Lentivirus-mediated Persephin over-expression in Parkinson′s disease rats
Persephin, together with glial cell line-derived neurotrophic factor and neurturin, has a neurotrophic effect and promotes the survival of motor neurons cultured in vitro. In this study, dopaminergic neurons in the substantia nigra of rats were transfected with the Persephin gene. One week later 6-h...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=11;spage=1814;epage=1818;aulast=Yin |
| _version_ | 1818881061887672320 |
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| author | Xiao-feng Yin Hua-min Xu Yun-xia Jiang Yun-lai Zhi Yu-xiu Liu Heng-wei Xiang Kai Liu Xiao-dong Ding Peng Sun |
| author_facet | Xiao-feng Yin Hua-min Xu Yun-xia Jiang Yun-lai Zhi Yu-xiu Liu Heng-wei Xiang Kai Liu Xiao-dong Ding Peng Sun |
| author_sort | Xiao-feng Yin |
| collection | DOAJ |
| description | Persephin, together with glial cell line-derived neurotrophic factor and neurturin, has a neurotrophic effect and promotes the survival of motor neurons cultured in vitro. In this study, dopaminergic neurons in the substantia nigra of rats were transfected with the Persephin gene. One week later 6-hydroxydopamine was injected into the anterior medial bundle to establish a Parkinson′s disease model in the rats. Results found that the number of dopaminergic neurons in the substantia nigra increased, tyrosine hydroxylase expression was upregulated and concentrations of dopamine and its metabolites in corpus striatum were increased after pretreatment with Persephin gene. In addition, the rotating effect of the induced Parkinson′s disease rats was much less in the group pretreated with the Persephin gene. Persephin has a neuroprotective effect on the 6-hydroxydopamine-induced Parkinson′s disease through protecting dopaminergic neurons. |
| first_indexed | 2024-12-19T14:55:53Z |
| format | Article |
| id | doaj.art-ab7f60766ee84e139cbe319c7d6ec607 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-19T14:55:53Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-ab7f60766ee84e139cbe319c7d6ec6072022-12-21T20:16:43ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742015-01-0110111814181810.4103/1673-5374.170309Lentivirus-mediated Persephin over-expression in Parkinson′s disease ratsXiao-feng YinHua-min XuYun-xia JiangYun-lai ZhiYu-xiu LiuHeng-wei XiangKai LiuXiao-dong DingPeng SunPersephin, together with glial cell line-derived neurotrophic factor and neurturin, has a neurotrophic effect and promotes the survival of motor neurons cultured in vitro. In this study, dopaminergic neurons in the substantia nigra of rats were transfected with the Persephin gene. One week later 6-hydroxydopamine was injected into the anterior medial bundle to establish a Parkinson′s disease model in the rats. Results found that the number of dopaminergic neurons in the substantia nigra increased, tyrosine hydroxylase expression was upregulated and concentrations of dopamine and its metabolites in corpus striatum were increased after pretreatment with Persephin gene. In addition, the rotating effect of the induced Parkinson′s disease rats was much less in the group pretreated with the Persephin gene. Persephin has a neuroprotective effect on the 6-hydroxydopamine-induced Parkinson′s disease through protecting dopaminergic neurons.http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=11;spage=1814;epage=1818;aulast=Yinnerve regeneration; Persephin; lentivirus; Parkinson′s disease; dopaminergic neurons; gene therapy; over-expression; transfection; striatum; neural regeneration |
| spellingShingle | Xiao-feng Yin Hua-min Xu Yun-xia Jiang Yun-lai Zhi Yu-xiu Liu Heng-wei Xiang Kai Liu Xiao-dong Ding Peng Sun Lentivirus-mediated Persephin over-expression in Parkinson′s disease rats Neural Regeneration Research nerve regeneration; Persephin; lentivirus; Parkinson′s disease; dopaminergic neurons; gene therapy; over-expression; transfection; striatum; neural regeneration |
| title | Lentivirus-mediated Persephin over-expression in Parkinson′s disease rats |
| title_full | Lentivirus-mediated Persephin over-expression in Parkinson′s disease rats |
| title_fullStr | Lentivirus-mediated Persephin over-expression in Parkinson′s disease rats |
| title_full_unstemmed | Lentivirus-mediated Persephin over-expression in Parkinson′s disease rats |
| title_short | Lentivirus-mediated Persephin over-expression in Parkinson′s disease rats |
| title_sort | lentivirus mediated persephin over expression in parkinson s disease rats |
| topic | nerve regeneration; Persephin; lentivirus; Parkinson′s disease; dopaminergic neurons; gene therapy; over-expression; transfection; striatum; neural regeneration |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=11;spage=1814;epage=1818;aulast=Yin |
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