Hormonal receptors in mammary carcinoma: comparison between quantitative and qualitative methods
Alternatives to the traditional hormone receptor dosages for prognostic evaluation and clinical approach to breast cancer have been proposed for immunohistochemical determinations. For correlation purposes, such procedures were compared in 37 patients presenting 5 to 15 years of survival. Considerin...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Paulista de Medicina
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| Series: | São Paulo Medical Journal |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000400004&lng=en&tlng=en |
| _version_ | 1819171509932916736 |
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| author | Antonio Franco Montoro Osvaldo Giannotti Filho Darcy Marchione Monteiro Flávio Franco Montoro Maria Aparecida Pinho Marco Túlio Assis Figueiredo |
| author_facet | Antonio Franco Montoro Osvaldo Giannotti Filho Darcy Marchione Monteiro Flávio Franco Montoro Maria Aparecida Pinho Marco Túlio Assis Figueiredo |
| author_sort | Antonio Franco Montoro |
| collection | DOAJ |
| description | Alternatives to the traditional hormone receptor dosages for prognostic evaluation and clinical approach to breast cancer have been proposed for immunohistochemical determinations. For correlation purposes, such procedures were compared in 37 patients presenting 5 to 15 years of survival. Considering 30 fm/mg as the positivity index, the disagreement between both methods reached 35.1% with estrogen and 48.5% with progesterone receptors. When the positiveness level was changed to 20 fm/mg, the discrepancies were reduced to 32% with ER and increased to 57% with PgR. This study leads us to not recommend the immunohistochemical method applied to paraffin sections as an alternative procedure to the dextran-charcoal dosage for prognosis and therapeutic management of mammary carcinoma. |
| first_indexed | 2024-12-22T19:52:26Z |
| format | Article |
| id | doaj.art-ab7f73e3a1d3422c87a702530fc169b8 |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-12-22T19:52:26Z |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-ab7f73e3a1d3422c87a702530fc169b82022-12-21T18:14:31ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-946011541471147410.1590/S1516-31801997000400004S1516-31801997000400004Hormonal receptors in mammary carcinoma: comparison between quantitative and qualitative methodsAntonio Franco Montoro0Osvaldo Giannotti Filho1Darcy Marchione Monteiro2Flávio Franco Montoro3Maria Aparecida Pinho4Marco Túlio Assis Figueiredo5Fundação Oncocentro de São PauloFundação Oncocentro de São PauloFundação Oncocentro de São PauloFundação Oncocentro de São PauloFundação Oncocentro de São PauloFundação Oncocentro de São PauloAlternatives to the traditional hormone receptor dosages for prognostic evaluation and clinical approach to breast cancer have been proposed for immunohistochemical determinations. For correlation purposes, such procedures were compared in 37 patients presenting 5 to 15 years of survival. Considering 30 fm/mg as the positivity index, the disagreement between both methods reached 35.1% with estrogen and 48.5% with progesterone receptors. When the positiveness level was changed to 20 fm/mg, the discrepancies were reduced to 32% with ER and increased to 57% with PgR. This study leads us to not recommend the immunohistochemical method applied to paraffin sections as an alternative procedure to the dextran-charcoal dosage for prognosis and therapeutic management of mammary carcinoma.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000400004&lng=en&tlng=enBreast carcinomaPrognosisHormonal receptors assaysCorrelation of methods |
| spellingShingle | Antonio Franco Montoro Osvaldo Giannotti Filho Darcy Marchione Monteiro Flávio Franco Montoro Maria Aparecida Pinho Marco Túlio Assis Figueiredo Hormonal receptors in mammary carcinoma: comparison between quantitative and qualitative methods São Paulo Medical Journal Breast carcinoma Prognosis Hormonal receptors assays Correlation of methods |
| title | Hormonal receptors in mammary carcinoma: comparison between quantitative and qualitative methods |
| title_full | Hormonal receptors in mammary carcinoma: comparison between quantitative and qualitative methods |
| title_fullStr | Hormonal receptors in mammary carcinoma: comparison between quantitative and qualitative methods |
| title_full_unstemmed | Hormonal receptors in mammary carcinoma: comparison between quantitative and qualitative methods |
| title_short | Hormonal receptors in mammary carcinoma: comparison between quantitative and qualitative methods |
| title_sort | hormonal receptors in mammary carcinoma comparison between quantitative and qualitative methods |
| topic | Breast carcinoma Prognosis Hormonal receptors assays Correlation of methods |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000400004&lng=en&tlng=en |
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