamed Sami Hala Aqeel Shams May Hassan Abdul-Hadi Hayder Mutter Al-Kuraishy Ali Ismail Al-Gareeb Naseer Abdul-Amer Al-Harchan |
| author_facet | Marwa Thaier Naji Oula Mohamed Sami Hala Aqeel Shams May Hassan Abdul-Hadi Hayder Mutter Al-Kuraishy Ali Ismail Al-Gareeb Naseer Abdul-Amer Al-Harchan |
| author_sort | Marwa Thaier Naji |
| collection | DOAJ |
| description | Retinol binding protein-4 (RBP4) is a new adipokine synthesized by the liver and adipose tissue, and its secretion depends on retinol concentrations and reflects visceral fat mass. RBP4 serum levels are regarded as a new biomarker in follow-up and diagnosis of overweight and obesity and other cardiometabolic disorders, such as hypertension, ischemic stroke, and dyslipidemia. Different drugs such as statins, fibrates, glucagon-like peptide 1 (GLP-1), dipeptidyl peptidase-IV (DPPIV) inhibitors, and thiazolidinediones (TZDs) have been reported to reduce RBP4 levels. The objectives of the present study were to illustrate the role of RBP4 in different cardiometabolic disorders and to explore the conflicting about the effect of different drug groups on the circulating RBP4 levels. A multiplicity of search strategies took on and assumed which included electronic database searches of Scopus, Web of Science, Medline, Cochrane Central Register of Controlled Trials, and PubMed using MeSH terms, keywords, and title words during the search. RBP4 plasma levels are mainly correlated with visceral adiposity and less to the subcutaneous adipose tissue. Statins may reduce or increase RBP4 plasma levels. Fibrate drugs, TZDs, DPPIV inhibitors, and GLP-1 agonists reduce RBP4 plasma levels through suppression of adipose tissue RBP4 mRNA and elevation of adiponectin levels. Metformin reduces circulating RBP4 levels through the improvement of insulin sensitivity, upregulation of glucose transporter 4 (GLUT4), and activation of adipocytes PPARα. |
| first_indexed | 2024-12-14T08:48:41Z |
| format | Article |
| id | doaj.art-ab7d6cd57e814f68b81dde9474c861c7 |
| institution | Directory Open Access Journal |
| issn | 2588-9834 2588-9842 |
| language | English |
| last_indexed | 2024-12-14T08:48:41Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Biomedical and Biotechnology Research Journal |
| spelling | doaj.art-ab7d6cd57e814f68b81dde9474c861c72022-12-21T23:09:06ZengWolters Kluwer Medknow PublicationsBiomedical and Biotechnology Research Journal2588-98342588-98422020-01-01429510710.4103/bbrj.bbrj_6_20The associations between retinol binding protein-4 and cardiometabolic profile: Intertwined-intricate relationshipMarwa Thaier NajiOula Mohamed SamiHala Aqeel ShamsMay Hassan Abdul-HadiHayder Mutter Al-KuraishyAli Ismail Al-GareebNaseer Abdul-Amer Al-HarchanRetinol binding protein-4 (RBP4) is a new adipokine synthesized by the liver and adipose tissue, and its secretion depends on retinol concentrations and reflects visceral fat mass. RBP4 serum levels are regarded as a new biomarker in follow-up and diagnosis of overweight and obesity and other cardiometabolic disorders, such as hypertension, ischemic stroke, and dyslipidemia. Different drugs such as statins, fibrates, glucagon-like peptide 1 (GLP-1), dipeptidyl peptidase-IV (DPPIV) inhibitors, and thiazolidinediones (TZDs) have been reported to reduce RBP4 levels. The objectives of the present study were to illustrate the role of RBP4 in different cardiometabolic disorders and to explore the conflicting about the effect of different drug groups on the circulating RBP4 levels. A multiplicity of search strategies took on and assumed which included electronic database searches of Scopus, Web of Science, Medline, Cochrane Central Register of Controlled Trials, and PubMed using MeSH terms, keywords, and title words during the search. RBP4 plasma levels are mainly correlated with visceral adiposity and less to the subcutaneous adipose tissue. Statins may reduce or increase RBP4 plasma levels. Fibrate drugs, TZDs, DPPIV inhibitors, and GLP-1 agonists reduce RBP4 plasma levels through suppression of adipose tissue RBP4 mRNA and elevation of adiponectin levels. Metformin reduces circulating RBP4 levels through the improvement of insulin sensitivity, upregulation of glucose transporter 4 (GLUT4), and activation of adipocytes PPARα.http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2020;volume=4;issue=2;spage=95;epage=107;aulast=Najicardiometabolic disordersfibrate drugsinsulin sensitivityretinol binding protein-4statins |
| spellingShingle | Marwa Thaier Naji Oula Mohamed Sami Hala Aqeel Shams May Hassan Abdul-Hadi Hayder Mutter Al-Kuraishy Ali Ismail Al-Gareeb Naseer Abdul-Amer Al-Harchan The associations between retinol binding protein-4 and cardiometabolic profile: Intertwined-intricate relationship Biomedical and Biotechnology Research Journal cardiometabolic disorders fibrate drugs insulin sensitivity retinol binding protein-4 statins |
| title | The associations between retinol binding protein-4 and cardiometabolic profile: Intertwined-intricate relationship |
| title_full | The associations between retinol binding protein-4 and cardiometabolic profile: Intertwined-intricate relationship |
| title_fullStr | The associations between retinol binding protein-4 and cardiometabolic profile: Intertwined-intricate relationship |
| title_full_unstemmed | The associations between retinol binding protein-4 and cardiometabolic profile: Intertwined-intricate relationship |
| title_short | The associations between retinol binding protein-4 and cardiometabolic profile: Intertwined-intricate relationship |
| title_sort | associations between retinol binding protein 4 and cardiometabolic profile intertwined intricate relationship |
| topic | cardiometabolic disorders fibrate drugs insulin sensitivity retinol binding protein-4 statins |
| url | http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2020;volume=4;issue=2;spage=95;epage=107;aulast=Naji |
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