Saikosaponin A attenuates neural injury caused by ischemia/reperfusion
Inflammation is involved in cerebral ischemia/reperfusion (I/R)-induced neurological damage. Saikosaponin A (SSa), extracted from Radix bupleuri, has been reported to exert anti-inflammatory effects. This article aimed to investigate whether SSa could ameliorate neuroinflammation mediated by ischemi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2020-07-01
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| Series: | Translational Neuroscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/tnsci-2020-0129 |
| _version_ | 1811213365835464704 |
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| author | Wang Xinying Yang Guofeng |
| author_facet | Wang Xinying Yang Guofeng |
| author_sort | Wang Xinying |
| collection | DOAJ |
| description | Inflammation is involved in cerebral ischemia/reperfusion (I/R)-induced neurological damage. Saikosaponin A (SSa), extracted from Radix bupleuri, has been reported to exert anti-inflammatory effects. This article aimed to investigate whether SSa could ameliorate neuroinflammation mediated by ischemic stroke and the underlying mechanism. |
| first_indexed | 2024-04-12T05:45:37Z |
| format | Article |
| id | doaj.art-ab7f058250154e478988370bf0ec2a92 |
| institution | Directory Open Access Journal |
| issn | 2081-6936 |
| language | English |
| last_indexed | 2024-04-12T05:45:37Z |
| publishDate | 2020-07-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Translational Neuroscience |
| spelling | doaj.art-ab7f058250154e478988370bf0ec2a922022-12-22T03:45:28ZengDe GruyterTranslational Neuroscience2081-69362020-07-0111122723510.1515/tnsci-2020-0129tnsci-2020-0129Saikosaponin A attenuates neural injury caused by ischemia/reperfusionWang Xinying0Yang Guofeng1Department of Neurology, Hebei Medical University, No. 361, East Zhongshan Road, Shijiazhuang 050017, Hebei, China; Department of Neurology, Harrison International Peace Hospital, No.180, East Renmin Road, Hengshui 053000, Hebei, ChinaDepartment of Geriatrics, Second Hospital of Hebei Medical University, No. 215, West Heping Road, Shijiazhuang 050000, Hebei, ChinaInflammation is involved in cerebral ischemia/reperfusion (I/R)-induced neurological damage. Saikosaponin A (SSa), extracted from Radix bupleuri, has been reported to exert anti-inflammatory effects. This article aimed to investigate whether SSa could ameliorate neuroinflammation mediated by ischemic stroke and the underlying mechanism.https://doi.org/10.1515/tnsci-2020-0129ischemianeuroprotectionstroketoll-like receptorshmgb1 |
| spellingShingle | Wang Xinying Yang Guofeng Saikosaponin A attenuates neural injury caused by ischemia/reperfusion Translational Neuroscience ischemia neuroprotection stroke toll-like receptors hmgb1 |
| title | Saikosaponin A attenuates neural injury caused by ischemia/reperfusion |
| title_full | Saikosaponin A attenuates neural injury caused by ischemia/reperfusion |
| title_fullStr | Saikosaponin A attenuates neural injury caused by ischemia/reperfusion |
| title_full_unstemmed | Saikosaponin A attenuates neural injury caused by ischemia/reperfusion |
| title_short | Saikosaponin A attenuates neural injury caused by ischemia/reperfusion |
| title_sort | saikosaponin a attenuates neural injury caused by ischemia reperfusion |
| topic | ischemia neuroprotection stroke toll-like receptors hmgb1 |
| url | https://doi.org/10.1515/tnsci-2020-0129 |
| work_keys_str_mv | AT wangxinying saikosaponinaattenuatesneuralinjurycausedbyischemiareperfusion AT yangguofeng saikosaponinaattenuatesneuralinjurycausedbyischemiareperfusion |