Deciphering genetic causality between inflammatory bowel disease and periodontitis through bi-directional two-sample Mendelian randomization
Abstract Inflammatory bowel disease (IBD) and periodontitis are reported to be closely associated; however, whether there is a causal association between them remains unclear. To explore the existence of this causality, this study applied a bidirectional two-sample Mendelian randomization (MR). The...
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Nature Portfolio
2023-10-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-023-45527-z |
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author | Feiyan Yu Yang Yang Dongchao Wu Minjing Chang Chong Han Qianqian Wang Yi Li Dongning He |
author_facet | Feiyan Yu Yang Yang Dongchao Wu Minjing Chang Chong Han Qianqian Wang Yi Li Dongning He |
author_sort | Feiyan Yu |
collection | DOAJ |
description | Abstract Inflammatory bowel disease (IBD) and periodontitis are reported to be closely associated; however, whether there is a causal association between them remains unclear. To explore the existence of this causality, this study applied a bidirectional two-sample Mendelian randomization (MR). The genetic variants were obtained from the summary statistics of genome-wide association studies of IBD, including its subtypes CD and UC, and periodontitis. 175, 148, 113, and six single-nucleotide polymorphisms were selected as instrumental variables for IBD, CD, UC, and periodontitis, respectively. In MR analysis, random-effects inverse-variance weighted was used as the primary method, and weighted median and MR Egger regression were applied as the complementary method. A series of sensitivity analyses were also conducted to ensure the reliability of the results. None of these analyses found a significant effect of genetically proxied IBD and its subtypes on periodontitis, and vice versa. Subsequent sensitivity analyses did not detect any horizontal pleiotropy and heterogeneity. Caution should be exerted when it comes to clinical relevance and further studies are needed to clarify the relationship between IBD and periodontitis. |
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issn | 2045-2322 |
language | English |
last_indexed | 2024-03-11T12:42:00Z |
publishDate | 2023-10-01 |
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spelling | doaj.art-ab7eb0c0aef34c008d1748ff114be58d2023-11-05T12:16:26ZengNature PortfolioScientific Reports2045-23222023-10-0113111010.1038/s41598-023-45527-zDeciphering genetic causality between inflammatory bowel disease and periodontitis through bi-directional two-sample Mendelian randomizationFeiyan Yu0Yang Yang1Dongchao Wu2Minjing Chang3Chong Han4Qianqian Wang5Yi Li6Dongning He7Shanxi Medical University School and Hospital of StomatologyShanxi Medical University School and Hospital of StomatologyShanxi Medical University School and Hospital of StomatologyShanxi Key Laboratory of Big Data for Clinical Decision, Shanxi Medical UniversityShanxi Medical University School and Hospital of StomatologyShanxi Medical University School and Hospital of StomatologyShanxi Province Key Laboratory of Oral Diseases Prevention and New MaterialsShanxi Medical University School and Hospital of StomatologyAbstract Inflammatory bowel disease (IBD) and periodontitis are reported to be closely associated; however, whether there is a causal association between them remains unclear. To explore the existence of this causality, this study applied a bidirectional two-sample Mendelian randomization (MR). The genetic variants were obtained from the summary statistics of genome-wide association studies of IBD, including its subtypes CD and UC, and periodontitis. 175, 148, 113, and six single-nucleotide polymorphisms were selected as instrumental variables for IBD, CD, UC, and periodontitis, respectively. In MR analysis, random-effects inverse-variance weighted was used as the primary method, and weighted median and MR Egger regression were applied as the complementary method. A series of sensitivity analyses were also conducted to ensure the reliability of the results. None of these analyses found a significant effect of genetically proxied IBD and its subtypes on periodontitis, and vice versa. Subsequent sensitivity analyses did not detect any horizontal pleiotropy and heterogeneity. Caution should be exerted when it comes to clinical relevance and further studies are needed to clarify the relationship between IBD and periodontitis.https://doi.org/10.1038/s41598-023-45527-z |
spellingShingle | Feiyan Yu Yang Yang Dongchao Wu Minjing Chang Chong Han Qianqian Wang Yi Li Dongning He Deciphering genetic causality between inflammatory bowel disease and periodontitis through bi-directional two-sample Mendelian randomization Scientific Reports |
title | Deciphering genetic causality between inflammatory bowel disease and periodontitis through bi-directional two-sample Mendelian randomization |
title_full | Deciphering genetic causality between inflammatory bowel disease and periodontitis through bi-directional two-sample Mendelian randomization |
title_fullStr | Deciphering genetic causality between inflammatory bowel disease and periodontitis through bi-directional two-sample Mendelian randomization |
title_full_unstemmed | Deciphering genetic causality between inflammatory bowel disease and periodontitis through bi-directional two-sample Mendelian randomization |
title_short | Deciphering genetic causality between inflammatory bowel disease and periodontitis through bi-directional two-sample Mendelian randomization |
title_sort | deciphering genetic causality between inflammatory bowel disease and periodontitis through bi directional two sample mendelian randomization |
url | https://doi.org/10.1038/s41598-023-45527-z |
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